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Q5L748 (PGK_CHLAB) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase

EC=2.7.2.3
Gene names
Name:pgk
Ordered Locus Names:CAB062
OrganismChlamydophila abortus (strain DSM 27085 / S26/3) [Complete proteome] [HAMAP]
Taxonomic identifier218497 [NCBI]
Taxonomic lineageBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydophila

Protein attributes

Sequence length403 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00145

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 403403Phosphoglycerate kinase HAMAP-Rule MF_00145
PRO_1000057974

Regions

Nucleotide binding357 – 3604ATP By similarity
Region21 – 233Substrate binding By similarity
Region59 – 624Substrate binding By similarity

Sites

Binding site361Substrate By similarity
Binding site1191Substrate By similarity
Binding site1541Substrate By similarity
Binding site2071ATP By similarity
Binding site2991ATP; via carbonyl oxygen By similarity
Binding site3301ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5L748 [UniParc].

Last modified June 21, 2005. Version 1.
Checksum: 6A347CE51492CD49

FASTA40343,302
        10         20         30         40         50         60 
MDRLTVRELS PEEKKVLVRV DFNVPIKDGK ILDDIRIRSA MPTIHYLLQK RAAVILMSHL 

        70         80         90        100        110        120 
GRPQGKGFEE KYSLQPVVEV LEGYLGHHVP LAPDCVGEVA RQAVAQISPG RVLLLENLRF 

       130        140        150        160        170        180 
HPGEEHPEEH PAFAAELSSY GDFYVNDAFG TSHRKHASVY TVPQAFPGRS AAGLLMEKEL 

       190        200        210        220        230        240 
EFLGQHLLIS PKRPFTAILG GSKVSSKIGV IEALLSQVDN LLLAGGMGFT FLKALGKSVG 

       250        260        270        280        290        300 
NSLVEESGIE LARRVLHIAQ QRNVRIVLPI DVKVAKACTP AVSWTEVSID QGIPQDLEGL 

       310        320        330        340        350        360 
DIGTKTVQEF CKIIDASSTI FWNGPVGVYE VPPFDQGSMA IANCLARHPS AITVVGGGDA 

       370        380        390        400 
AAVVALAGCT AQVSHVSTGG GASLEFLEKG FLPGTEVLSP SQE 

« Hide

References

[1]"The Chlamydophila abortus genome sequence reveals an array of variable proteins that contribute to interspecies variation."
Thomson N.R., Yeats C., Bell K., Holden M.T.G., Bentley S.D., Livingstone M., Cerdeno-Tarraga A.-M., Harris B., Doggett J., Ormond D., Mungall K., Clarke K., Feltwell T., Hance Z., Sanders M., Quail M.A., Price C., Barrell B.G., Parkhill J., Longbottom D.
Genome Res. 15:629-640(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 27085 / S26/3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR848038 Genomic DNA. Translation: CAH63520.1.
RefSeqYP_219494.1. NC_004552.2.

3D structure databases

ProteinModelPortalQ5L748.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING218497.CAB062.

Proteomic databases

PRIDEQ5L748.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAH63520; CAH63520; CAB062.
GeneID3337662.
KEGGcab:CAB062.
PATRIC20201478. VBIChlAbo21869_0066.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0126.
HOGENOMHOG000227107.
KOK00927.
OMAFNVPLRE.
OrthoDBEOG64N9Z0.

Enzyme and pathway databases

BioCycCABO218497:GJB0-68-MONOMER.
UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGK_CHLAB
AccessionPrimary (citable) accession number: Q5L748
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 21, 2005
Last modified: June 11, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways