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Q5L6X6 (HEMH_CHLAB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:CAB136
OrganismChlamydophila abortus [Complete proteome] [HAMAP]
Taxonomic identifier83555 [NCBI]
Taxonomic lineageBacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydophila

Protein attributes

Sequence length318 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 318318Ferrochelatase HAMAP MF_00323
PRO_1000019290

Sites

Metal binding1861Iron By similarity
Metal binding2641Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5L6X6 [UniParc].

Last modified June 21, 2005. Version 1.
Checksum: F927C34530B6DD50

FASTA31836,154
        10         20         30         40         50         60 
MVSTYLLANF GGPRHSHDVE VFLTSLLTDR DVTGGCLPSF LHKRLFSFIA KKRAPKVVPQ 

        70         80         90        100        110        120 
YNCIGGYSPI YQDTEALAKT LSSHLDAPVI TFHRYLPDTH SQTIQQLKTL GDLPVVGVPL 

       130        140        150        160        170        180 
FPHFTYAVTG SIVRFIHNHL PSLNISWVAH FGNHPQFISC MIDHILEFLQ SHDIPTHDCC 

       190        200        210        220        230        240 
LLFSAHGLPM RYVNKGDPYN VQCEKSFAAI SERLPNIETF LCYQSKFGLG KWLTPSTKEV 

       250        260        270        280        290        300 
CKTLKTNKKY VLIVPFGFTS DHIETLYEIE KEYIAILIDR KYQALRVPAI YQSPQWVQSL 

       310 
ATIIQSTRYV EKHSLIKS

« Hide

References

[1]"The Chlamydophila abortus genome sequence reveals an array of variable proteins that contribute to interspecies variation."
Thomson N.R., Yeats C., Bell K., Holden M.T.G., Bentley S.D., Livingstone M., Cerdeno-Tarraga A.-M., Harris B., Doggett J., Ormond D., Mungall K., Clarke K., Feltwell T., Hance Z., Sanders M., Quail M.A., Price C., Barrell B.G., Parkhill J., Longbottom D.
Genome Res. 15:629-640(2005) [PubMed: 15837807] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: S26/3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR848038 Genomic DNA. Translation: CAH63594.1.
RefSeqYP_219566.1. NC_004552.2.

3D structure databases

HSSPHSSP built from PDB template 1HRK based on UniProtKB P22830.
ProteinModelPortalQ5L6X6.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3337994.
GenomeReviewsGene locus CAB136 in contig CR848038_GR.
KEGGcab:CAB136.
PATRIC20201644. VBIChlAbo21869_0146.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG697135.
OMALLQMGGP.
PhylomeDBQ5L6X6.
ProtClustDBPRK00035.

Enzyme and pathway databases

BioCycCABO218497:CAB136-MONOMER.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_CHLAB
AccessionPrimary (citable) accession number: Q5L6X6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 21, 2005
Last modified: January 25, 2012
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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