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Q5L6U4 (SYR_CHLAB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:CAB169
OrganismChlamydophila abortus (strain DSM 27085 / S26/3) [Complete proteome] [HAMAP]
Taxonomic identifier218497 [NCBI]
Taxonomic lineageBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydophila

Protein attributes

Sequence length562 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 562562Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_0000242005

Regions

Motif122 – 13211"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
Q5L6U4 [UniParc].

Last modified June 21, 2005. Version 1.
Checksum: 5C341D3EE7C532F4

FASTA56263,786
        10         20         30         40         50         60 
MTLLSYLSSL CREAILSAFP QIETISPDIT QSTKELFGHY QCNDAMKLAR TLKMPPRAIA 

        70         80         90        100        110        120 
ESIVKQISKN NFSSIEIAGA GFINFTFSKE FLNLSLQSYS RDLSSGFRVQ DPKKVVIDFS 

       130        140        150        160        170        180 
SPNIAKDMHV GHLRSTIIGD CLARIFTFVG HDVLRLNHIG DWGTAFGMLI TYLQEESSED 

       190        200        210        220        230        240 
IESLEDLTIL YKKAHVRFAE DAEFKKRSQT NVVALQSGDP KARKLWERIC EISERAFQKI 

       250        260        270        280        290        300 
YNILDIQIEK RGESFYNPFL PEIIEDLEKK NLITVSDEAK CVFHEGFSIP LMVQKRDGGY 

       310        320        330        340        350        360 
NYATTDLAAM RYRVEQDHAD RIIIVTDMGQ SLHFQLLEAT ALAAGYLPNK DVFSHVGFGL 

       370        380        390        400        410        420 
VLDSEGKKFK TRSGENIKLQ ELLDTAIDQA VATLKKHRPE MSDAEITERA PVLGMNAIKY 

       430        440        450        460        470        480 
ADLSSHRVSD YVFSFEKMLR FEGNTAMFIL YGYVRIQGIK RRLGIEKLSL ESAANIQEPS 

       490        500        510        520        530        540 
EEALALALLR FPEAIDITLK ELCPHFLTDY LYMLTNKFHA FFRDCHIEGS PHQKERLYLC 

       550        560 
ALVEKTLATG MHLLGLQTLD RL 

« Hide

References

[1]"The Chlamydophila abortus genome sequence reveals an array of variable proteins that contribute to interspecies variation."
Thomson N.R., Yeats C., Bell K., Holden M.T.G., Bentley S.D., Livingstone M., Cerdeno-Tarraga A.-M., Harris B., Doggett J., Ormond D., Mungall K., Clarke K., Feltwell T., Hance Z., Sanders M., Quail M.A., Price C., Barrell B.G., Parkhill J., Longbottom D.
Genome Res. 15:629-640(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 27085 / S26/3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR848038 Genomic DNA. Translation: CAH63627.1.
RefSeqYP_219598.1. NC_004552.2.

3D structure databases

ProteinModelPortalQ5L6U4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING218497.CAB169.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAH63627; CAH63627; CAB169.
GeneID3337258.
KEGGcab:CAB169.
PATRIC20201728. VBIChlAbo21869_0185.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0018.
HOGENOMHOG000247212.
KOK01887.
OMAPDIAYHI.
OrthoDBEOG6JB13C.

Enzyme and pathway databases

BioCycCABO218497:GJB0-182-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_CHLAB
AccessionPrimary (citable) accession number: Q5L6U4
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 21, 2005
Last modified: May 14, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries