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Q5L6U0 (ISPT_CHLAB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Isoprenyl transferase
EC=2.5.1.-
Gene names
Name:uppS
Ordered Locus Names:CAB173
OrganismChlamydophila abortus (strain S26/3) [Complete proteome] [HAMAP]
Taxonomic identifier218497 [NCBI]
Taxonomic lineageBacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydophila ›

Protein attributes

Sequence length250 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids By similarity. HAMAP-Rule MF_01139

Cofactor

Binds 2 magnesium ions per subunit By similarity. HAMAP-Rule MF_01139

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01139

Sequence similarities

Belongs to the UPP synthase family.

Ontologies

Keywords
   LigandMagnesium
Metal-binding
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functionmagnesium ion binding

Inferred from electronic annotation. Source: HAMAP

prenyltransferase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 250250Isoprenyl transferase HAMAP-Rule MF_01139
PRO_0000123591

Regions

Region28 – 314Substrate binding By similarity
Region76 – 783Substrate binding By similarity
Region205 – 2073Substrate binding By similarity

Sites

Active site271 By similarity
Active site791Proton acceptor By similarity
Metal binding271Magnesium By similarity
Metal binding2181Magnesium By similarity
Binding site321Substrate By similarity
Binding site481Substrate By similarity
Binding site801Substrate By similarity
Binding site821Substrate By similarity
Binding site1991Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5L6U0 [UniParc].

Last modified June 21, 2005. Version 1.
Checksum: AF8344863A2E77AE

FASTA25028,611
        10         20         30         40         50         60 
MSLTLKQADQ ASLSMQSLPK HVAIIMDGNR RWYRQHQAQC SIKSSSGHYY GAKVLPNIIE 

        70         80         90        100        110        120 
SAFSLGIEVL TLFAFSTENF LRSAEEVAEL FSLFHAQLDE QLPYLIENKI RLRCIGNLLA 

       130        140        150        160        170        180 
LPPDLQQQIA KVASETQRHG MRELVLAINY GGKDELVRAF KKLHHDLVNK KISLDSVSEE 

       190        200        210        220        230        240 
LIRLYLDTSE IPDPDLLIRT GGEMRVSNFL LWQIAYTELY VTDVLWPDFK PYHLLDAIKA 

       250 
YQHRSRRGGK

« Hide

References

[1]"The Chlamydophila abortus genome sequence reveals an array of variable proteins that contribute to interspecies variation."
Thomson N.R., Yeats C., Bell K., Holden M.T.G., Bentley S.D., Livingstone M., Cerdeno-Tarraga A.-M., Harris B., Doggett J., Ormond D., Mungall K., Clarke K., Feltwell T., Hance Z., Sanders M., Quail M.A., Price C., Barrell B.G., Parkhill J., Longbottom D.
Genome Res. 15:629-640(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: S26/3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR848038 Genomic DNA. Translation: CAH63631.1.
RefSeqYP_219602.1. NC_004552.2.

3D structure databases

ProteinModelPortalQ5L6U0.
ModBaseSearch...

Protein-protein interaction databases

STRING218497.CAB173.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAH63631; CAH63631; CAB173.
GeneID3337531.
KEGGcab:CAB173.
PATRIC20201736. VBIChlAbo21869_0189.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0020.
HOGENOMHOG000006054.
KOK00806.
OMAFLWRIAY.
ProtClustDBPRK14840.

Enzyme and pathway databases

BioCycCABO218497:GJB0-186-MONOMER.

Family and domain databases

Gene3D3.40.1180.10. 1 hit.
HAMAPMF_01139. ISPT.
InterProIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERPTHR10291. PTHR10291. 1 hit.
PfamPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMSSF64005. UPP_synth. 1 hit.
TIGRFAMsTIGR00055. uppS. 1 hit.
PROSITEPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameISPT_CHLAB
AccessionPrimary (citable) accession number: Q5L6U0
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: June 21, 2005
Last modified: May 1, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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