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Q5L6R4

- THIM_CHLAB

UniProt

Q5L6R4 - THIM_CHLAB

Protein

Hydroxyethylthiazole kinase

Gene

thiM

Organism
Chlamydophila abortus (strain DSM 27085 / S26/3)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (21 Jun 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).UniRule annotation

    Catalytic activityi

    ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei44 – 441Substrate; via amide nitrogenUniRule annotation
    Binding sitei118 – 1181ATPUniRule annotation
    Binding sitei166 – 1661ATPUniRule annotation
    Binding sitei193 – 1931Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. thiamine biosynthetic process Source: UniProtKB-KW
    2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Thiamine biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCABO218497:GJB0-214-MONOMER.
    UniPathwayiUPA00060; UER00139.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hydroxyethylthiazole kinaseUniRule annotation (EC:2.7.1.50UniRule annotation)
    Alternative name(s):
    4-methyl-5-beta-hydroxyethylthiazole kinaseUniRule annotation
    Short name:
    TH kinaseUniRule annotation
    Short name:
    Thz kinaseUniRule annotation
    Gene namesi
    Name:thiMUniRule annotation
    Ordered Locus Names:CAB199
    OrganismiChlamydophila abortus (strain DSM 27085 / S26/3)
    Taxonomic identifieri218497 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydophila
    ProteomesiUP000001012: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 262262Hydroxyethylthiazole kinasePRO_0000383832Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi218497.CAB199.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5L6R4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Thz kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2145.
    HOGENOMiHOG000114352.
    KOiK00878.
    OMAiIMALANM.
    OrthoDBiEOG628F8M.

    Family and domain databases

    Gene3Di3.40.1190.20. 1 hit.
    HAMAPiMF_00228. Thz_kinase.
    InterProiIPR000417. Hyethyz_kinase.
    IPR029056. Ribokinase-like.
    [Graphical view]
    PfamiPF02110. HK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000513. Thz_kinase. 1 hit.
    PRINTSiPR01099. HYETHTZKNASE.
    SUPFAMiSSF53613. SSF53613. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5L6R4-1 [UniParc]FASTAAdd to Basket

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    MLERMQEALQ RLRKERPVIL NTTNYVSMDF LANCFLAIGA SPIMSVSDLE    50
    LEELIELSSA VYINIGTLDH LFIQRAYRTV DLAVRQNKPV IFDPVAAGAT 100
    KIRTEVSHHL LAHATIVRGN ASEILSFGDV TMKTRGVDST HSTQDAKDVA 150
    TALAKECLCG CAIAVSGAID FITDGQRHTT VELGDPFMSY VVGMGCSLTG 200
    VFAAFRSVID DSFEATKLGI EYFTLCGMLA RERCEGPGLF KAYLLDELYA 250
    SDFSRMRQYY DR 262
    Length:262
    Mass (Da):28,947
    Last modified:June 21, 2005 - v1
    Checksum:i26089FE016BCF85E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR848038 Genomic DNA. Translation: CAH63657.1.
    RefSeqiWP_011096893.1. NC_004552.2.
    YP_219628.1. NC_004552.2.

    Genome annotation databases

    EnsemblBacteriaiCAH63657; CAH63657; CAB199.
    GeneIDi3338216.
    KEGGicab:CAB199.
    PATRICi20201806. VBIChlAbo21869_0222.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR848038 Genomic DNA. Translation: CAH63657.1 .
    RefSeqi WP_011096893.1. NC_004552.2.
    YP_219628.1. NC_004552.2.

    3D structure databases

    ProteinModelPortali Q5L6R4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 218497.CAB199.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAH63657 ; CAH63657 ; CAB199 .
    GeneIDi 3338216.
    KEGGi cab:CAB199.
    PATRICi 20201806. VBIChlAbo21869_0222.

    Phylogenomic databases

    eggNOGi COG2145.
    HOGENOMi HOG000114352.
    KOi K00878.
    OMAi IMALANM.
    OrthoDBi EOG628F8M.

    Enzyme and pathway databases

    UniPathwayi UPA00060 ; UER00139 .
    BioCyci CABO218497:GJB0-214-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1190.20. 1 hit.
    HAMAPi MF_00228. Thz_kinase.
    InterProi IPR000417. Hyethyz_kinase.
    IPR029056. Ribokinase-like.
    [Graphical view ]
    Pfami PF02110. HK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000513. Thz_kinase. 1 hit.
    PRINTSi PR01099. HYETHTZKNASE.
    SUPFAMi SSF53613. SSF53613. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 27085 / S26/3.

    Entry informationi

    Entry nameiTHIM_CHLAB
    AccessioniPrimary (citable) accession number: Q5L6R4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: June 21, 2005
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3