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Q5L6R4

- THIM_CHLAB

UniProt

Q5L6R4 - THIM_CHLAB

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Protein

Hydroxyethylthiazole kinase

Gene

thiM

Organism
Chlamydophila abortus (strain DSM 27085 / S26/3)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).UniRule annotation

Catalytic activityi

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

Cofactori

Magnesium.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei44 – 441Substrate; via amide nitrogenUniRule annotation
Binding sitei118 – 1181ATPUniRule annotation
Binding sitei166 – 1661ATPUniRule annotation
Binding sitei193 – 1931Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. thiamine biosynthetic process Source: UniProtKB-KW
  2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Thiamine biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCABO218497:GJB0-214-MONOMER.
UniPathwayiUPA00060; UER00139.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyethylthiazole kinaseUniRule annotation (EC:2.7.1.50UniRule annotation)
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinaseUniRule annotation
Short name:
TH kinaseUniRule annotation
Short name:
Thz kinaseUniRule annotation
Gene namesi
Name:thiMUniRule annotation
Ordered Locus Names:CAB199
OrganismiChlamydophila abortus (strain DSM 27085 / S26/3)
Taxonomic identifieri218497 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydophila
ProteomesiUP000001012: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 262262Hydroxyethylthiazole kinasePRO_0000383832Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi218497.CAB199.

Structurei

3D structure databases

ProteinModelPortaliQ5L6R4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Thz kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2145.
HOGENOMiHOG000114352.
KOiK00878.
OMAiIMALANM.
OrthoDBiEOG628F8M.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
HAMAPiMF_00228. Thz_kinase.
InterProiIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF02110. HK. 1 hit.
[Graphical view]
PIRSFiPIRSF000513. Thz_kinase. 1 hit.
PRINTSiPR01099. HYETHTZKNASE.
SUPFAMiSSF53613. SSF53613. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5L6R4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLERMQEALQ RLRKERPVIL NTTNYVSMDF LANCFLAIGA SPIMSVSDLE
60 70 80 90 100
LEELIELSSA VYINIGTLDH LFIQRAYRTV DLAVRQNKPV IFDPVAAGAT
110 120 130 140 150
KIRTEVSHHL LAHATIVRGN ASEILSFGDV TMKTRGVDST HSTQDAKDVA
160 170 180 190 200
TALAKECLCG CAIAVSGAID FITDGQRHTT VELGDPFMSY VVGMGCSLTG
210 220 230 240 250
VFAAFRSVID DSFEATKLGI EYFTLCGMLA RERCEGPGLF KAYLLDELYA
260
SDFSRMRQYY DR
Length:262
Mass (Da):28,947
Last modified:June 21, 2005 - v1
Checksum:i26089FE016BCF85E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR848038 Genomic DNA. Translation: CAH63657.1.
RefSeqiYP_219628.1. NC_004552.2.

Genome annotation databases

EnsemblBacteriaiCAH63657; CAH63657; CAB199.
GeneIDi3338216.
KEGGicab:CAB199.
PATRICi20201806. VBIChlAbo21869_0222.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR848038 Genomic DNA. Translation: CAH63657.1 .
RefSeqi YP_219628.1. NC_004552.2.

3D structure databases

ProteinModelPortali Q5L6R4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 218497.CAB199.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAH63657 ; CAH63657 ; CAB199 .
GeneIDi 3338216.
KEGGi cab:CAB199.
PATRICi 20201806. VBIChlAbo21869_0222.

Phylogenomic databases

eggNOGi COG2145.
HOGENOMi HOG000114352.
KOi K00878.
OMAi IMALANM.
OrthoDBi EOG628F8M.

Enzyme and pathway databases

UniPathwayi UPA00060 ; UER00139 .
BioCyci CABO218497:GJB0-214-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.20. 1 hit.
HAMAPi MF_00228. Thz_kinase.
InterProi IPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view ]
Pfami PF02110. HK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000513. Thz_kinase. 1 hit.
PRINTSi PR01099. HYETHTZKNASE.
SUPFAMi SSF53613. SSF53613. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 27085 / S26/3.

Entry informationi

Entry nameiTHIM_CHLAB
AccessioniPrimary (citable) accession number: Q5L6R4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 21, 2005
Last modified: October 29, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3