Q5L6H4 (DXS_CHLAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
1-deoxy-D-xylulose-5-phosphate synthase
EC=2.2.1.7

Alternative name(s):
1-deoxyxylulose-5-phosphate synthase
Short name=DXP synthase
Short name=DXPS

Gene names

Name:	dxs
Ordered Locus Names:	CAB301

Organism

Chlamydophila abortus [Complete proteome] [HAMAP]

Taxonomic identifier

83555 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydophila

Protein attributes

Sequence length	644 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity. HAMAP MF_00315
Catalytic activity	Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315
Cofactor	Binds 1 thiamine pyrophosphate per subunit By similarity.
Pathway	Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315
Subunit structure	Homodimer By similarity. HAMAP MF_00315
Sequence similarities	Belongs to the transketolase family. DXPS subfamily.

Ontologies

Keywords
Biological process	Isoprene biosynthesis Thiamine biosynthesis
Ligand	Thiamine pyrophosphate
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	terpenoid biosynthetic process Inferred from electronic annotation. Source: InterPro thiamine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	1-deoxy-D-xylulose-5-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 644	644	1-deoxy-D-xylulose-5-phosphate synthase HAMAP MF_00315		PRO_0000256396

Sequences

	Sequence		Length	Mass (Da)
	Q5L6H4 [UniParc]. Last modified June 21, 2005. Version 1. Checksum: 8E38856ED33521C8	FASTA	644	71,160
	10 20 30 40 50 60 MTSYTSSILS QISSPEDLKK LSCSELSLLA EQIRHKIISV LIKTGGHLAS NLGIIELTIA 70 80 90 100 110 120 LHYVFSSPED KFIFDVGHQT YTHKLLTGRN IEEFERIRHD GGLSGFTSPL ESAHDLFFSG 130 140 150 160 170 180 HAGNALSLAL GMAKATEKSR THVLPILGDA AFSCGLTFEA LNNIHTDLSK FIVILNDNNM 190 200 210 220 230 240 SISKNVGVMS KSLSQWIHHP KFSLLSRKLE RSLSKIPRYG KSIAKCSHKI STCLRSLVCP 250 260 270 280 290 300 IPIFEQFNLA YMGPVDGHDI KALVSLFQKV RDLPFPILIH VCTKKGKGLE IAQENPTKYH 310 320 330 340 350 360 GVKANFKLTA EDKLLPTIQP QLTYPDIFGK TVCKLGEISP NLHVVTPAMS LGSRLETFKG 370 380 390 400 410 420 TFPERFIDVG IAEGHAVTFS AGIAKANTPV ICSIYSTFLH RAMDNVFHDV CLQNLPVIFG 430 440 450 460 470 480 IDRAGLAYGD GCSHHGIYDL SFLRAMPNMI ICQPRSSIVF QQLLQSSLHW QRPSAIRYPN 490 500 510 520 530 540 IPALQGDPIA TDINLYRDPG LGEILSQGED VLIVGLGHMC SAALSIKLQL LSHGISATVV 550 560 570 580 590 600 DPIFIKPFDN NLFSILLMHH SKVIIIEEHS IRGGLASEFN DFLATYNFKV DVLHFGIPDS 610 620 630 640 IFSHGDKENL LQRVGLDVDS MVKRILTYFN FRTKKAPSNK LSIV

References

[1]

"The Chlamydophila abortus genome sequence reveals an array of variable proteins that contribute to interspecies variation." Thomson N.R., Yeats C., Bell K., Holden M.T.G., Bentley S.D., Livingstone M., Cerdeno-Tarraga A.-M., Harris B., Doggett J., Ormond D., Mungall K., Clarke K., Feltwell T., Hance Z., Sanders M., Quail M.A., Price C., Barrell B.G., Parkhill J., Longbottom D. Genome Res. 15:629-640(2005) [PubMed: 15837807] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: S26/3.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR848038 Genomic DNA. Translation: CAH63751.1.
RefSeq	YP_219718.1. NC_004552.2.
3D structure databases
ProteinModelPortal	Q5L6H4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3337657.
GenomeReviews	Gene locus CAB301 in contig CR848038_GR.
KEGG	cab:CAB301.
PATRIC	20202033. VBIChlAbo21869_0334.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG571647.
OMA	DPILYHG.
ProtClustDB	PRK05444.
Enzyme and pathway databases
BioCyc	CABO218497:CAB301-MONOMER.
Family and domain databases
HAMAP	MF_00315. DXP_synth. [Tree]
InterPro	IPR005477. Dxylulose-5-P_synthase. IPR009014. Transketo_C/Pyr-ferredox_oxred. IPR015941. Transketolase-like_C. IPR005475. Transketolase-like_Pyr-bd. IPR005476. Transketolase_C. IPR005474. Transketolase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KO	K01662.
Pfam	PF02779. Transket_pyr. 1 hit. PF02780. Transketolase_C. 1 hit. [Graphical view]
SMART	SM00861. Transket_pyr. 1 hit. [Graphical view]
SUPFAM	SSF52922. Transketo_C_like. 1 hit.
TIGRFAMs	TIGR00204. Dxs. 1 hit.
PROSITE	PS00801. TRANSKETOLASE_1. 1 hit. PS00802. TRANSKETOLASE_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DXS_CHLAB

Accession

Primary (citable) accession number: Q5L6H4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	June 21, 2005
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program