Q5L612 (LPXD_CHLAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UDP-3-O-acylglucosamine N-acyltransferase
EC=2.3.1.-

Gene names

Name:	lpxD
Ordered Locus Names:	CAB466

Organism

Chlamydophila abortus [Complete proteome] [HAMAP]

Taxonomic identifier

83555 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydophila

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP MF_00523
Catalytic activity	(3R)-3-hydroxyacyl-[acyl-carrier-protein] + UDP-3-O-acyl-alpha-D-glucosamine = UDP-2,3-diacyl-alpha-D-glucosamine + [acyl-carrier-protein]. HAMAP MF_00523
Pathway	Bacterial outer membrane biogenesis; LPS lipid A biosynthesis. HAMAP MF_00523
Subunit structure	Homotrimer By similarity. HAMAP MF_00523
Sequence similarities	Belongs to the transferase hexapeptide repeat family. LpxD subfamily.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid synthesis
Domain	Repeat
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	transferase activity, transferring acyl groups other than amino-acyl groups Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 359	359	UDP-3-O-acylglucosamine N-acyltransferase HAMAP MF_00523		PRO_0000264357
Sites
	Active site	248	1	Proton acceptor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5L612 [UniParc]. Last modified June 21, 2005. Version 1. Checksum: 92A94CDEAEAC9BF7	FASTA	359	38,764
	10 20 30 40 50 60 MPQELVYTLQ QLADLLKVEV QGNTETPISG VEEISAAKAH HVTFLDNEKY ARFIKITEAG 70 80 90 100 110 120 AIILSKAQAQ KYGHLNKNFL IVSEFPSIAF QKCIELFISP VDSGFPGIHP TAVIHPTASI 130 140 150 160 170 180 GKDVCIEPYA VICQHACIGD STYIGTGSVI GAYSTLGEHC LVHPKVVVRE RVEIGKRVII 190 200 210 220 230 240 QPGAVIGSCG FGYITNAFGR HKHLKHLGKV IIEDDVEIGA NTTIDRGRFK NSVIREGTKI 250 260 270 280 290 300 DNQVQIAHHV EVGKHSMIVA QAGIAGSTKI GNHVIIGGQT GITGHISITD HVIMMAQTGV 310 320 330 340 350 TKSISSPGIY GGAPARPYQE IHRQVAKIRS LPKLEERLGM LEEKVKGLSA QSTELQITP

References

[1]

"The Chlamydophila abortus genome sequence reveals an array of variable proteins that contribute to interspecies variation." Thomson N.R., Yeats C., Bell K., Holden M.T.G., Bentley S.D., Livingstone M., Cerdeno-Tarraga A.-M., Harris B., Doggett J., Ormond D., Mungall K., Clarke K., Feltwell T., Hance Z., Sanders M., Quail M.A., Price C., Barrell B.G., Parkhill J., Longbottom D. Genome Res. 15:629-640(2005) [PubMed: 15837807] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: S26/3.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR848038 Genomic DNA. Translation: CAH63919.1.
RefSeq	YP_219880.1. NC_004552.2.
3D structure databases
ProteinModelPortal	Q5L612.
SMR	Q5L612. Positions 7-348.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3337456.
GenomeReviews	Gene locus CAB466 in contig CR848038_GR.
KEGG	cab:CAB466.
PATRIC	20202409. VBIChlAbo21869_0520.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG469615.
OMA	SYPAKIM.
PhylomeDB	Q5L612.
ProtClustDB	PRK00892.
Enzyme and pathway databases
BioCyc	CABO218497:CAB466-MONOMER.
Family and domain databases
HAMAP	MF_00523. LpxD. [Tree]
InterPro	IPR001451. Hexapep_transf. IPR011004. Trimer_LpxA-like. IPR007691. UDP-3-O_GlcNAc_AcTrfase. IPR020573. UDP_GlcNAc_AcTrfase_non-rep. [Graphical view]
KO	K02536.
Pfam	PF00132. Hexapep. 5 hits. PF04613. LpxD. 1 hit. [Graphical view]
SUPFAM	SSF51161. Trimer_LpxA_like. 1 hit.
TIGRFAMs	TIGR01853. Lipid_A_lpxD. 1 hit.
PROSITE	PS00101. HEXAPEP_TRANSFERASES. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LPXD_CHLAB

Accession

Primary (citable) accession number: Q5L612

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	June 21, 2005
Last modified:	January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program