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Q5L5Q6

- SYL_CHLAB

UniProt

Q5L5Q6 - SYL_CHLAB

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Protein
Leucine--tRNA ligase
Gene
leuS, CAB585
Organism
Chlamydophila abortus (strain DSM 27085 / S26/3)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei604 – 6041ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCABO218497:GJB0-601-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:CAB585
OrganismiChlamydophila abortus (strain DSM 27085 / S26/3)
Taxonomic identifieri218497 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydophila
ProteomesiUP000001012: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 820820Leucine--tRNA ligaseUniRule annotation
PRO_1000009319Add
BLAST

Proteomic databases

PRIDEiQ5L5Q6.

Interactioni

Protein-protein interaction databases

STRINGi218497.CAB585.

Structurei

3D structure databases

ProteinModelPortaliQ5L5Q6.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionUniRule annotation
Add
BLAST
Motifi601 – 6055"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiERYWMNV.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5L5Q6-1 [UniParc]FASTAAdd to Basket

« Hide

MRYDPSLIEK KWQQFWKEHK SFKADETADK PKYYVLDMFP YPSGAGLHVG    50
HLIGYTATDI VARYKRAKGF SVLHPMGWDS FGLPAEQYAV RTGTHPRETT 100
KKNIENFRKQ LSAMGFSYDE AREFATSDPE YYRWTQKLFL FLYEKGLAYM 150
ADMAVNYCEE LGTVLANEEV ENGLSIEGGY PVERRMLRQW ILRITAYADQ 200
LLQGLEDLDW PENVKQLQRN WIGKSEGALL RFVVDKDKCL EVFTTRPDTL 250
CGVSFLVMAP EHPEIQQLVS EEQRSAVESY IRCAQSKSER ERISETKVKS 300
GVFTGAYAKH AITGAALPIW VSDYVIMGYG SGVVMGVPAH DERDREFANA 350
FALPIDEVLD ENEHCINSNH GDFLLNGLQG KEASDYVIAY LQKRNLGEAK 400
VMYKLHDWLF SRQRYWGEPI PIIHFEDGTC RPLEDDELPL LPPEIQDYRP 450
KGFGQGPLAK VKEWVDIHDV KTQRPGRRET HTMPQWAGSC WYYLRFCDAH 500
NSQAPWSHEN ERYWMPVDLY IGGAEHAVLH LLYSRFWHRV FYEAGLVSTP 550
EPFKKLINQG LVLATSYRIP GKGYVHPEDA REDNGKWTTA SGEELEVRQE 600
KMSKSKLNGV DPQILIDEFG ADALRMYAMF SGPLDKNKLW CNQGVSGCRR 650
FLNRFYELAT SSAVQDIDDP KGMALAHRLV HKVGEDIEKM SLNTIPSSFM 700
EFINEFAKLD TYSKSALSMV VRALAPIAPH ISEELWTVLG YAPGIDNAGW 750
PEVDPKYLED TSVTFVIQVN GKLRARLDMD KNTSQEDILS AARESVAKYL 800
EDKEIKKEVF VPNRLVNFVL 820
Length:820
Mass (Da):93,863
Last modified:June 21, 2005 - v1
Checksum:i8FD3378BD6A2FBF3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR848038 Genomic DNA. Translation: CAH64033.1.
RefSeqiWP_011097182.1. NC_004552.2.
YP_219986.1. NC_004552.2.

Genome annotation databases

EnsemblBacteriaiCAH64033; CAH64033; CAB585.
GeneIDi3337448.
KEGGicab:CAB585.
PATRICi20202673. VBIChlAbo21869_0644.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR848038 Genomic DNA. Translation: CAH64033.1 .
RefSeqi WP_011097182.1. NC_004552.2.
YP_219986.1. NC_004552.2.

3D structure databases

ProteinModelPortali Q5L5Q6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 218497.CAB585.

Proteomic databases

PRIDEi Q5L5Q6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAH64033 ; CAH64033 ; CAB585 .
GeneIDi 3337448.
KEGGi cab:CAB585.
PATRICi 20202673. VBIChlAbo21869_0644.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi ERYWMNV.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci CABO218497:GJB0-601-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 27085 / S26/3.

Entry informationi

Entry nameiSYL_CHLAB
AccessioniPrimary (citable) accession number: Q5L5Q6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 21, 2005
Last modified: September 3, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi