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Q5L5Q6 (SYL_CHLAB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:CAB585
OrganismChlamydophila abortus (strain DSM 27085 / S26/3) [Complete proteome] [HAMAP]
Taxonomic identifier218497 [NCBI]
Taxonomic lineageBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydophila

Protein attributes

Sequence length820 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 820820Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_1000009319

Regions

Motif40 – 5112"HIGH" region HAMAP-Rule MF_00049
Motif601 – 6055"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6041ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5L5Q6 [UniParc].

Last modified June 21, 2005. Version 1.
Checksum: 8FD3378BD6A2FBF3

FASTA82093,863
        10         20         30         40         50         60 
MRYDPSLIEK KWQQFWKEHK SFKADETADK PKYYVLDMFP YPSGAGLHVG HLIGYTATDI 

        70         80         90        100        110        120 
VARYKRAKGF SVLHPMGWDS FGLPAEQYAV RTGTHPRETT KKNIENFRKQ LSAMGFSYDE 

       130        140        150        160        170        180 
AREFATSDPE YYRWTQKLFL FLYEKGLAYM ADMAVNYCEE LGTVLANEEV ENGLSIEGGY 

       190        200        210        220        230        240 
PVERRMLRQW ILRITAYADQ LLQGLEDLDW PENVKQLQRN WIGKSEGALL RFVVDKDKCL 

       250        260        270        280        290        300 
EVFTTRPDTL CGVSFLVMAP EHPEIQQLVS EEQRSAVESY IRCAQSKSER ERISETKVKS 

       310        320        330        340        350        360 
GVFTGAYAKH AITGAALPIW VSDYVIMGYG SGVVMGVPAH DERDREFANA FALPIDEVLD 

       370        380        390        400        410        420 
ENEHCINSNH GDFLLNGLQG KEASDYVIAY LQKRNLGEAK VMYKLHDWLF SRQRYWGEPI 

       430        440        450        460        470        480 
PIIHFEDGTC RPLEDDELPL LPPEIQDYRP KGFGQGPLAK VKEWVDIHDV KTQRPGRRET 

       490        500        510        520        530        540 
HTMPQWAGSC WYYLRFCDAH NSQAPWSHEN ERYWMPVDLY IGGAEHAVLH LLYSRFWHRV 

       550        560        570        580        590        600 
FYEAGLVSTP EPFKKLINQG LVLATSYRIP GKGYVHPEDA REDNGKWTTA SGEELEVRQE 

       610        620        630        640        650        660 
KMSKSKLNGV DPQILIDEFG ADALRMYAMF SGPLDKNKLW CNQGVSGCRR FLNRFYELAT 

       670        680        690        700        710        720 
SSAVQDIDDP KGMALAHRLV HKVGEDIEKM SLNTIPSSFM EFINEFAKLD TYSKSALSMV 

       730        740        750        760        770        780 
VRALAPIAPH ISEELWTVLG YAPGIDNAGW PEVDPKYLED TSVTFVIQVN GKLRARLDMD 

       790        800        810        820 
KNTSQEDILS AARESVAKYL EDKEIKKEVF VPNRLVNFVL 

« Hide

References

[1]"The Chlamydophila abortus genome sequence reveals an array of variable proteins that contribute to interspecies variation."
Thomson N.R., Yeats C., Bell K., Holden M.T.G., Bentley S.D., Livingstone M., Cerdeno-Tarraga A.-M., Harris B., Doggett J., Ormond D., Mungall K., Clarke K., Feltwell T., Hance Z., Sanders M., Quail M.A., Price C., Barrell B.G., Parkhill J., Longbottom D.
Genome Res. 15:629-640(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 27085 / S26/3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR848038 Genomic DNA. Translation: CAH64033.1.
RefSeqYP_219986.1. NC_004552.2.

3D structure databases

ProteinModelPortalQ5L5Q6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING218497.CAB585.

Proteomic databases

PRIDEQ5L5Q6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAH64033; CAH64033; CAB585.
GeneID3337448.
KEGGcab:CAB585.
PATRIC20202673. VBIChlAbo21869_0644.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200748.
KOK01869.
OMAERYWMNV.
OrthoDBEOG63Z74X.

Enzyme and pathway databases

BioCycCABO218497:GJB0-601-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_CHLAB
AccessionPrimary (citable) accession number: Q5L5Q6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 21, 2005
Last modified: May 14, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries