Q5L5P0 (GSA_CHLAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase
Short name=GSA
EC=5.4.3.8

Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name=GSA-AT

Gene names

Name:	hemL
Ordered Locus Names:	CAB603

Organism

Chlamydophila abortus (strain S26/3) [Complete proteome] [HAMAP]

Taxonomic identifier

218497 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Chlamydiae/Verrucomicrobia group › Chlamydiae › Chlamydiia › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydophila › Chlamydophila abortus

Protein attributes

Sequence length	437 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-4-amino-5-oxopentanoate = 5-aminolevulinate. HAMAP-Rule MF_00375
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2. HAMAP-Rule MF_00375
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm Potential HAMAP-Rule MF_00375.
Sequence similarities	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	chlorophyll biosynthetic process Inferred from electronic annotation. Source: HAMAP protoporphyrinogen IX biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	glutamate-1-semialdehyde 2,1-aminomutase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro transaminase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 437	437	Glutamate-1-semialdehyde 2,1-aminomutase HAMAP-Rule MF_00375		PRO_0000382291
Amino acid modifications
	Modified residue	273	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5L5P0 [UniParc]. Last modified June 21, 2005. Version 1. Checksum: CEFE048BF7AA4392	FASTA	437	47,963
	10 20 30 40 50 60 MPIIEESTMT YAEACRYFPG GVNSPIRACI PVGILPPIVS SAHRDIFIDS FGKTFIDFCG 70 80 90 100 110 120 SWGSLIHGHG HPKILDVICN SASQGTSYGL TSENEISLAA TLFSCLEFED HKVRFVSSGT 130 140 150 160 170 180 EATMTAVRLA CATTGRSIMI KFLGCYHGHA DVLLKGISID ESNIHQVPHI VDTYFSGNPY 190 200 210 220 230 240 LPLNLILPYN DIQIFKEVML QVGERVACVI FEPIAINMGV VLPKPGFIEG VITISRRFAA 250 260 270 280 290 300 LTIMDEVVTG FRMGIRGVRS IMDVDSDITV YGKILGGGMP VAAFLAHHRI MDHLLPLGQV 310 320 330 340 350 360 FQAGTLSGNP IAMAVGKASL ELCREVDFYP KLENLAQSFF APIEEVICHQ GFPVSLVRAG 370 380 390 400 410 420 SMFSFFFRET PPTNLREVQE CDHQMFGVFY RHVFAQGVYL SPAPMEASFL SSVHSKENLA 430 YTQNVLIDSL MKTFGSL

References

[1]

"The Chlamydophila abortus genome sequence reveals an array of variable proteins that contribute to interspecies variation." Thomson N.R., Yeats C., Bell K., Holden M.T.G., Bentley S.D., Livingstone M., Cerdeno-Tarraga A.-M., Harris B., Doggett J., Ormond D., Mungall K., Clarke K., Feltwell T., Hance Z., Sanders M., Quail M.A., Price C., Barrell B.G., Parkhill J., Longbottom D. Genome Res. 15:629-640(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: S26/3.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR848038 Genomic DNA. Translation: CAH64050.1.
RefSeq	YP_220002.1. NC_004552.2.
3D structure databases
HSSP	HSSP built from PDB template 2CFB based on UniProtKB Q8DLK8.
ProteinModelPortal	Q5L5P0.
ModBase	Search...
Protein-protein interaction databases
STRING	218497.CAB603.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAH64050; CAH64050; CAB603.
GeneID	3337995.
KEGG	cab:CAB603.
PATRIC	20202709. VBIChlAbo21869_0662.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0001.
HOGENOM	HOG000020210.
KO	K01845.
OMA	DIFIDSF.
ProtClustDB	PRK00615.
Enzyme and pathway databases
BioCyc	CABO218497:GJB0-618-MONOMER.
UniPathway	UPA00251; UER00317.
Family and domain databases
Gene3D	3.40.640.10. 1 hit. 3.90.1150.10. 2 hits.
HAMAP	MF_00375. HemL_aminotrans_3.
InterPro	IPR004639. 4pyrrol_synth_GluAld_NH2Trfase. IPR005814. Aminotrans_3. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
PANTHER	PTHR11986. PTHR11986. 1 hit. PTHR11986:SF5. PTHR11986:SF5. 1 hit.
Pfam	PF00202. Aminotran_3. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
PROSITE	PS00600. AA_TRANSFER_CLASS_3. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GSA_CHLAB

Accession

Primary (citable) accession number: Q5L5P0

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 1, 2009
Last sequence update:	June 21, 2005
Last modified:	May 1, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program