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Q5L5L8 (TRMD_CHLAB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
tRNA (guanine-N(1)-)-methyltransferase
EC=2.1.1.228
Alternative name(s):
M1G-methyltransferase
tRNA [GM37] methyltransferase
Gene names
Name:trmD
Ordered Locus Names:CAB627
OrganismChlamydophila abortus [Complete proteome] [HAMAP]
Taxonomic identifier83555 [NCBI]
Taxonomic lineageBacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydophila

Protein attributes

Sequence length355 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Specifically methylates guanosine-37 in various tRNAs By similarity. HAMAP MF_00605

Catalytic activity

S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(37) in tRNA. HAMAP MF_00605

Subunit structure

Homodimer By similarity. HAMAP MF_00605

Subcellular location

Cytoplasm Potential HAMAP MF_00605.

Sequence similarities

Belongs to the RNA methyltransferase TrmD family.

Ontologies

Keywords
   Biological processtRNA processing
   Cellular componentCytoplasm
   LigandS-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionRNA binding

Inferred from electronic annotation. Source: InterPro

tRNA (guanine-N1-)-methyltransferase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 355355tRNA (guanine-N(1)-)-methyltransferase HAMAP MF_00605
PRO_0000060356

Regions

Region129 – 1346S-adenosyl-L-methionine binding By similarity

Sites

Binding site1091S-adenosyl-L-methionine; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5L5L8 [UniParc].

Last modified June 21, 2005. Version 1.
Checksum: 0A0840F2ABDA7EC5

FASTA35540,633
        10         20         30         40         50         60 
MKIDILSLFP EYFDSPLRSS ILGRAIKRGL LDIQSRDIRE FGLGKWKQVD DAPFNHDGML 

        70         80         90        100        110        120 
LMAEPVVKAI RHVKRSDSKV VYLSPQGQLL TAKKSRELAQ CSHLIFLCGH YEGIDERALE 

       130        140        150        160        170        180 
SEVDEEISIG DYVLTNGGIA ALVVIDALSR FIPGVLGNQE SADKDSMENG LLEGPQYTRP 

       190        200        210        220        230        240 
RVFEGREVPE VLLHGDHQAI AKWRKQISLD RTRERRPDLY IRYLYDRENE EVTQQETDLK 

       250        260        270        280        290        300 
QSMLEGESAV ILEVEDLHRS RKFYSKMFRL NQPVNNRLHI PGKTQMTIHL QEVGLKSKNI 

       310        320        330        340        350 
VLLSLRLGCK DDFFSFLGRW KMLGGTLEQA DDRGEVRLVR DFDGHVWAIS CKQAE

« Hide

References

[1]"The Chlamydophila abortus genome sequence reveals an array of variable proteins that contribute to interspecies variation."
Thomson N.R., Yeats C., Bell K., Holden M.T.G., Bentley S.D., Livingstone M., Cerdeno-Tarraga A.-M., Harris B., Doggett J., Ormond D., Mungall K., Clarke K., Feltwell T., Hance Z., Sanders M., Quail M.A., Price C., Barrell B.G., Parkhill J., Longbottom D.
Genome Res. 15:629-640(2005) [PubMed: 15837807] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: S26/3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR848038 Genomic DNA. Translation: CAH64073.1.
RefSeqYP_220024.1. NC_004552.2.

3D structure databases

ProteinModelPortalQ5L5L8.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3338221.
GenomeReviewsGene locus CAB627 in contig CR848038_GR.
KEGGcab:CAB627.
PATRIC20202763. VBIChlAbo21869_0688.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG285805.
OMARYLYDRE.
PhylomeDBQ5L5L8.
ProtClustDBPRK01037.

Enzyme and pathway databases

BioCycCABO218497:CAB627-MONOMER.

Family and domain databases

HAMAPMF_00605. TrmD.
[Tree]
InterProIPR016009. tRNA_m1G_MeTrfase.
IPR002649. tRNA_m1G_MeTrfase_bac.
IPR023148. tRNA_m1G_MeTrfase_C.
[Graphical view]
Gene3DG3DSA:1.10.1270.20. tRNA_m1G_MeTrfase_C. 1 hit.
KOK00554.
PANTHERPTHR10056. PTHR10056. 1 hit.
PfamPF01746. tRNA_m1G_MT. 1 hit.
[Graphical view]
TIGRFAMsTIGR00088. TrmD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTRMD_CHLAB
AccessionPrimary (citable) accession number: Q5L5L8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: June 21, 2005
Last modified: January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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