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Q5L5G7 (DAPA_CHLAB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydrodipicolinate synthase
Short name=DHDPS
EC=4.2.1.52
Gene names
Name:dapA
Ordered Locus Names:CAB677
OrganismChlamydophila abortus [Complete proteome] [HAMAP]
Taxonomic identifier83555 [NCBI]
Taxonomic lineageBacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydophila

Protein attributes

Sequence length288 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H2O. HAMAP MF_00418

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4. HAMAP MF_00418

Subunit structure

Homotetramer By similarity. HAMAP MF_00418

Subcellular location

Cytoplasm By similarity HAMAP MF_00418.

Sequence similarities

Belongs to the DHDPS family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Diaminopimelate biosynthesis
Lysine biosynthesis
   Cellular componentCytoplasm
   LigandSchiff base
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processdiaminopimelate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functiondihydrodipicolinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 288288Dihydrodipicolinate synthase HAMAP MF_00418
PRO_0000103097

Sites

Active site1571Schiff-base intermediate with substrate By similarity
Site1291Involved in proton transfer during cleavage By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5L5G7 [UniParc].

Last modified June 21, 2005. Version 1.
Checksum: E9B54C33D3E424B6

FASTA28832,436
        10         20         30         40         50         60 
MKLLTASVTP FLPDHSIDFL SFENLLRFQE RESHGVVLLG STGESLSMTA KEKESLVSYA 

        70         80         90        100        110        120 
CSLNLKVPII VGVPGTSLHE ASEWIHTCQS YPIYGFLITT PIYTKPGVHG QTLWFESLLN 

       130        140        150        160        170        180 
KANKPAILYN IPSRSGTTLY LDTVRSLAAH PFFYGLKDSG GSIKHCQEYA QMSSDFVLYC 

       190        200        210        220        230        240 
GDDGLWPQMY ECGARGLISV LSNIWPKEAR EWVEDPHHQY RADLWREVSS WLNQTTNPIA 

       250        260        270        280 
IKALLAYKQV IAHNTLRLPL SIQDLQCAES IPEIIKKMAQ WKYSCAHV

« Hide

References

[1]"The Chlamydophila abortus genome sequence reveals an array of variable proteins that contribute to interspecies variation."
Thomson N.R., Yeats C., Bell K., Holden M.T.G., Bentley S.D., Livingstone M., Cerdeno-Tarraga A.-M., Harris B., Doggett J., Ormond D., Mungall K., Clarke K., Feltwell T., Hance Z., Sanders M., Quail M.A., Price C., Barrell B.G., Parkhill J., Longbottom D.
Genome Res. 15:629-640(2005) [PubMed: 15837807] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: S26/3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR848038 Genomic DNA. Translation: CAH64124.1.
RefSeqYP_220075.1. NC_004552.2.

3D structure databases

ProteinModelPortalQ5L5G7.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3337639.
GenomeReviewsGene locus CAB677 in contig CR848038_GR.
KEGGcab:CAB677.
PATRIC20202877. VBIChlAbo21869_0742.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG358848.
OMAMSIDINN.
ProtClustDBPRK03170.

Enzyme and pathway databases

BioCycCABO218497:CAB677-MONOMER.

Family and domain databases

HAMAPMF_00418. DapA.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR002220. Dihydrodipicolinate_synth-like.
IPR020625. Dihydrodipicolinate_synth_AS.
IPR020624. Dihydrodipicolinate_synth_CS.
IPR005263. Dihydrodipicolinate_synth_DapA.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK01714.
PANTHERPTHR12128. DHDPS. 1 hit.
PfamPF00701. DHDPS. 1 hit.
[Graphical view]
PIRSFPIRSF001365. DHDPS. 1 hit.
PRINTSPR00146. DHPICSNTHASE.
TIGRFAMsTIGR00674. DapA. 1 hit.
PROSITEPS00665. DHDPS_1. 1 hit.
PS00666. DHDPS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDAPA_CHLAB
AccessionPrimary (citable) accession number: Q5L5G7
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: June 21, 2005
Last modified: January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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