Reviewed, UniProtKB/Swiss-Prot Q5L5E7 (AAXB_CHLAB)

Names and origin

Protein names

Recommended name:
    Pyruvoyl-dependent arginine decarboxylase aaxB
      Short name=PvlArgDC
    EC=4.1.1.19
Alternative name(s):
    Biodegradative arginine decarboxylase
Cleaved into the following 2 chains:
    1- Recommended name:
            Pyruvoyl-dependent arginine decarboxylase subunit beta
    2- Recommended name:
            Pyruvoyl-dependent arginine decarboxylase subunit alpha

Gene names

Name:	aaxB
Ordered Locus Names:	CAB697

Organism

Chlamydophila abortus [Complete proteome] [HAMAP]

Taxonomic identifier

83555 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydophila

Protein attributes

Sequence length	195 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Part of the aaxABC system, catalyzes the decarboxylation of L-arginine. The arginine uptake by the bacterium in the macrophage may be a virulence factor against the host innate immune response By similarity.
Catalytic activity	L-arginine = agmatine + CO2.
Cofactor	Pyruvoyl group By similarity.
Subunit structure	Trimer of an alpha-beta dimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the pyruvoyl-dependent arginine decarboxylase family.

Ontologies

Keywords
Biological process	Virulence
Cellular component	Cytoplasm
Ligand	Pyruvate
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine catabolic process Inferred from electronic annotation. Source: InterPro pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	arginine decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 52	52	Pyruvoyl-dependent arginine decarboxylase subunit beta		PRO_0000364043
	Chain	53 – 195	143	Pyruvoyl-dependent arginine decarboxylase subunit alpha		PRO_0000364044
Sites
	Site	52 – 53	2	Cleavage (non-hydrolytic) By similarity
Amino acid modifications
	Modified residue	53	1	Pyruvic acid (Ser) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5L5E7-1 [UniParc]. Last modified June 21, 2005. Version 1. Checksum: A81BEBE617A50B90	FASTA	195	21,831
	10 20 30 40 50 60 MPYGTRYPTL AFHTGGVGES DDGMPPQPFE TFCYDSALLQ AKIENFNIVP YTSVLPKELF 70 80 90 100 110 120 GNIVPVDQCV KFFKHGAVLE VIMAGRGAST VEGTHAITTG VGICWGQDKN GELIGGWAAE 130 140 150 160 170 180 YVEFFPTWIN DEIAESHAKM WLKKSLQHEL DLRSVVKHSE FQYFHNYINI KQKYGFSLTA 190 LGFLNFENAD PVTIK

References

[1]

"The Chlamydophila abortus genome sequence reveals an array of variable proteins that contribute to interspecies variation." Thomson N.R., Yeats C., Bell K., Holden M.T.G., Bentley S.D., Livingstone M., Cerdeno-Tarraga A.-M., Harris B., Doggett J., Ormond D., Mungall K., Clarke K., Feltwell T., Hance Z., Sanders M., Quail M.A., Price C., Barrell B.G., Parkhill J., Longbottom D. Genome Res. 15:629-640(2005) [PubMed: 15837807] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: S26/3.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR848038 Genomic DNA. Translation: CAH64144.1.
RefSeq	YP_220095.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3337603.
GenomeReviews	Gene locus CAB697 in contig CR848038_GR.
KEGG	cab:CAB697.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG414056.
OMA	VEFFPTW.
Enzyme and pathway databases
BioCyc	CABO218497:CAB697-MONOMER.
Family and domain databases
InterPro	IPR016104. Pyr-dep_his/arg-deCO2ase. IPR016105. Pyr-dep_his/arg-deCO2ase_sand. IPR002724. Pyruvoyl-dep_arg_deCO2ase. [Graphical view]
Gene3D	G3DSA:3.50.20.10. Pyr-dep_his/arg-deCO2ase_sand. 1 hit.
Pfam	PF01862. PvlArgDC. 1 hit. [Graphical view]
ProDom	PD010449. Pyruvoyl-dep_arg_deCO2ase. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

AAXB_CHLAB

Accession

Primary (citable) accession number: Q5L5E7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	June 21, 2005
Last modified:	January 19, 2010
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)