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Protein

Pyruvoyl-dependent arginine decarboxylase AaxB

Gene

aaxB

Organism
Chlamydia abortus (strain DSM 27085 / S26/3) (Chlamydophila abortus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Part of the AaxABC system, catalyzes the decarboxylation of L-arginine. The arginine uptake by the bacterium in the macrophage may be a virulence factor against the host innate immune response (By similarity).By similarity

Catalytic activityi

L-arginine = agmatine + CO2.

Cofactori

pyruvateBy similarityNote: Binds 1 pyruvoyl group covalently per subunit.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Virulence

Keywords - Ligandi

Pyruvate

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvoyl-dependent arginine decarboxylase AaxB (EC:4.1.1.19)
Short name:
PvlArgDC
Alternative name(s):
Biodegradative arginine decarboxylase
Cleaved into the following 2 chains:
Gene namesi
Name:aaxB
Ordered Locus Names:CAB697
OrganismiChlamydia abortus (strain DSM 27085 / S26/3) (Chlamydophila abortus)
Taxonomic identifieri218497 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000001012 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003640431 – 52Pyruvoyl-dependent arginine decarboxylase subunit betaAdd BLAST52
ChainiPRO_000036404453 – 195Pyruvoyl-dependent arginine decarboxylase subunit alphaAdd BLAST143

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei53Pyruvic acid (Ser)By similarity1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei52 – 53Cleavage (non-hydrolytic)By similarity2

Interactioni

Subunit structurei

Trimer of an alpha-beta dimer.By similarity

Protein-protein interaction databases

STRINGi218497.CAB697.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108PHJ. Bacteria.
COG1945. LUCA.
HOGENOMiHOG000025218.
KOiK02626.
OMAiKKKFGFC.
OrthoDBiPOG091H1TON.

Family and domain databases

Gene3Di3.50.20.10. 1 hit.
InterProiIPR016104. Pyr-dep_his/arg-deCO2ase.
IPR016105. Pyr-dep_his/arg-deCO2ase_sand.
IPR002724. Pyruvoyl-dep_arg_deCO2ase.
[Graphical view]
PfamiPF01862. PvlArgDC. 1 hit.
[Graphical view]
ProDomiPD010449. Pyruvoyl-dep_arg_deCO2ase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF56271. SSF56271. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5L5E7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYGTRYPTL AFHTGGVGES DDGMPPQPFE TFCYDSALLQ AKIENFNIVP
60 70 80 90 100
YTSVLPKELF GNIVPVDQCV KFFKHGAVLE VIMAGRGAST VEGTHAITTG
110 120 130 140 150
VGICWGQDKN GELIGGWAAE YVEFFPTWIN DEIAESHAKM WLKKSLQHEL
160 170 180 190
DLRSVVKHSE FQYFHNYINI KQKYGFSLTA LGFLNFENAD PVTIK
Length:195
Mass (Da):21,831
Last modified:June 21, 2005 - v1
Checksum:iA81BEBE617A50B90
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR848038 Genomic DNA. Translation: CAH64144.1.
RefSeqiWP_011097272.1. NC_004552.2.

Genome annotation databases

EnsemblBacteriaiCAH64144; CAH64144; CAB697.
KEGGicab:CAB697.
PATRICi20202917. VBIChlAbo21869_0762.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR848038 Genomic DNA. Translation: CAH64144.1.
RefSeqiWP_011097272.1. NC_004552.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi218497.CAB697.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAH64144; CAH64144; CAB697.
KEGGicab:CAB697.
PATRICi20202917. VBIChlAbo21869_0762.

Phylogenomic databases

eggNOGiENOG4108PHJ. Bacteria.
COG1945. LUCA.
HOGENOMiHOG000025218.
KOiK02626.
OMAiKKKFGFC.
OrthoDBiPOG091H1TON.

Family and domain databases

Gene3Di3.50.20.10. 1 hit.
InterProiIPR016104. Pyr-dep_his/arg-deCO2ase.
IPR016105. Pyr-dep_his/arg-deCO2ase_sand.
IPR002724. Pyruvoyl-dep_arg_deCO2ase.
[Graphical view]
PfamiPF01862. PvlArgDC. 1 hit.
[Graphical view]
ProDomiPD010449. Pyruvoyl-dep_arg_deCO2ase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF56271. SSF56271. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAAXB_CHLAB
AccessioniPrimary (citable) accession number: Q5L5E7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: June 21, 2005
Last modified: November 2, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.