Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q5L5E7

- AAXB_CHLAB

UniProt

Q5L5E7 - AAXB_CHLAB

Protein

Pyruvoyl-dependent arginine decarboxylase AaxB

Gene

aaxB

Organism
Chlamydophila abortus (strain DSM 27085 / S26/3)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (21 Jun 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Part of the AaxABC system, catalyzes the decarboxylation of L-arginine. The arginine uptake by the bacterium in the macrophage may be a virulence factor against the host innate immune response By similarity.By similarity

    Catalytic activityi

    L-arginine = agmatine + CO2.

    Cofactori

    Pyruvoyl group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei52 – 532Cleavage (non-hydrolytic)By similarity

    GO - Molecular functioni

    1. arginine decarboxylase activity Source: UniProtKB-EC

    GO - Biological processi

    1. arginine catabolic process Source: InterPro
    2. pathogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Virulence

    Keywords - Ligandi

    Pyruvate

    Enzyme and pathway databases

    BioCyciCABO218497:GJB0-717-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyruvoyl-dependent arginine decarboxylase AaxB (EC:4.1.1.19)
    Short name:
    PvlArgDC
    Alternative name(s):
    Biodegradative arginine decarboxylase
    Cleaved into the following 2 chains:
    Gene namesi
    Name:aaxB
    Ordered Locus Names:CAB697
    OrganismiChlamydophila abortus (strain DSM 27085 / S26/3)
    Taxonomic identifieri218497 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydophila
    ProteomesiUP000001012: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 5252Pyruvoyl-dependent arginine decarboxylase subunit betaPRO_0000364043Add
    BLAST
    Chaini53 – 195143Pyruvoyl-dependent arginine decarboxylase subunit alphaPRO_0000364044Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei53 – 531Pyruvic acid (Ser)By similarity

    Interactioni

    Subunit structurei

    Trimer of an alpha-beta dimer.By similarity

    Protein-protein interaction databases

    STRINGi218497.CAB697.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1945.
    HOGENOMiHOG000025218.
    OMAiWAVEYVE.
    OrthoDBiEOG6Q5NT3.

    Family and domain databases

    Gene3Di3.50.20.10. 1 hit.
    InterProiIPR016104. Pyr-dep_his/arg-deCO2ase.
    IPR016105. Pyr-dep_his/arg-deCO2ase_sand.
    IPR002724. Pyruvoyl-dep_arg_deCO2ase.
    [Graphical view]
    PfamiPF01862. PvlArgDC. 1 hit.
    [Graphical view]
    ProDomiPD010449. Pyruvoyl-dep_arg_deCO2ase. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF56271. SSF56271. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5L5E7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPYGTRYPTL AFHTGGVGES DDGMPPQPFE TFCYDSALLQ AKIENFNIVP    50
    YTSVLPKELF GNIVPVDQCV KFFKHGAVLE VIMAGRGAST VEGTHAITTG 100
    VGICWGQDKN GELIGGWAAE YVEFFPTWIN DEIAESHAKM WLKKSLQHEL 150
    DLRSVVKHSE FQYFHNYINI KQKYGFSLTA LGFLNFENAD PVTIK 195
    Length:195
    Mass (Da):21,831
    Last modified:June 21, 2005 - v1
    Checksum:iA81BEBE617A50B90
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR848038 Genomic DNA. Translation: CAH64144.1.
    RefSeqiYP_220095.1. NC_004552.2.

    Genome annotation databases

    EnsemblBacteriaiCAH64144; CAH64144; CAB697.
    GeneIDi3337603.
    KEGGicab:CAB697.
    PATRICi20202917. VBIChlAbo21869_0762.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR848038 Genomic DNA. Translation: CAH64144.1 .
    RefSeqi YP_220095.1. NC_004552.2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 218497.CAB697.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAH64144 ; CAH64144 ; CAB697 .
    GeneIDi 3337603.
    KEGGi cab:CAB697.
    PATRICi 20202917. VBIChlAbo21869_0762.

    Phylogenomic databases

    eggNOGi COG1945.
    HOGENOMi HOG000025218.
    OMAi WAVEYVE.
    OrthoDBi EOG6Q5NT3.

    Enzyme and pathway databases

    BioCyci CABO218497:GJB0-717-MONOMER.

    Family and domain databases

    Gene3Di 3.50.20.10. 1 hit.
    InterProi IPR016104. Pyr-dep_his/arg-deCO2ase.
    IPR016105. Pyr-dep_his/arg-deCO2ase_sand.
    IPR002724. Pyruvoyl-dep_arg_deCO2ase.
    [Graphical view ]
    Pfami PF01862. PvlArgDC. 1 hit.
    [Graphical view ]
    ProDomi PD010449. Pyruvoyl-dep_arg_deCO2ase. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF56271. SSF56271. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 27085 / S26/3.

    Entry informationi

    Entry nameiAAXB_CHLAB
    AccessioniPrimary (citable) accession number: Q5L5E7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 10, 2009
    Last sequence update: June 21, 2005
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3