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Q5L5E3

- MDH_CHLAB

UniProt

Q5L5E3 - MDH_CHLAB

Protein

Malate dehydrogenase

Gene

mdh

Organism
Chlamydophila abortus (strain DSM 27085 / S26/3)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (21 Jun 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei96 – 961SubstrateUniRule annotation
    Binding sitei102 – 1021SubstrateUniRule annotation
    Binding sitei109 – 1091NADUniRule annotation
    Binding sitei116 – 1161NADUniRule annotation
    Binding sitei135 – 1351SubstrateUniRule annotation
    Binding sitei166 – 1661SubstrateUniRule annotation
    Active sitei191 – 1911Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi15 – 217NADUniRule annotation
    Nucleotide bindingi133 – 1353NADUniRule annotation

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciCABO218497:GJB0-721-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
    Gene namesi
    Name:mdhUniRule annotation
    Ordered Locus Names:CAB701
    OrganismiChlamydophila abortus (strain DSM 27085 / S26/3)
    Taxonomic identifieri218497 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydophila
    ProteomesiUP000001012: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 330330Malate dehydrogenasePRO_0000113355Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi218497.CAB701.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5L5E3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 2 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0039.
    HOGENOMiHOG000220953.
    KOiK00024.
    OMAiWLENIMI.
    OrthoDBiEOG6PP9Q2.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPiMF_01517. Malate_dehydrog_2.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR010945. Malate_DH_type2.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23382. PTHR23382. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    SUPFAMiSSF56327. SSF56327. 1 hit.
    TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5L5E3-1 [UniParc]FASTAAdd to Basket

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    MVMKLTRTVS VAVTGGTGQI AYSFLFALAH GDVFGSDCGI DLRIYDLPGL    50
    ERVLSGVRME LDDGAYPLLQ SLRVTTSLED AFDGIDAAFL IGAAPRGPGM 100
    ERSDLLKRNG EIFSLQGSVL NTSAKRDAKI FVVGNPVNTN CWIAMSQAPR 150
    LNRRNFHSML RLDQNRMHTM LAHRAEVPLD EVSHVVIWGN HSAKQVPDFT 200
    QALISGKPAV EVIGDRDWLE NIMLPSIQNR GSAVIEARGK SSAASAARAL 250
    AEAARSIFLP KDGEWFSTGV CSDYNPYGIP EDLIFGFPCR MLPSGDYEIV 300
    PGLLWDTFIK NKIQISLDEI SQEKANVSLL 330
    Length:330
    Mass (Da):36,110
    Last modified:June 21, 2005 - v1
    Checksum:i11209B9C49E7B1D3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR848038 Genomic DNA. Translation: CAH64148.1.
    RefSeqiWP_011097275.1. NC_004552.2.
    YP_220099.1. NC_004552.2.

    Genome annotation databases

    EnsemblBacteriaiCAH64148; CAH64148; CAB701.
    GeneIDi3337606.
    KEGGicab:CAB701.
    PATRICi20202925. VBIChlAbo21869_0766.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR848038 Genomic DNA. Translation: CAH64148.1 .
    RefSeqi WP_011097275.1. NC_004552.2.
    YP_220099.1. NC_004552.2.

    3D structure databases

    ProteinModelPortali Q5L5E3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 218497.CAB701.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAH64148 ; CAH64148 ; CAB701 .
    GeneIDi 3337606.
    KEGGi cab:CAB701.
    PATRICi 20202925. VBIChlAbo21869_0766.

    Phylogenomic databases

    eggNOGi COG0039.
    HOGENOMi HOG000220953.
    KOi K00024.
    OMAi WLENIMI.
    OrthoDBi EOG6PP9Q2.

    Enzyme and pathway databases

    BioCyci CABO218497:GJB0-721-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPi MF_01517. Malate_dehydrog_2.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR010945. Malate_DH_type2.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23382. PTHR23382. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    TIGRFAMsi TIGR01759. MalateDH-SF1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 27085 / S26/3.

    Entry informationi

    Entry nameiMDH_CHLAB
    AccessioniPrimary (citable) accession number: Q5L5E3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2005
    Last sequence update: June 21, 2005
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3