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Q5L5E3

- MDH_CHLAB

UniProt

Q5L5E3 - MDH_CHLAB

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Protein
Malate dehydrogenase
Gene
mdh, CAB701
Organism
Chlamydophila abortus (strain DSM 27085 / S26/3)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei96 – 961Substrate By similarity
Binding sitei102 – 1021Substrate By similarity
Binding sitei109 – 1091NAD By similarity
Binding sitei116 – 1161NAD By similarity
Binding sitei135 – 1351Substrate By similarity
Binding sitei166 – 1661Substrate By similarity
Active sitei191 – 1911Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 217NAD By similarity
Nucleotide bindingi133 – 1353NAD By similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciCABO218497:GJB0-721-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
Ordered Locus Names:CAB701
OrganismiChlamydophila abortus (strain DSM 27085 / S26/3)
Taxonomic identifieri218497 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydophila
ProteomesiUP000001012: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 330330Malate dehydrogenaseUniRule annotation
PRO_0000113355Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi218497.CAB701.

Structurei

3D structure databases

ProteinModelPortaliQ5L5E3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000220953.
KOiK00024.
OMAiWLENIMI.
OrthoDBiEOG6PP9Q2.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_01517. Malate_dehydrog_2.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23382. PTHR23382. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5L5E3-1 [UniParc]FASTAAdd to Basket

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MVMKLTRTVS VAVTGGTGQI AYSFLFALAH GDVFGSDCGI DLRIYDLPGL    50
ERVLSGVRME LDDGAYPLLQ SLRVTTSLED AFDGIDAAFL IGAAPRGPGM 100
ERSDLLKRNG EIFSLQGSVL NTSAKRDAKI FVVGNPVNTN CWIAMSQAPR 150
LNRRNFHSML RLDQNRMHTM LAHRAEVPLD EVSHVVIWGN HSAKQVPDFT 200
QALISGKPAV EVIGDRDWLE NIMLPSIQNR GSAVIEARGK SSAASAARAL 250
AEAARSIFLP KDGEWFSTGV CSDYNPYGIP EDLIFGFPCR MLPSGDYEIV 300
PGLLWDTFIK NKIQISLDEI SQEKANVSLL 330
Length:330
Mass (Da):36,110
Last modified:June 21, 2005 - v1
Checksum:i11209B9C49E7B1D3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR848038 Genomic DNA. Translation: CAH64148.1.
RefSeqiWP_011097275.1. NC_004552.2.
YP_220099.1. NC_004552.2.

Genome annotation databases

EnsemblBacteriaiCAH64148; CAH64148; CAB701.
GeneIDi3337606.
KEGGicab:CAB701.
PATRICi20202925. VBIChlAbo21869_0766.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR848038 Genomic DNA. Translation: CAH64148.1 .
RefSeqi WP_011097275.1. NC_004552.2.
YP_220099.1. NC_004552.2.

3D structure databases

ProteinModelPortali Q5L5E3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 218497.CAB701.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAH64148 ; CAH64148 ; CAB701 .
GeneIDi 3337606.
KEGGi cab:CAB701.
PATRICi 20202925. VBIChlAbo21869_0766.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000220953.
KOi K00024.
OMAi WLENIMI.
OrthoDBi EOG6PP9Q2.

Enzyme and pathway databases

BioCyci CABO218497:GJB0-721-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_01517. Malate_dehydrog_2.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23382. PTHR23382. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01759. MalateDH-SF1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 27085 / S26/3.

Entry informationi

Entry nameiMDH_CHLAB
AccessioniPrimary (citable) accession number: Q5L5E3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: June 21, 2005
Last modified: September 3, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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