Q5L5E1 (G6PI_CHLAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	CAB703

Organism

Chlamydophila abortus [Complete proteome] [HAMAP]

Taxonomic identifier

83555 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydophila

Protein attributes

Sequence length	530 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity HAMAP MF_00473.
Sequence similarities	Belongs to the GPI family.
Sequence caution	The sequence CAH64150.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 530	530	Glucose-6-phosphate isomerase HAMAP MF_00473		PRO_0000180621
Sites
	Active site	347	1	Proton donor By similarity
	Active site	378	1	By similarity
	Active site	493	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5L5E1 [UniParc]. Last modified November 8, 2005. Version 2. Checksum: DFD695D0CC1B7138	FASTA	530	57,820
	10 20 30 40 50 60 MDRKGFLDSP STKILQDLAV APVDLTTPGI ISQERVERFS LSIGGFTLSY ATERVDEGVV 70 80 90 100 110 120 SALTDLASER GLVSSMQAMQ SGEVVNYIDN FPSESRPALH TATRAWVKEI PLTGNAEDIA 130 140 150 160 170 180 LRSKIEAQRL KDFLHQYRDA FTTIVQIGIG GSELGPKALH RALKGCCPSD KKVYFVSNID 190 200 210 220 230 240 PDNAAEVLQE IDCSKTLVVT VSKSGTTLET AVNEEFIADH FLKQGLHFRD HFIAVTCEGS 250 260 270 280 290 300 PMDDRSKYLE VFHIWDSIGG RYSSTSMVGG VVLGFAYGFD VFFQLLEGAA AMDLAALAPQ 310 320 330 340 350 360 MSENLPMLAA MLGIWNRNFL GYPTSVIVPY SAGLEYFPAH LQQCGMESNG KSIAQTGEII 370 380 390 400 410 420 GFATSPILWG EVGTNSQHSF FQCLHQGSDV IPIEFIGFLD NQRGRDIVIS GSTSSQKLFA 430 440 450 460 470 480 NMVAQSIALA KGRENTNPNK SFRGNRPSSL LVAERLTPYT MGALLAFYEH KIVFQGFCWG 490 500 510 520 530 INSFDQEGVT LGKDLANQVL GIMQGQAKEG ACLEAEALLK LFNSTQKKKS

References

[1]

"The Chlamydophila abortus genome sequence reveals an array of variable proteins that contribute to interspecies variation." Thomson N.R., Yeats C., Bell K., Holden M.T.G., Bentley S.D., Livingstone M., Cerdeno-Tarraga A.-M., Harris B., Doggett J., Ormond D., Mungall K., Clarke K., Feltwell T., Hance Z., Sanders M., Quail M.A., Price C., Barrell B.G., Parkhill J., Longbottom D. Genome Res. 15:629-640(2005) [PubMed: 15837807] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: S26/3.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR848038 Genomic DNA. Translation: CAH64150.1. Different initiation.
RefSeq	YP_220101.1. NC_004552.2.
3D structure databases
ProteinModelPortal	Q5L5E1.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3337661.
GenomeReviews	Gene locus CAB703 in contig CR848038_GR.
KEGG	cab:CAB703.
PATRIC	20202929. VBIChlAbo21869_0768.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG352954.
OMA	NSLPAWT.
PhylomeDB	Q5L5E1.
ProtClustDB	PRK14095.
Enzyme and pathway databases
BioCyc	CABO218497:CAB703-MONOMER.
Family and domain databases
HAMAP	MF_00473. G6P_isomerase. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR023096. G6P_Isomerase_C. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
Gene3D	G3DSA:1.10.1390.10. G6P_Isomerase_C. 1 hit.
KO	K01810.
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_CHLAB

Accession

Primary (citable) accession number: Q5L5E1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2005
Last sequence update:	November 8, 2005
Last modified:	January 25, 2012
This is version 40 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program