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Q5L5E1 (G6PI_CHLAB) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase

Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi
Ordered Locus Names:CAB703
OrganismChlamydophila abortus (strain DSM 27085 / S26/3) [Complete proteome] [HAMAP]
Taxonomic identifier218497 [NCBI]
Taxonomic lineageBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydophila

Protein attributes

Sequence length530 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00473.

Sequence similarities

Belongs to the GPI family.

Sequence caution

The sequence CAH64150.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glycolytic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 530530Glucose-6-phosphate isomerase HAMAP-Rule MF_00473
PRO_0000180621

Sites

Active site3471Proton donor By similarity
Active site3781 By similarity
Active site4931 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5L5E1 [UniParc].

Last modified November 8, 2005. Version 2.
Checksum: DFD695D0CC1B7138

FASTA53057,820
        10         20         30         40         50         60 
MDRKGFLDSP STKILQDLAV APVDLTTPGI ISQERVERFS LSIGGFTLSY ATERVDEGVV 

        70         80         90        100        110        120 
SALTDLASER GLVSSMQAMQ SGEVVNYIDN FPSESRPALH TATRAWVKEI PLTGNAEDIA 

       130        140        150        160        170        180 
LRSKIEAQRL KDFLHQYRDA FTTIVQIGIG GSELGPKALH RALKGCCPSD KKVYFVSNID 

       190        200        210        220        230        240 
PDNAAEVLQE IDCSKTLVVT VSKSGTTLET AVNEEFIADH FLKQGLHFRD HFIAVTCEGS 

       250        260        270        280        290        300 
PMDDRSKYLE VFHIWDSIGG RYSSTSMVGG VVLGFAYGFD VFFQLLEGAA AMDLAALAPQ 

       310        320        330        340        350        360 
MSENLPMLAA MLGIWNRNFL GYPTSVIVPY SAGLEYFPAH LQQCGMESNG KSIAQTGEII 

       370        380        390        400        410        420 
GFATSPILWG EVGTNSQHSF FQCLHQGSDV IPIEFIGFLD NQRGRDIVIS GSTSSQKLFA 

       430        440        450        460        470        480 
NMVAQSIALA KGRENTNPNK SFRGNRPSSL LVAERLTPYT MGALLAFYEH KIVFQGFCWG 

       490        500        510        520        530 
INSFDQEGVT LGKDLANQVL GIMQGQAKEG ACLEAEALLK LFNSTQKKKS 

« Hide

References

[1]"The Chlamydophila abortus genome sequence reveals an array of variable proteins that contribute to interspecies variation."
Thomson N.R., Yeats C., Bell K., Holden M.T.G., Bentley S.D., Livingstone M., Cerdeno-Tarraga A.-M., Harris B., Doggett J., Ormond D., Mungall K., Clarke K., Feltwell T., Hance Z., Sanders M., Quail M.A., Price C., Barrell B.G., Parkhill J., Longbottom D.
Genome Res. 15:629-640(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 27085 / S26/3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR848038 Genomic DNA. Translation: CAH64150.1. Different initiation.
RefSeqYP_220101.1. NC_004552.2.

3D structure databases

ProteinModelPortalQ5L5E1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING218497.CAB703.

Proteomic databases

PRIDEQ5L5E1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAH64150; CAH64150; CAB703.
GeneID3337661.
KEGGcab:CAB703.
PATRIC20202929. VBIChlAbo21869_0768.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0166.
HOGENOMHOG000261370.
KOK01810.
OMAISIYESN.
OrthoDBEOG64R61J.

Enzyme and pathway databases

BioCycCABO218497:GJB0-723-MONOMER.
UniPathwayUPA00109; UER00181.

Family and domain databases

Gene3D1.10.1390.10. 1 hit.
HAMAPMF_00473. G6P_isomerase.
InterProIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERPTHR11469. PTHR11469. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_CHLAB
AccessionPrimary (citable) accession number: Q5L5E1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: June 11, 2014
This is version 58 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways