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Q5L5B4

- PNP_CHLAB

UniProt

Q5L5B4 - PNP_CHLAB

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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp, CAB730
Organism
Chlamydophila abortus (strain DSM 27085 / S26/3)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi485 – 4851Magnesium By similarity
Metal bindingi491 – 4911Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. RNA binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. RNA processing Source: InterPro
  2. mRNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciCABO218497:GJB0-751-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:CAB730
OrganismiChlamydophila abortus (strain DSM 27085 / S26/3)
Taxonomic identifieri218497 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydophila
ProteomesiUP000001012: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 694694Polyribonucleotide nucleotidyltransferaseUniRule annotation
PRO_0000329582Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi218497.CAB730.

Structurei

3D structure databases

ProteinModelPortaliQ5L5B4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini552 – 61160KH
Add
BLAST
Domaini621 – 68969S1 motif
Add
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiQAKEGRQ.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5L5B4-1 [UniParc]FASTAAdd to Basket

« Hide

MTFETISVTL EEGKTLVFET GKIARQANGA VLARMQETWV FSSVCAANLE    50
EAVDFLPLRV DYQEKFSSIG KTLGGFIKRE GRPTEREILT SRLIDRSMRP 100
SLPNRLMQDI QILSYVWSYD GVTLPDPIAI CGVSAALAIS DIPQTSIVAG 150
VRVGFVNNRW VVNPTKAEMD VSRMELVLAG TENAILMIEG HCDFFTEEQV 200
IEAIEFGHKH IVTICKALKD WQKHIGKEKN TSGIVSLPEE VQSAVNTFVE 250
GKFVDLLKIK EKKAFEAASK QLENEVIEQL QEENEVFTAF NIKIAFKQAK 300
SNFIRGLIRE QGLRSDGRSV TTIRPISIDT SFLPRTHGSC LFTRGETQTM 350
AVCTLGSEAM AQRYEDLNGE GLAKFYLQYF FPPFSVGEVG RIGSPGRREI 400
GHGKLAEKAL SHTLPDPMKF PYTIRIESNI TESNGSSSMA SVCGGCLALM 450
DAGVPIKTPI AGIAMGLILE DDHVTILSDI SGLEDHLGDM DFKVAGNTEG 500
ITAFQMDIKV EGITPDIMRA ALAQAKEGRQ DILETMKQAL AAPKTDLSQY 550
APRIETMQIK PNKIATVIGP GGKQIRQIIE EAGVQIDIND SGLVSISASS 600
PQAIEKAKSI IEGLVGEVEV GKIYEGRVTS VVPFGAFVEI LPGKEGLCHI 650
SEFSKQRIDN VGDFVKQGDT LTVKLLSINE KGQYKLSHKA TLSE 694
Length:694
Mass (Da):75,995
Last modified:June 21, 2005 - v1
Checksum:i4734BF456D52DF85
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR848038 Genomic DNA. Translation: CAH64177.1.
RefSeqiYP_220128.1. NC_004552.2.

Genome annotation databases

EnsemblBacteriaiCAH64177; CAH64177; CAB730.
GeneIDi3338065.
KEGGicab:CAB730.
PATRICi20202983. VBIChlAbo21869_0794.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR848038 Genomic DNA. Translation: CAH64177.1 .
RefSeqi YP_220128.1. NC_004552.2.

3D structure databases

ProteinModelPortali Q5L5B4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 218497.CAB730.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAH64177 ; CAH64177 ; CAB730 .
GeneIDi 3338065.
KEGGi cab:CAB730.
PATRICi 20202983. VBIChlAbo21869_0794.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi QAKEGRQ.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci CABO218497:GJB0-751-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 27085 / S26/3.

Entry informationi

Entry nameiPNP_CHLAB
AccessioniPrimary (citable) accession number: Q5L5B4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: June 21, 2005
Last modified: May 14, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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