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Q5L5A2

- TRMB_CHLAB

UniProt

Q5L5A2 - TRMB_CHLAB

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, CAB743
Organism
Chlamydophila abortus (strain DSM 27085 / S26/3)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei54 – 541S-adenosyl-L-methionine By similarity
Binding sitei79 – 791S-adenosyl-L-methionine By similarity
Binding sitei106 – 1061S-adenosyl-L-methionine By similarity
Active sitei129 – 1291 By similarity
Binding sitei129 – 1291S-adenosyl-L-methionine By similarity
Binding sitei133 – 1331Substrate By similarity
Binding sitei165 – 1651Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciCABO218497:GJB0-766-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:CAB743
OrganismiChlamydophila abortus (strain DSM 27085 / S26/3)
Taxonomic identifieri218497 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydophila
ProteomesiUP000001012: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 224224tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
PRO_0000229160Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi218497.CAB743.

Structurei

3D structure databases

ProteinModelPortaliQ5L5A2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000034940.
KOiK03439.
OMAiIVELAMN.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5L5A2-1 [UniParc]FASTAAdd to Basket

« Hide

MKPQDLKAPF FGEERKTQIK DDVLYIPEHY FKHGQFEMPS WEEFFGNNHP    50
IFCELCSGNG DWVVAQANKN PNMNWIAVEK RFDRVRKIWS KMHNSQVRNL 100
RIVCGEAQTF FRHYIQNEVI QRIVVNFPDP WPKSRHRKHR LFQYEFMNDI 150
VRVLVDSGII ILATDDKNYL LQAIKIMQQR LLPKLEEPYY CKMLENYGDS 200
WFERLWRSKG QEIFYTEFVK KVGI 224
Length:224
Mass (Da):27,042
Last modified:June 21, 2005 - v1
Checksum:i667E8581228882A9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR848038 Genomic DNA. Translation: CAH64190.1.
RefSeqiWP_011097308.1. NC_004552.2.
YP_220140.1. NC_004552.2.

Genome annotation databases

EnsemblBacteriaiCAH64190; CAH64190; CAB743.
GeneIDi3337857.
KEGGicab:CAB743.
PATRICi20203015. VBIChlAbo21869_0808.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR848038 Genomic DNA. Translation: CAH64190.1 .
RefSeqi WP_011097308.1. NC_004552.2.
YP_220140.1. NC_004552.2.

3D structure databases

ProteinModelPortali Q5L5A2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 218497.CAB743.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAH64190 ; CAH64190 ; CAB743 .
GeneIDi 3337857.
KEGGi cab:CAB743.
PATRICi 20203015. VBIChlAbo21869_0808.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000034940.
KOi K03439.
OMAi IVELAMN.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci CABO218497:GJB0-766-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 27085 / S26/3.

Entry informationi

Entry nameiTRMB_CHLAB
AccessioniPrimary (citable) accession number: Q5L5A2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: June 21, 2005
Last modified: September 3, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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