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Q5L5A2

- TRMB_CHLAB

UniProt

Q5L5A2 - TRMB_CHLAB

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Chlamydophila abortus (strain DSM 27085 / S26/3)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (21 Jun 2005)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei54 – 541S-adenosyl-L-methionineUniRule annotation
    Binding sitei79 – 791S-adenosyl-L-methionineUniRule annotation
    Binding sitei106 – 1061S-adenosyl-L-methionineUniRule annotation
    Active sitei129 – 1291By similarity
    Binding sitei129 – 1291S-adenosyl-L-methionineUniRule annotation
    Binding sitei133 – 1331SubstrateUniRule annotation
    Binding sitei165 – 1651SubstrateUniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciCABO218497:GJB0-766-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
    tRNA(m7G46)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmBUniRule annotation
    Ordered Locus Names:CAB743
    OrganismiChlamydophila abortus (strain DSM 27085 / S26/3)
    Taxonomic identifieri218497 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydophila
    ProteomesiUP000001012: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 224224tRNA (guanine-N(7)-)-methyltransferasePRO_0000229160Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi218497.CAB743.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5L5A2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000034940.
    KOiK03439.
    OMAiIVELAMN.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5L5A2-1 [UniParc]FASTAAdd to Basket

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    MKPQDLKAPF FGEERKTQIK DDVLYIPEHY FKHGQFEMPS WEEFFGNNHP    50
    IFCELCSGNG DWVVAQANKN PNMNWIAVEK RFDRVRKIWS KMHNSQVRNL 100
    RIVCGEAQTF FRHYIQNEVI QRIVVNFPDP WPKSRHRKHR LFQYEFMNDI 150
    VRVLVDSGII ILATDDKNYL LQAIKIMQQR LLPKLEEPYY CKMLENYGDS 200
    WFERLWRSKG QEIFYTEFVK KVGI 224
    Length:224
    Mass (Da):27,042
    Last modified:June 21, 2005 - v1
    Checksum:i667E8581228882A9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR848038 Genomic DNA. Translation: CAH64190.1.
    RefSeqiWP_011097308.1. NC_004552.2.
    YP_220140.1. NC_004552.2.

    Genome annotation databases

    EnsemblBacteriaiCAH64190; CAH64190; CAB743.
    GeneIDi3337857.
    KEGGicab:CAB743.
    PATRICi20203015. VBIChlAbo21869_0808.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR848038 Genomic DNA. Translation: CAH64190.1 .
    RefSeqi WP_011097308.1. NC_004552.2.
    YP_220140.1. NC_004552.2.

    3D structure databases

    ProteinModelPortali Q5L5A2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 218497.CAB743.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAH64190 ; CAH64190 ; CAB743 .
    GeneIDi 3337857.
    KEGGi cab:CAB743.
    PATRICi 20203015. VBIChlAbo21869_0808.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000034940.
    KOi K03439.
    OMAi IVELAMN.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci CABO218497:GJB0-766-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 27085 / S26/3.

    Entry informationi

    Entry nameiTRMB_CHLAB
    AccessioniPrimary (citable) accession number: Q5L5A2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: June 21, 2005
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3