Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Chlamydia abortus (strain DSM 27085 / S26/3) (Chlamydophila abortus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Nucleophile; for GATase activityUniRule annotation1
Active sitei604For Fru-6P isomerization activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:CAB756
OrganismiChlamydia abortus (strain DSM 27085 / S26/3) (Chlamydophila abortus)
Taxonomic identifieri218497 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000001012 Componenti: Chromosome

Subcellular locationi

Q5L589:
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation
ChainiPRO_00001353162 – 609Glutamine--fructose-6-phosphate aminotransferase [isomerizing]Add BLAST608

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi218497.CAB756.

Structurei

3D structure databases

ProteinModelPortaliQ5L589.
SMRiQ5L589.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 219Glutamine amidotransferase type-2UniRule annotationAdd BLAST218
Domaini280 – 426SIS 1UniRule annotationAdd BLAST147
Domaini458 – 599SIS 2UniRule annotationAdd BLAST142

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiENOG4105C46. Bacteria.
COG0449. LUCA.
HOGENOMiHOG000258896.
KOiK00820.
OMAiASEYRYA.
OrthoDBiPOG091H0061.

Family and domain databases

CDDicd05008. SIS_GlmS_GlmD_1. 1 hit.
cd05009. SIS_GlmS_GlmD_2. 1 hit.
Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS. 1 hit.
InterProiView protein in InterPro
IPR017932. GATase_2_dom.
IPR035466. GlmS/AgaS_SIS.
IPR035490. GlmS/FrlB_SIS.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiView protein in Pfam
PF01380. SIS. 2 hits.
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiView protein in PROSITE
PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5L589-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGIFGYLGS KLAIPVVLDG LAKLEYRGYD SAGLASIHLG DLFVRKTIGR
60 70 80 90 100
VDELRHSLEQ ENIQSLLAIG HTRWATHGVP TVSNAHPHVD ENRTCAVVHN
110 120 130 140 150
GIIENFKELK SFLLSEGVSF SSDTDSEVIA QLFAYRYQTT ADLIHSFSWT
160 170 180 190 200
LSQLQGSFSC GLIHKDHPDV LLCAAQESPL ILGLGEGENF IASDSRAFLK
210 220 230 240 250
HTQSIQALAS GELAIVGLGH EVETYNFALK RISKPVRQVT YTDAGSDKQG
260 270 280 290 300
YSYYMLKEIY EQPEVLERLV HKYLDPQGHI SEKFLQGFPL EDFDEISIVA
310 320 330 340 350
CGSSYHAGFL AKYIIESLVS IPVHVEVASE FRYRRAYIGQ KTLAILISQS
360 370 380 390 400
GETADTLAAL KEFRRRQVSC VLGICNVEES ALATGVDHCL FLEAGIEIGV
410 420 430 440 450
ASTKAFTAQL LLLILLGLKL TISKHTLSLT EHCACGKGLL ELPELCNRLL
460 470 480 490 500
ANENLHSWAH TYCNEDRFIF LGRRLMYPIC MEAALKLKEI AYVEANCYPA
510 520 530 540 550
GEMKHGPIAL ISKGSPVITF CGDSTVYEKM VGCIMEVKAR QAHVIAVASE
560 570 580 590 600
AQEDIAAVSD FQIYVPNSHS LASPILYTIV GQIMAYTMAL KKGNEIDCPR

NLAKSVTVE
Length:609
Mass (Da):67,057
Last modified:January 23, 2007 - v3
Checksum:iF2B2E9D59E614AC6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR848038 Genomic DNA. Translation: CAH64203.1.
RefSeqiWP_011097316.1. NC_004552.2.

Genome annotation databases

EnsemblBacteriaiCAH64203; CAH64203; CAB756.
KEGGicab:CAB756.

Similar proteinsi

Entry informationi

Entry nameiGLMS_CHLAB
AccessioniPrimary (citable) accession number: Q5L589
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 82 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome