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Q5L589

- GLMS_CHLAB

UniProt

Q5L589 - GLMS_CHLAB

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Protein
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
Gene
glmS, CAB756
Organism
Chlamydophila abortus (strain DSM 27085 / S26/3)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activity By similarity
Active sitei604 – 6041For Fru-6P isomerization activity By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciCABO218497:GJB0-779-MONOMER.

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene namesi
Name:glmS
Ordered Locus Names:CAB756
OrganismiChlamydophila abortus (strain DSM 27085 / S26/3)
Taxonomic identifieri218497 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydophila
ProteomesiUP000001012: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 609608Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation
PRO_0000135316Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi218497.CAB756.

Structurei

3D structure databases

ProteinModelPortaliQ5L589.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 219218Glutamine amidotransferase type-2
Add
BLAST
Domaini280 – 426147SIS 1
Add
BLAST
Domaini458 – 599142SIS 2
Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258896.
KOiK00820.
OMAiRIIICAC.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5L589-1 [UniParc]FASTAAdd to Basket

« Hide

MCGIFGYLGS KLAIPVVLDG LAKLEYRGYD SAGLASIHLG DLFVRKTIGR    50
VDELRHSLEQ ENIQSLLAIG HTRWATHGVP TVSNAHPHVD ENRTCAVVHN 100
GIIENFKELK SFLLSEGVSF SSDTDSEVIA QLFAYRYQTT ADLIHSFSWT 150
LSQLQGSFSC GLIHKDHPDV LLCAAQESPL ILGLGEGENF IASDSRAFLK 200
HTQSIQALAS GELAIVGLGH EVETYNFALK RISKPVRQVT YTDAGSDKQG 250
YSYYMLKEIY EQPEVLERLV HKYLDPQGHI SEKFLQGFPL EDFDEISIVA 300
CGSSYHAGFL AKYIIESLVS IPVHVEVASE FRYRRAYIGQ KTLAILISQS 350
GETADTLAAL KEFRRRQVSC VLGICNVEES ALATGVDHCL FLEAGIEIGV 400
ASTKAFTAQL LLLILLGLKL TISKHTLSLT EHCACGKGLL ELPELCNRLL 450
ANENLHSWAH TYCNEDRFIF LGRRLMYPIC MEAALKLKEI AYVEANCYPA 500
GEMKHGPIAL ISKGSPVITF CGDSTVYEKM VGCIMEVKAR QAHVIAVASE 550
AQEDIAAVSD FQIYVPNSHS LASPILYTIV GQIMAYTMAL KKGNEIDCPR 600
NLAKSVTVE 609
Length:609
Mass (Da):67,057
Last modified:January 23, 2007 - v3
Checksum:iF2B2E9D59E614AC6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR848038 Genomic DNA. Translation: CAH64203.1.
RefSeqiYP_220153.1. NC_004552.2.

Genome annotation databases

EnsemblBacteriaiCAH64203; CAH64203; CAB756.
GeneIDi3338059.
KEGGicab:CAB756.
PATRICi20203041. VBIChlAbo21869_0821.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR848038 Genomic DNA. Translation: CAH64203.1 .
RefSeqi YP_220153.1. NC_004552.2.

3D structure databases

ProteinModelPortali Q5L589.
ModBasei Search...

Protein-protein interaction databases

STRINGi 218497.CAB756.

Protein family/group databases

MEROPSi C44.971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAH64203 ; CAH64203 ; CAB756 .
GeneIDi 3338059.
KEGGi cab:CAB756.
PATRICi 20203041. VBIChlAbo21869_0821.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258896.
KOi K00820.
OMAi RIIICAC.
OrthoDBi EOG6KT2Q1.

Enzyme and pathway databases

BioCyci CABO218497:GJB0-779-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 27085 / S26/3.

Entry informationi

Entry nameiGLMS_CHLAB
AccessioniPrimary (citable) accession number: Q5L589
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 64 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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