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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Chlamydophila abortus (strain DSM 27085 / S26/3)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.By similarity

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciCABO218497:GJB0-782-MONOMER.
UniPathwayiUPA00359; UER00481.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:CAB759
OrganismiChlamydophila abortus (strain DSM 27085 / S26/3)
Taxonomic identifieri218497 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydophila
ProteomesiUP000001012 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 627627Lipid-A-disaccharide synthasePRO_0000255172Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi218497.CAB759.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 224224UnknownAdd
BLAST
Regioni225 – 627403Lipid-A-disaccharide synthaseAdd
BLAST

Sequence similaritiesi

In the C-terminal section; belongs to the LpxB family.Curated

Phylogenomic databases

eggNOGiCOG3952.
HOGENOMiHOG000034725.
KOiK00748.
OMAiKIIHYVC.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
IPR011499. Lipid_A_biosynth.
[Graphical view]
PfamiPF07578. LAB_N. 2 hits.
PF02684. LpxB. 1 hit.
[Graphical view]
ProDomiPD339292. LAB_N. 2 hits.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5L586-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFPLYLVRLL YPIGLIANLF FGFAFTLQWF LSERHKRACV PKAFWIFSSI
60 70 80 90 100
GAILMIAHGF IQSQFPIALL HGANLVIYFR NLNISSSRKL SLKTTLIILA
110 120 130 140 150
VTLLLTALPF ALEAYYHPNM QWMASPNIFH LPLPPPNMYW HMIGCLGLFT
160 170 180 190 200
FSCRFFIQWC HLEMNNQSTL PVLFWQVGFV GGFLAFLYFI RTGDPVNILS
210 220 230 240 250
YGCGLFPSIA NLRIIYKKSR LSEFHNPSYF ISAGEASGDT LGSDLLRHIK
260 270 280 290 300
ALHPDKRCFG VGGPLMRQEG LEPLIHMEEF QVSGFLEILT SIFTLIKKYR
310 320 330 340 350
KLYKAILKEN PEIVFCIDFP DFHFFLIKKL RKCGYTGKIV HYVCPSIWAW
360 370 380 390 400
RPKRKKILEK YLDTLLLILP FENELFINSP LKTIYLGHPL VKTISNFQHC
410 420 430 440 450
PSWKQALAIS DQPIVALFPG SRPGDILRNL QVHIRAFLAS SLAESHQLLV
460 470 480 490 500
SSYNLKHDQT ILDLLEKEGC CGKTVPAMYR YHLMRDCDCA LAKCGTIALE
510 520 530 540 550
AALNQTPTIV TCLLRPFDIF LAKYIFKIFM SAYSLPNIIT KSIIFPEFIG
560 570 580 590 600
GKSDFTPEEV AAAIDILANP KSREKQKRAC QTLLETMETN VVTVQECLQT
610 620
IHSLKSRFHT ENDCLGNYVQ KNVRPSF
Length:627
Mass (Da):71,610
Last modified:June 20, 2005 - v1
Checksum:iC9A28E903F7C80A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR848038 Genomic DNA. Translation: CAH64206.1.
RefSeqiWP_011097318.1. NC_004552.2.
YP_220156.1. NC_004552.2.

Genome annotation databases

EnsemblBacteriaiCAH64206; CAH64206; CAB759.
KEGGicab:CAB759.
PATRICi20203049. VBIChlAbo21869_0825.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR848038 Genomic DNA. Translation: CAH64206.1.
RefSeqiWP_011097318.1. NC_004552.2.
YP_220156.1. NC_004552.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi218497.CAB759.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAH64206; CAH64206; CAB759.
KEGGicab:CAB759.
PATRICi20203049. VBIChlAbo21869_0825.

Phylogenomic databases

eggNOGiCOG3952.
HOGENOMiHOG000034725.
KOiK00748.
OMAiKIIHYVC.
OrthoDBiEOG6FBWZR.

Enzyme and pathway databases

UniPathwayiUPA00359; UER00481.
BioCyciCABO218497:GJB0-782-MONOMER.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
IPR011499. Lipid_A_biosynth.
[Graphical view]
PfamiPF07578. LAB_N. 2 hits.
PF02684. LpxB. 1 hit.
[Graphical view]
ProDomiPD339292. LAB_N. 2 hits.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsiTIGR00215. lpxB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 27085 / S26/3.

Entry informationi

Entry nameiLPXB_CHLAB
AccessioniPrimary (citable) accession number: Q5L586
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 30, 2006
Last sequence update: June 20, 2005
Last modified: March 31, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.