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Q5L586

- LPXB_CHLAB

UniProt

Q5L586 - LPXB_CHLAB

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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Chlamydophila abortus (strain DSM 27085 / S26/3)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.By similarity

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciCABO218497:GJB0-782-MONOMER.
UniPathwayiUPA00359; UER00481.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:CAB759
OrganismiChlamydophila abortus (strain DSM 27085 / S26/3)
Taxonomic identifieri218497 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydophila
ProteomesiUP000001012: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 627627Lipid-A-disaccharide synthasePRO_0000255172Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi218497.CAB759.

Structurei

3D structure databases

ProteinModelPortaliQ5L586.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 224224UnknownAdd
BLAST
Regioni225 – 627403Lipid-A-disaccharide synthaseAdd
BLAST

Sequence similaritiesi

In the C-terminal section; belongs to the LpxB family.Curated

Phylogenomic databases

eggNOGiCOG3952.
HOGENOMiHOG000034725.
KOiK00748.
OMAiKIIHYVC.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
IPR011499. Lipid_A_biosynth.
[Graphical view]
PfamiPF07578. LAB_N. 2 hits.
PF02684. LpxB. 1 hit.
[Graphical view]
ProDomiPD339292. LAB_N. 2 hits.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5L586 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFPLYLVRLL YPIGLIANLF FGFAFTLQWF LSERHKRACV PKAFWIFSSI
60 70 80 90 100
GAILMIAHGF IQSQFPIALL HGANLVIYFR NLNISSSRKL SLKTTLIILA
110 120 130 140 150
VTLLLTALPF ALEAYYHPNM QWMASPNIFH LPLPPPNMYW HMIGCLGLFT
160 170 180 190 200
FSCRFFIQWC HLEMNNQSTL PVLFWQVGFV GGFLAFLYFI RTGDPVNILS
210 220 230 240 250
YGCGLFPSIA NLRIIYKKSR LSEFHNPSYF ISAGEASGDT LGSDLLRHIK
260 270 280 290 300
ALHPDKRCFG VGGPLMRQEG LEPLIHMEEF QVSGFLEILT SIFTLIKKYR
310 320 330 340 350
KLYKAILKEN PEIVFCIDFP DFHFFLIKKL RKCGYTGKIV HYVCPSIWAW
360 370 380 390 400
RPKRKKILEK YLDTLLLILP FENELFINSP LKTIYLGHPL VKTISNFQHC
410 420 430 440 450
PSWKQALAIS DQPIVALFPG SRPGDILRNL QVHIRAFLAS SLAESHQLLV
460 470 480 490 500
SSYNLKHDQT ILDLLEKEGC CGKTVPAMYR YHLMRDCDCA LAKCGTIALE
510 520 530 540 550
AALNQTPTIV TCLLRPFDIF LAKYIFKIFM SAYSLPNIIT KSIIFPEFIG
560 570 580 590 600
GKSDFTPEEV AAAIDILANP KSREKQKRAC QTLLETMETN VVTVQECLQT
610 620
IHSLKSRFHT ENDCLGNYVQ KNVRPSF
Length:627
Mass (Da):71,610
Last modified:June 21, 2005 - v1
Checksum:iC9A28E903F7C80A1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR848038 Genomic DNA. Translation: CAH64206.1.
RefSeqiWP_011097318.1. NC_004552.2.
YP_220156.1. NC_004552.2.

Genome annotation databases

EnsemblBacteriaiCAH64206; CAH64206; CAB759.
GeneIDi3337870.
KEGGicab:CAB759.
PATRICi20203049. VBIChlAbo21869_0825.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR848038 Genomic DNA. Translation: CAH64206.1 .
RefSeqi WP_011097318.1. NC_004552.2.
YP_220156.1. NC_004552.2.

3D structure databases

ProteinModelPortali Q5L586.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 218497.CAB759.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAH64206 ; CAH64206 ; CAB759 .
GeneIDi 3337870.
KEGGi cab:CAB759.
PATRICi 20203049. VBIChlAbo21869_0825.

Phylogenomic databases

eggNOGi COG3952.
HOGENOMi HOG000034725.
KOi K00748.
OMAi KIIHYVC.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci CABO218497:GJB0-782-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
IPR011499. Lipid_A_biosynth.
[Graphical view ]
Pfami PF07578. LAB_N. 2 hits.
PF02684. LpxB. 1 hit.
[Graphical view ]
ProDomi PD339292. LAB_N. 2 hits.
[Graphical view ] [Entries sharing at least one domain ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 27085 / S26/3.

Entry informationi

Entry nameiLPXB_CHLAB
AccessioniPrimary (citable) accession number: Q5L586
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 21, 2005
Last modified: October 29, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3