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Q5L586 (LPXB_CHLAB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lipid-A-disaccharide synthase

EC=2.4.1.182
Gene names
Name:lpxB
Ordered Locus Names:CAB759
OrganismChlamydophila abortus (strain DSM 27085 / S26/3) [Complete proteome] [HAMAP]
Taxonomic identifier218497 [NCBI]
Taxonomic lineageBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydophila

Protein attributes

Sequence length627 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00392

Catalytic activity

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP-Rule MF_00392

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP-Rule MF_00392

Sequence similarities

In the C-terminal section; belongs to the LpxB family.

Ontologies

Keywords
   Biological processLipid A biosynthesis
Lipid biosynthesis
Lipid metabolism
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processlipid A biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionlipid-A-disaccharide synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 627627Lipid-A-disaccharide synthase HAMAP-Rule MF_00392
PRO_0000255172

Regions

Region1 – 224224Unknown HAMAP-Rule MF_00392
Region225 – 627403Lipid-A-disaccharide synthase HAMAP-Rule MF_00392

Sequences

Sequence LengthMass (Da)Tools
Q5L586 [UniParc].

Last modified June 21, 2005. Version 1.
Checksum: C9A28E903F7C80A1

FASTA62771,610
        10         20         30         40         50         60 
MFPLYLVRLL YPIGLIANLF FGFAFTLQWF LSERHKRACV PKAFWIFSSI GAILMIAHGF 

        70         80         90        100        110        120 
IQSQFPIALL HGANLVIYFR NLNISSSRKL SLKTTLIILA VTLLLTALPF ALEAYYHPNM 

       130        140        150        160        170        180 
QWMASPNIFH LPLPPPNMYW HMIGCLGLFT FSCRFFIQWC HLEMNNQSTL PVLFWQVGFV 

       190        200        210        220        230        240 
GGFLAFLYFI RTGDPVNILS YGCGLFPSIA NLRIIYKKSR LSEFHNPSYF ISAGEASGDT 

       250        260        270        280        290        300 
LGSDLLRHIK ALHPDKRCFG VGGPLMRQEG LEPLIHMEEF QVSGFLEILT SIFTLIKKYR 

       310        320        330        340        350        360 
KLYKAILKEN PEIVFCIDFP DFHFFLIKKL RKCGYTGKIV HYVCPSIWAW RPKRKKILEK 

       370        380        390        400        410        420 
YLDTLLLILP FENELFINSP LKTIYLGHPL VKTISNFQHC PSWKQALAIS DQPIVALFPG 

       430        440        450        460        470        480 
SRPGDILRNL QVHIRAFLAS SLAESHQLLV SSYNLKHDQT ILDLLEKEGC CGKTVPAMYR 

       490        500        510        520        530        540 
YHLMRDCDCA LAKCGTIALE AALNQTPTIV TCLLRPFDIF LAKYIFKIFM SAYSLPNIIT 

       550        560        570        580        590        600 
KSIIFPEFIG GKSDFTPEEV AAAIDILANP KSREKQKRAC QTLLETMETN VVTVQECLQT 

       610        620 
IHSLKSRFHT ENDCLGNYVQ KNVRPSF 

« Hide

References

[1]"The Chlamydophila abortus genome sequence reveals an array of variable proteins that contribute to interspecies variation."
Thomson N.R., Yeats C., Bell K., Holden M.T.G., Bentley S.D., Livingstone M., Cerdeno-Tarraga A.-M., Harris B., Doggett J., Ormond D., Mungall K., Clarke K., Feltwell T., Hance Z., Sanders M., Quail M.A., Price C., Barrell B.G., Parkhill J., Longbottom D.
Genome Res. 15:629-640(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 27085 / S26/3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR848038 Genomic DNA. Translation: CAH64206.1.
RefSeqYP_220156.1. NC_004552.2.

3D structure databases

ProteinModelPortalQ5L586.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING218497.CAB759.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAH64206; CAH64206; CAB759.
GeneID3337870.
KEGGcab:CAB759.
PATRIC20203049. VBIChlAbo21869_0825.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3952.
HOGENOMHOG000034725.
KOK00748.
OMAKIIHYVC.
OrthoDBEOG6FBWZR.

Enzyme and pathway databases

BioCycCABO218497:GJB0-782-MONOMER.
UniPathwayUPA00359; UER00481.

Family and domain databases

HAMAPMF_00392. LpxB.
InterProIPR003835. Glyco_trans_19.
IPR011499. Lipid_A_biosynth.
[Graphical view]
PfamPF07578. LAB_N. 2 hits.
PF02684. LpxB. 1 hit.
[Graphical view]
ProDomPD339292. LAB_N. 2 hits.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR00215. lpxB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLPXB_CHLAB
AccessionPrimary (citable) accession number: Q5L586
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 21, 2005
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways