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Q5L586

- LPXB_CHLAB

UniProt

Q5L586 - LPXB_CHLAB

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Chlamydophila abortus (strain DSM 27085 / S26/3)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (21 Jun 2005)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.By similarity

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciCABO218497:GJB0-782-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthase (EC:2.4.1.182)
    Gene namesi
    Name:lpxB
    Ordered Locus Names:CAB759
    OrganismiChlamydophila abortus (strain DSM 27085 / S26/3)
    Taxonomic identifieri218497 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydophila
    ProteomesiUP000001012: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 627627Lipid-A-disaccharide synthasePRO_0000255172Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi218497.CAB759.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5L586.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 224224UnknownAdd
    BLAST
    Regioni225 – 627403Lipid-A-disaccharide synthaseAdd
    BLAST

    Sequence similaritiesi

    In the C-terminal section; belongs to the LpxB family.Curated

    Phylogenomic databases

    eggNOGiCOG3952.
    HOGENOMiHOG000034725.
    KOiK00748.
    OMAiKIIHYVC.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    IPR011499. Lipid_A_biosynth.
    [Graphical view]
    PfamiPF07578. LAB_N. 2 hits.
    PF02684. LpxB. 1 hit.
    [Graphical view]
    ProDomiPD339292. LAB_N. 2 hits.
    [Graphical view] [Entries sharing at least one domain]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5L586-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFPLYLVRLL YPIGLIANLF FGFAFTLQWF LSERHKRACV PKAFWIFSSI    50
    GAILMIAHGF IQSQFPIALL HGANLVIYFR NLNISSSRKL SLKTTLIILA 100
    VTLLLTALPF ALEAYYHPNM QWMASPNIFH LPLPPPNMYW HMIGCLGLFT 150
    FSCRFFIQWC HLEMNNQSTL PVLFWQVGFV GGFLAFLYFI RTGDPVNILS 200
    YGCGLFPSIA NLRIIYKKSR LSEFHNPSYF ISAGEASGDT LGSDLLRHIK 250
    ALHPDKRCFG VGGPLMRQEG LEPLIHMEEF QVSGFLEILT SIFTLIKKYR 300
    KLYKAILKEN PEIVFCIDFP DFHFFLIKKL RKCGYTGKIV HYVCPSIWAW 350
    RPKRKKILEK YLDTLLLILP FENELFINSP LKTIYLGHPL VKTISNFQHC 400
    PSWKQALAIS DQPIVALFPG SRPGDILRNL QVHIRAFLAS SLAESHQLLV 450
    SSYNLKHDQT ILDLLEKEGC CGKTVPAMYR YHLMRDCDCA LAKCGTIALE 500
    AALNQTPTIV TCLLRPFDIF LAKYIFKIFM SAYSLPNIIT KSIIFPEFIG 550
    GKSDFTPEEV AAAIDILANP KSREKQKRAC QTLLETMETN VVTVQECLQT 600
    IHSLKSRFHT ENDCLGNYVQ KNVRPSF 627
    Length:627
    Mass (Da):71,610
    Last modified:June 21, 2005 - v1
    Checksum:iC9A28E903F7C80A1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR848038 Genomic DNA. Translation: CAH64206.1.
    RefSeqiYP_220156.1. NC_004552.2.

    Genome annotation databases

    EnsemblBacteriaiCAH64206; CAH64206; CAB759.
    GeneIDi3337870.
    KEGGicab:CAB759.
    PATRICi20203049. VBIChlAbo21869_0825.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR848038 Genomic DNA. Translation: CAH64206.1 .
    RefSeqi YP_220156.1. NC_004552.2.

    3D structure databases

    ProteinModelPortali Q5L586.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 218497.CAB759.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAH64206 ; CAH64206 ; CAB759 .
    GeneIDi 3337870.
    KEGGi cab:CAB759.
    PATRICi 20203049. VBIChlAbo21869_0825.

    Phylogenomic databases

    eggNOGi COG3952.
    HOGENOMi HOG000034725.
    KOi K00748.
    OMAi KIIHYVC.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci CABO218497:GJB0-782-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    IPR011499. Lipid_A_biosynth.
    [Graphical view ]
    Pfami PF07578. LAB_N. 2 hits.
    PF02684. LpxB. 1 hit.
    [Graphical view ]
    ProDomi PD339292. LAB_N. 2 hits.
    [Graphical view ] [Entries sharing at least one domain ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 27085 / S26/3.

    Entry informationi

    Entry nameiLPXB_CHLAB
    AccessioniPrimary (citable) accession number: Q5L586
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: June 21, 2005
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3