Q5L586 (LPXB_CHLAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lipid-A-disaccharide synthase
EC=2.4.1.182

Gene names

Name:	lpxB
Ordered Locus Names:	CAB759

Organism

Chlamydophila abortus (strain S26/3) [Complete proteome] [HAMAP]

Taxonomic identifier

218497 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Chlamydiae/Verrucomicrobia group › Chlamydiae › Chlamydiia › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydophila › Chlamydophila abortus

Protein attributes

Sequence length	627 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00392
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP-Rule MF_00392
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP-Rule MF_00392
Sequence similarities	In the C-terminal section; belongs to the LpxB family.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid biosynthesis Lipid metabolism
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 627	627	Lipid-A-disaccharide synthase HAMAP-Rule MF_00392		PRO_0000255172
Regions
	Region	1 – 224	224	Unknown HAMAP-Rule MF_00392
	Region	225 – 627	403	Lipid-A-disaccharide synthase HAMAP-Rule MF_00392

Sequences

	Sequence		Length	Mass (Da)
	Q5L586 [UniParc]. Last modified June 21, 2005. Version 1. Checksum: C9A28E903F7C80A1	FASTA	627	71,610
	10 20 30 40 50 60 MFPLYLVRLL YPIGLIANLF FGFAFTLQWF LSERHKRACV PKAFWIFSSI GAILMIAHGF 70 80 90 100 110 120 IQSQFPIALL HGANLVIYFR NLNISSSRKL SLKTTLIILA VTLLLTALPF ALEAYYHPNM 130 140 150 160 170 180 QWMASPNIFH LPLPPPNMYW HMIGCLGLFT FSCRFFIQWC HLEMNNQSTL PVLFWQVGFV 190 200 210 220 230 240 GGFLAFLYFI RTGDPVNILS YGCGLFPSIA NLRIIYKKSR LSEFHNPSYF ISAGEASGDT 250 260 270 280 290 300 LGSDLLRHIK ALHPDKRCFG VGGPLMRQEG LEPLIHMEEF QVSGFLEILT SIFTLIKKYR 310 320 330 340 350 360 KLYKAILKEN PEIVFCIDFP DFHFFLIKKL RKCGYTGKIV HYVCPSIWAW RPKRKKILEK 370 380 390 400 410 420 YLDTLLLILP FENELFINSP LKTIYLGHPL VKTISNFQHC PSWKQALAIS DQPIVALFPG 430 440 450 460 470 480 SRPGDILRNL QVHIRAFLAS SLAESHQLLV SSYNLKHDQT ILDLLEKEGC CGKTVPAMYR 490 500 510 520 530 540 YHLMRDCDCA LAKCGTIALE AALNQTPTIV TCLLRPFDIF LAKYIFKIFM SAYSLPNIIT 550 560 570 580 590 600 KSIIFPEFIG GKSDFTPEEV AAAIDILANP KSREKQKRAC QTLLETMETN VVTVQECLQT 610 620 IHSLKSRFHT ENDCLGNYVQ KNVRPSF

References

[1]

"The Chlamydophila abortus genome sequence reveals an array of variable proteins that contribute to interspecies variation." Thomson N.R., Yeats C., Bell K., Holden M.T.G., Bentley S.D., Livingstone M., Cerdeno-Tarraga A.-M., Harris B., Doggett J., Ormond D., Mungall K., Clarke K., Feltwell T., Hance Z., Sanders M., Quail M.A., Price C., Barrell B.G., Parkhill J., Longbottom D. Genome Res. 15:629-640(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: S26/3.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR848038 Genomic DNA. Translation: CAH64206.1.
RefSeq	YP_220156.1. NC_004552.2.
3D structure databases
ProteinModelPortal	Q5L586.
ModBase	Search...
Protein-protein interaction databases
STRING	218497.CAB759.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAH64206; CAH64206; CAB759.
GeneID	3337870.
KEGG	cab:CAB759.
PATRIC	20203049. VBIChlAbo21869_0825.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3952.
HOGENOM	HOG000034725.
KO	K00748.
OMA	CALAKCG.
ProtClustDB	PRK01021.
Enzyme and pathway databases
BioCyc	CABO218497:GJB0-782-MONOMER.
UniPathway	UPA00359; UER00481.
Family and domain databases
HAMAP	MF_00392. LpxB. Fused.
InterPro	IPR003835. Glyco_trans_19. IPR011499. Lipid_A_biosynth. [Graphical view]
Pfam	PF07578. LAB_N. 2 hits. PF02684. LpxB. 1 hit. [Graphical view]
ProDom	PD339292. LAB_N. 2 hits. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00215. lpxB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LPXB_CHLAB

Accession

Primary (citable) accession number: Q5L586

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	June 21, 2005
Last modified:	May 1, 2013
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program