Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q5L510 (DCUP_CHLAB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uroporphyrinogen decarboxylase
Short name=UPD
Short name=URO-D
EC=4.1.1.37
Gene names
Name:hemE
Ordered Locus Names:CAB844
OrganismChlamydophila abortus [Complete proteome] [HAMAP]
Taxonomic identifier83555 [NCBI]
Taxonomic lineageBacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydophila

Protein attributes

Sequence length333 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP MF_00218

Catalytic activity

Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218

Subunit structure

Homodimer By similarity. HAMAP MF_00218

Subcellular location

Cytoplasm By similarity HAMAP MF_00218.

Sequence similarities

Belongs to the uroporphyrinogen decarboxylase family.

Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Cellular componentCytoplasm
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processporphyrin-containing compound biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionuroporphyrinogen decarboxylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 333333Uroporphyrinogen decarboxylase HAMAP MF_00218
PRO_1000023894

Regions

Region21 – 255Substrate binding By similarity

Sites

Binding site701Substrate By similarity
Binding site1391Substrate By similarity
Binding site1941Substrate By similarity
Binding site3091Substrate By similarity
Site701Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5L510 [UniParc].

Last modified June 21, 2005. Version 1.
Checksum: CAEECE06E91663CF

FASTA33337,315
        10         20         30         40         50         60 
MSKFYDVIKP KASRPPVWFL RQVGRYMPQY RELKGSQTLK DFFHNTEAIT EATLLGPSLL 

        70         80         90        100        110        120 
KVDAAILFAD ILSLLDGFNI SYDFAPGPQI SFSPKEELIF TNDPQDTFSY LLKAIKNLVK 

       130        140        150        160        170        180 
RLSVPLIAFA ASPFTMACYL LEGGASKDFP KTMAFLYQHP ERFDALLKQL AEATVIYLKE 

       190        200        210        220        230        240 
QIQAGASAIQ LFESSSLRLP SALFSRYVTR PNTQLITQLK NSVSSPISLF CRCFDENFID 

       250        260        270        280        290        300 
LYSTGADTLH PDYHVNLSQI YTAVTHPGSL QGNIDPALFL LPQDQFLNHL EKYLSVLKHQ 

       310        320        330 
PKYIFNSGHG ILPETPLENV QAAVLCLTSI STS

« Hide

References

[1]"The Chlamydophila abortus genome sequence reveals an array of variable proteins that contribute to interspecies variation."
Thomson N.R., Yeats C., Bell K., Holden M.T.G., Bentley S.D., Livingstone M., Cerdeno-Tarraga A.-M., Harris B., Doggett J., Ormond D., Mungall K., Clarke K., Feltwell T., Hance Z., Sanders M., Quail M.A., Price C., Barrell B.G., Parkhill J., Longbottom D.
Genome Res. 15:629-640(2005) [PubMed: 15837807] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: S26/3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR848038 Genomic DNA. Translation: CAH64285.1.
RefSeqYP_220232.1. NC_004552.2.

3D structure databases

HSSPHSSP built from PDB template 1R3S based on UniProtKB P06132.
ProteinModelPortalQ5L510.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3337873.
GenomeReviewsGene locus CAB844 in contig CR848038_GR.
KEGGcab:CAB844.
PATRIC20203235. VBIChlAbo21869_0916.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG628392.
OMAENISIQL.
PhylomeDBQ5L510.
ProtClustDBPRK00115.

Enzyme and pathway databases

BioCycCABO218497:CAB844-MONOMER.

Family and domain databases

HAMAPMF_00218. URO-D.
[Tree]
InterProIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
KOK01599.
PANTHERPTHR21091:SF2. HemE. 1 hit.
PfamPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsTIGR01464. HemE. 1 hit.
PROSITEPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDCUP_CHLAB
AccessionPrimary (citable) accession number: Q5L510
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 21, 2005
Last modified: January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents