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Q5L4X1

- PCKG_CHLAB

UniProt

Q5L4X1 - PCKG_CHLAB

Protein

Phosphoenolpyruvate carboxykinase [GTP]

Gene

pckG

Organism
Chlamydophila abortus (strain DSM 27085 / S26/3)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (21 Jun 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.UniRule annotation

    Catalytic activityi

    GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

    Cofactori

    Binds 1 manganese ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei76 – 761SubstrateUniRule annotation
    Binding sitei218 – 2181Substrate; via amide nitrogenUniRule annotation
    Metal bindingi225 – 2251ManganeseUniRule annotation
    Binding sitei225 – 2251SubstrateUniRule annotation
    Metal bindingi245 – 2451Manganese; via tele nitrogenUniRule annotation
    Binding sitei267 – 2671SubstrateUniRule annotation
    Active sitei269 – 2691UniRule annotation
    Metal bindingi292 – 2921ManganeseUniRule annotation
    Binding sitei383 – 3831GTPUniRule annotation
    Binding sitei414 – 4141GTPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi268 – 2736GTPUniRule annotation
    Nucleotide bindingi508 – 5114GTPUniRule annotation

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-HAMAP
    2. manganese ion binding Source: UniProtKB-HAMAP
    3. phosphoenolpyruvate carboxykinase (GTP) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Gluconeogenesis

    Keywords - Ligandi

    GTP-binding, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCABO218497:GJB0-906-MONOMER.
    UniPathwayiUPA00138.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation (EC:4.1.1.32UniRule annotation)
    Short name:
    PEP carboxykinaseUniRule annotation
    Short name:
    PEPCKUniRule annotation
    Gene namesi
    Name:pckGUniRule annotation
    Ordered Locus Names:CAB884
    OrganismiChlamydophila abortus (strain DSM 27085 / S26/3)
    Taxonomic identifieri218497 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydophila
    ProteomesiUP000001012: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 603603Phosphoenolpyruvate carboxykinase [GTP]PRO_0000103594Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi218497.CAB884.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5L4X1.
    SMRiQ5L4X1. Positions 11-600.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni381 – 3833Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1274.
    HOGENOMiHOG000191700.
    KOiK01596.
    OMAiKEVINHE.
    OrthoDBiEOG6MPWQS.

    Family and domain databases

    Gene3Di3.40.449.10. 1 hit.
    3.90.228.20. 2 hits.
    HAMAPiMF_00452. PEPCK_GTP.
    InterProiIPR018091. PEP_carboxykin_GTP_CS.
    IPR013035. PEP_carboxykinase_C.
    IPR008209. PEP_carboxykinase_GTP.
    IPR008210. PEP_carboxykinase_N.
    [Graphical view]
    PANTHERiPTHR11561. PTHR11561. 1 hit.
    PfamiPF00821. PEPCK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001348. PEP_carboxykinase_GTP. 1 hit.
    SUPFAMiSSF68923. SSF68923. 1 hit.
    PROSITEiPS00505. PEPCK_GTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5L4X1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSVWSEAIQ HKDLKQWIQE VAELVTPKDI RICNGSDSEY VEIYGLMQQS    50
    GVAIPLNRDV HPNCFLVRSS PEDVARVEQF TFICTKEQKD AGPTNNWRDP 100
    EEMRQELHGL FRGCMRGRTL YVVPFCMGPL NSPFSLIGVE ITDSPYVVCS 150
    MKIMTRMGEE VLKALGTSGS FHKCLHSVGV PLAPGEKDLA WPCNPQHMRI 200
    VHFQDDSSVM SFGSGYGGNA LLGKKCVALR LASYIARSQG WLAEHMLIIG 250
    VTNPEGQKKY FAASFPSACG KTNLAMLKPK IPGWKVECVG DDIAWIRPGP 300
    DGRLYAVNPE FGFFGVAPGT SATTNPNALA TCTSNSIFTN VALTPDGDVW 350
    WEGLTSQPPE GLIDWQGKPW KPGGAPAAHP NSRFTTPVQQ CPVLDPQWNS 400
    PEGVPIEAMI FGGRRSETIP LVYEALSWQH GVTIGASMSS ATTAASVGEQ 450
    GKLRHDPFAM LPFCGYNMAH YFDHWLSFAS NTSLKLPKIY GVNWFRKDKN 500
    GNFIWPGFSD NLRVLEWIFR RTNGEESIAK KTPIGYLPEE SALNLEGLNL 550
    STQALQDLLS VDVPGWLKEV ANVREYCKIF GSDLPQAITD ELFRIENELK 600
    IIK 603
    Length:603
    Mass (Da):66,780
    Last modified:June 21, 2005 - v1
    Checksum:iBF614C7F35CDC83F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR848038 Genomic DNA. Translation: CAH64324.1.
    RefSeqiYP_220271.1. NC_004552.2.

    Genome annotation databases

    EnsemblBacteriaiCAH64324; CAH64324; CAB884.
    GeneIDi3338031.
    KEGGicab:CAB884.
    PATRICi20203323. VBIChlAbo21869_0956.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR848038 Genomic DNA. Translation: CAH64324.1 .
    RefSeqi YP_220271.1. NC_004552.2.

    3D structure databases

    ProteinModelPortali Q5L4X1.
    SMRi Q5L4X1. Positions 11-600.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 218497.CAB884.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAH64324 ; CAH64324 ; CAB884 .
    GeneIDi 3338031.
    KEGGi cab:CAB884.
    PATRICi 20203323. VBIChlAbo21869_0956.

    Phylogenomic databases

    eggNOGi COG1274.
    HOGENOMi HOG000191700.
    KOi K01596.
    OMAi KEVINHE.
    OrthoDBi EOG6MPWQS.

    Enzyme and pathway databases

    UniPathwayi UPA00138 .
    BioCyci CABO218497:GJB0-906-MONOMER.

    Family and domain databases

    Gene3Di 3.40.449.10. 1 hit.
    3.90.228.20. 2 hits.
    HAMAPi MF_00452. PEPCK_GTP.
    InterProi IPR018091. PEP_carboxykin_GTP_CS.
    IPR013035. PEP_carboxykinase_C.
    IPR008209. PEP_carboxykinase_GTP.
    IPR008210. PEP_carboxykinase_N.
    [Graphical view ]
    PANTHERi PTHR11561. PTHR11561. 1 hit.
    Pfami PF00821. PEPCK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001348. PEP_carboxykinase_GTP. 1 hit.
    SUPFAMi SSF68923. SSF68923. 1 hit.
    PROSITEi PS00505. PEPCK_GTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 27085 / S26/3.

    Entry informationi

    Entry nameiPCKG_CHLAB
    AccessioniPrimary (citable) accession number: Q5L4X1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2005
    Last sequence update: June 21, 2005
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3