Reviewed, UniProtKB/Swiss-Prot Q5L4Q6 (NTPA_CHLAB)

Names and origin

Protein names

Recommended name:
    Nucleoside-triphosphatase
    EC=3.6.1.15
Alternative name(s):
    Nucleoside triphosphate phosphohydrolase
      Short name=NTPase

Gene names

Ordered Locus Names:

CAB952

Organism

Chlamydophila abortus [Complete proteome] [HAMAP]

Taxonomic identifier

83555 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydophila

Protein attributes

Sequence length	206 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions By similarity. HAMAP MF_01405
Catalytic activity	NTP + H2O = NDP + phosphate. HAMAP MF_01405
Cofactor	Divalent cations By similarity. HAMAP MF_01405
Subunit structure	Homodimer By similarity. HAMAP MF_01405
Sequence similarities	Belongs to the HAM1 NTPase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	nucleoside-triphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 206	206	Nucleoside-triphosphatase HAMAP MF_01405		PRO_1000068415

Sequences

	Sequence		Length	Mass (Da)
	Q5L4Q6-1 [UniParc]. Last modified June 21, 2005. Version 1. Checksum: 09668302EA989013	FASTA	206	23,144
	10 20 30 40 50 60 MKIVIASSHG YKIRETKTFL KQLGSFDIFS LTDFPNYYAP KEVGSLPEEN ALAKGLHAAR 70 80 90 100 110 120 ELNSWVIADD TMLMVPALNG LPGKLSATFA GEDACDKDHR KKLLQEMQSL ESIVDRSAYF 130 140 150 160 170 180 ECCIVLASPE GKFFKTRGIC EGYISHQEKG SSGFGYDSLF LKYDYKQTFA ELSEDIKNQV 190 200 SHRAKALQKL APYLQDLLEK QLVSRN

References

[1]

"The Chlamydophila abortus genome sequence reveals an array of variable proteins that contribute to interspecies variation." Thomson N.R., Yeats C., Bell K., Holden M.T.G., Bentley S.D., Livingstone M., Cerdeno-Tarraga A.-M., Harris B., Doggett J., Ormond D., Mungall K., Clarke K., Feltwell T., Hance Z., Sanders M., Quail M.A., Price C., Barrell B.G., Parkhill J., Longbottom D. Genome Res. 15:629-640(2005) [PubMed: 15837807] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: S26/3.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR848038 Genomic DNA. Translation: CAH64390.1.
RefSeq	YP_220336.1.
3D structure databases
HSSP	HSSP built from PDB template 1K7K based on UniProtKB P52061.
SMR	Q5L4Q6. Positions 1-196.
ModBase	Search...
Genome annotation databases
GeneID	3337949.
GenomeReviews	Gene locus CAB952 in contig CR848038_GR.
KEGG	cab:CAB952.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG697237.
OMA	ICEGYIS.
PhylomeDB	Q5L4Q6.
Enzyme and pathway databases
BioCyc	CABO218497:CAB952-MONOMER.
BRENDA	3.6.1.15. 292247.
Family and domain databases
HAMAP	MF_01405. Nucleoside_triphosp. [Tree]
InterPro	IPR002637. Ham1p-like. IPR020922. Nucleoside-triphosphatase. [Graphical view]
PANTHER	PTHR11067. Ham1p_like. 1 hit.
Pfam	PF01725. Ham1p_like. 1 hit. [Graphical view]
TIGRFAMs	TIGR00042. Ham1p_like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NTPA_CHLAB

Accession

Primary (citable) accession number: Q5L4Q6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	June 21, 2005
Last modified:	February 9, 2010
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)