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Protein

Protein-arginine kinase

Gene

mcsB

Organism
Geobacillus kaustophilus (strain HTA426)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the specific phosphorylation of arginine residues in a large number of proteins. Is part of the bacterial stress response system. Protein arginine phosphorylation has a physiologically important role and is involved in the regulation of many critical cellular processes, such as protein homeostasis, motility, competence, and stringent and stress responses, by regulating gene expression and protein activity.UniRule annotation

Catalytic activityi

ATP + a [protein]-L-arginine = ADP + a [protein]-N(omega)-phospho-L-arginine.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei92 – 921ATPUniRule annotation
Binding sitei126 – 1261ATPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi27 – 315ATPUniRule annotation
Nucleotide bindingi177 – 1815ATPUniRule annotation
Nucleotide bindingi208 – 2136ATPUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciGKAU235909:GJO7-101-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-arginine kinaseUniRule annotation (EC:2.7.14.1UniRule annotation)
Gene namesi
Name:mcsBUniRule annotation
Ordered Locus Names:GK0077
OrganismiGeobacillus kaustophilus (strain HTA426)
Taxonomic identifieri235909 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
Proteomesi
  • UP000001172 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 363363Protein-arginine kinasePRO_1000025874Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi235909.GK0077.

Structurei

3D structure databases

ProteinModelPortaliQ5L437.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 255232Phosphagen kinase C-terminalUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ATP:guanido phosphotransferase family.UniRule annotation
Contains 1 phosphagen kinase C-terminal domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG41066A3. Bacteria.
COG3869. LUCA.
HOGENOMiHOG000082112.
KOiK19405.
OMAiIIMQERV.
OrthoDBiEOG6NKR1D.

Family and domain databases

Gene3Di3.30.590.10. 1 hit.
HAMAPiMF_00602. Prot_Arg_kinase.
InterProiIPR023660. Arg_Kinase.
IPR000749. ATP-guanido_PTrfase.
IPR022415. ATP-guanido_PTrfase_AS.
IPR022414. ATP-guanido_PTrfase_cat.
IPR014746. Gln_synth/guanido_kin_cat_dom.
[Graphical view]
PANTHERiPTHR11547. PTHR11547. 2 hits.
PfamiPF00217. ATP-gua_Ptrans. 1 hit.
[Graphical view]
PROSITEiPS00112. PHOSPHAGEN_KINASE. 1 hit.
PS51510. PHOSPHAGEN_KINASE_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5L437-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFEKFFNTA VSAWMSQEGP DSDIVLSSRI RLARNIVDFR FPTLFSSEEA
60 70 80 90 100
MQIVALFERT FAHRSYGGAG RFELLKMSEL QPIEKRVLVE KHLISPHLAE
110 120 130 140 150
DSPFGACLLS ENEEISIMIN EEDHIRIQCL FPGLQLAEAL EAASELDDWI
160 170 180 190 200
EGYVNYAFDE RLGYLTSCPT NVGTGLRASV MMHLPALVLT QQINRIIPAI
210 220 230 240 250
NQLGLVVRGT YGEGSEALGN IFQISNQITL GKSEEDIVAD LHTIVQQLIA
260 270 280 290 300
QERAARQALV KTLGIQLEDK VFRSYGILAN CRVIESKEAA QCLSDVRLGI
310 320 330 340 350
DLGYIKNISR NILNELMILT QPGFLQQYAG GALRPEERDV RRAALIRERL
360
KMEERRKMEG DER
Length:363
Mass (Da):40,874
Last modified:February 1, 2005 - v1
Checksum:iC16FE5CA485E4B07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000043 Genomic DNA. Translation: BAD74362.1.
RefSeqiWP_011229592.1. NC_006510.1.

Genome annotation databases

EnsemblBacteriaiBAD74362; BAD74362; GK0077.
GeneIDi3186203.
KEGGigka:GK0077.
PATRICi21961213. VBIGeoKau81518_0130.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000043 Genomic DNA. Translation: BAD74362.1.
RefSeqiWP_011229592.1. NC_006510.1.

3D structure databases

ProteinModelPortaliQ5L437.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi235909.GK0077.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD74362; BAD74362; GK0077.
GeneIDi3186203.
KEGGigka:GK0077.
PATRICi21961213. VBIGeoKau81518_0130.

Phylogenomic databases

eggNOGiENOG41066A3. Bacteria.
COG3869. LUCA.
HOGENOMiHOG000082112.
KOiK19405.
OMAiIIMQERV.
OrthoDBiEOG6NKR1D.

Enzyme and pathway databases

BioCyciGKAU235909:GJO7-101-MONOMER.

Family and domain databases

Gene3Di3.30.590.10. 1 hit.
HAMAPiMF_00602. Prot_Arg_kinase.
InterProiIPR023660. Arg_Kinase.
IPR000749. ATP-guanido_PTrfase.
IPR022415. ATP-guanido_PTrfase_AS.
IPR022414. ATP-guanido_PTrfase_cat.
IPR014746. Gln_synth/guanido_kin_cat_dom.
[Graphical view]
PANTHERiPTHR11547. PTHR11547. 2 hits.
PfamiPF00217. ATP-gua_Ptrans. 1 hit.
[Graphical view]
PROSITEiPS00112. PHOSPHAGEN_KINASE. 1 hit.
PS51510. PHOSPHAGEN_KINASE_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Thermoadaptation trait revealed by the genome sequence of thermophilic Geobacillus kaustophilus."
    Takami H., Takaki Y., Chee G.-J., Nishi S., Shimamura S., Suzuki H., Matsui S., Uchiyama I.
    Nucleic Acids Res. 32:6292-6303(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HTA426.

Entry informationi

Entry nameiMCSB_GEOKA
AccessioniPrimary (citable) accession number: Q5L437
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 1, 2005
Last modified: November 11, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.