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Q5L3P0

- GLMS_GEOKA

UniProt

Q5L3P0 - GLMS_GEOKA

Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Geobacillus kaustophilus (strain HTA426)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

    Catalytic activityi

    L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
    Active sitei595 – 5951For Fru-6P isomerization activityUniRule annotation

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbohydrate biosynthetic process Source: InterPro
    2. glutamine metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Enzyme and pathway databases

    BioCyciGKAU235909:GJO7-189-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
    Alternative name(s):
    D-fructose-6-phosphate amidotransferaseUniRule annotation
    GFATUniRule annotation
    Glucosamine-6-phosphate synthaseUniRule annotation
    Hexosephosphate aminotransferaseUniRule annotation
    L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
    Gene namesi
    Name:glmSUniRule annotation
    Ordered Locus Names:GK0155
    OrganismiGeobacillus kaustophilus (strain HTA426)
    Taxonomic identifieri235909 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
    ProteomesiUP000001172: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedUniRule annotation
    Chaini2 – 600599Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135334Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi235909.GK0155.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5L3P0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 217216Glutamine amidotransferase type-2UniRule annotationAdd
    BLAST
    Domaini283 – 422140SIS 1UniRule annotationAdd
    BLAST
    Domaini452 – 590139SIS 2UniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
    Contains 2 SIS domains.UniRule annotation

    Keywords - Domaini

    Glutamine amidotransferase, Repeat

    Phylogenomic databases

    eggNOGiCOG0449.
    HOGENOMiHOG000258896.
    KOiK00820.
    OMAiPVTRRFM.
    OrthoDBiEOG6KT2Q1.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    HAMAPiMF_00164. GlmS.
    InterProiIPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view]
    PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
    PfamiPF01380. SIS. 2 hits.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    TIGRFAMsiTIGR01135. glmS. 1 hit.
    PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5L3P0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCGIVGYIGY QDVKEILLRG LEKLEYRGYD SAGIAVLNES GVHVFKEKGR    50
    IADLRRIVDP NVNATVGIGH TRWATHGAPS RVNAHPHQSA SGRFTLVHNG 100
    VIENYEMVKR DYLADVAFQS DTDTEVIVQL VEKFVRDGLT TEEAFRKTLS 150
    LLKGSYAIAM IDAQDENTIY AAKNKSPLLV GLGDGFNVVA SDAMAMLQVT 200
    NQFVELMDGE LVIVTSENVT IQTLNGETVK RKPFTAELDA SDIEKGTYPH 250
    YMLKEIDEQP FVIRRIIQKY QDDNGELAID KAIINEVLNA DRLYIVACGT 300
    SYHAGLVGKQ LIESWAKIPV EVHIASEFSY NMPLLSEKPL FIFISQSGET 350
    ADSRAVLVQT NKLGYKAITI TNVPGSTLSR EADYTLLLHA GPEIAVASTK 400
    AYTAQIAVLA ILAAAAAKAK GFELDFDLTK ELAIVANVME MLCDAKEEME 450
    KIASDYLTLT RNCFFIGRAV DYYVCLEGAL KLKEISYIQA EGFAGGELKH 500
    GTIALIEDGT PVIALATQEH VNLSIRGNVK EVVARGANPC VISMRGLEGD 550
    GDRFIIPAVH PDLTPLVSVV PLQLIAYYAA LHRGCDVDKP RNLAKSVTVE 600
    Length:600
    Mass (Da):65,643
    Last modified:January 23, 2007 - v3
    Checksum:i2D8E904BBC8C1C69
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000043 Genomic DNA. Translation: BAD74440.1.
    RefSeqiYP_146008.1. NC_006510.1.

    Genome annotation databases

    EnsemblBacteriaiBAD74440; BAD74440; GK0155.
    GeneIDi3184931.
    KEGGigka:GK0155.
    PATRICi21961393. VBIGeoKau81518_0210.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000043 Genomic DNA. Translation: BAD74440.1 .
    RefSeqi YP_146008.1. NC_006510.1.

    3D structure databases

    ProteinModelPortali Q5L3P0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 235909.GK0155.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD74440 ; BAD74440 ; GK0155 .
    GeneIDi 3184931.
    KEGGi gka:GK0155.
    PATRICi 21961393. VBIGeoKau81518_0210.

    Phylogenomic databases

    eggNOGi COG0449.
    HOGENOMi HOG000258896.
    KOi K00820.
    OMAi PVTRRFM.
    OrthoDBi EOG6KT2Q1.

    Enzyme and pathway databases

    BioCyci GKAU235909:GJO7-189-MONOMER.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    HAMAPi MF_00164. GlmS.
    InterProi IPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view ]
    PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
    Pfami PF01380. SIS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    TIGRFAMsi TIGR01135. glmS. 1 hit.
    PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Thermoadaptation trait revealed by the genome sequence of thermophilic Geobacillus kaustophilus."
      Takami H., Takaki Y., Chee G.-J., Nishi S., Shimamura S., Suzuki H., Matsui S., Uchiyama I.
      Nucleic Acids Res. 32:6292-6303(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HTA426.

    Entry informationi

    Entry nameiGLMS_GEOKA
    AccessioniPrimary (citable) accession number: Q5L3P0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2005
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 67 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3