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Q5L3K8 (ROCA_GEOKA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
1-pyrroline-5-carboxylate dehydrogenase
Short name=P5C dehydrogenase
EC=1.5.1.12
Gene names
Name:rocA
Ordered Locus Names:GK0187
OrganismGeobacillus kaustophilus (strain HTA426) [Complete proteome] [HAMAP]
Taxonomic identifier235909 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Geobacillus

Protein attributes

Sequence length515 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-1-pyrroline-5-carboxylate + NAD(P)+ + 2 H2O = L-glutamate + NAD(P)H. HAMAP MF_00733

Pathway

Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2. HAMAP MF_00733

Sequence similarities

Belongs to the aldehyde dehydrogenase family. RocA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 5155151-pyrroline-5-carboxylate dehydrogenase HAMAP MF_00733
PRO_1000045970

Sites

Active site2861 By similarity
Active site3201 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5L3K8 [UniParc].

Last modified February 1, 2005. Version 1.
Checksum: 9E3253E0D5EB852E

FASTA51556,667
        10         20         30         40         50         60 
MVQPYRHEPL TDFTVEANRE AFLAALKKVE SELGRDYPLV IGGERVMTED KIISINPANK 

        70         80         90        100        110        120 
TEVVGRVAKA NKELAERAMK TADEAFRTWS RTSPEARADI LFRAAAIVRR RKHEFSAWLV 

       130        140        150        160        170        180 
KEAGKPWREA DADTAEAIDF MEYYGRQMLK LKDGIPVESR PGETNRFFYI PLGVGVVISP 

       190        200        210        220        230        240 
WNFPFAIMAG TTVASLVTGN TVLLKPASAT PVVAYKFVEV LEEAGLPAGV LNYIPGSGAE 

       250        260        270        280        290        300 
VGDYLVDHPR TRFISFTGSR DVGIRIYERA AKVHPGQIWL KRVIAEMGGK DAIVVDKEAD 

       310        320        330        340        350        360 
LELAAQSIVA SAFGFSGQKC SACSRAIIVE DVYDQVLSRV VELTKQLNVG DPAEQATFMG 

       370        380        390        400        410        420 
PVIDQNAYNK IMEYIEIGKQ EGRLMTGGEG DDAKGFFIQP TVFADVDPNA RIMQEEIFGP 

       430        440        450        460        470        480 
VVAFAKARDF DHALEIANNT EYGLTGAVIS RNRANLEKAR HEFHVGNLYF NRGCTGAIVG 

       490        500        510 
YQPFGGFNMS GTDSKAGGPD YLILHMQAKT VSEMF

« Hide

References

[1]"Thermoadaptation trait revealed by the genome sequence of thermophilic Geobacillus kaustophilus."
Takami H., Takaki Y., Chee G.-J., Nishi S., Shimamura S., Suzuki H., Matsui S., Uchiyama I.
Nucleic Acids Res. 32:6292-6303(2004) [PubMed: 15576355] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HTA426.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000043 Genomic DNA. Translation: BAD74472.1.
RefSeqYP_146040.1. NC_006510.1.

3D structure databases

HSSPHSSP built from PDB template 2BJK based on UniProtKB Q5SI02.
ProteinModelPortalQ5L3K8.
SMRQ5L3K8. Positions 2-515.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3186084.
GenomeReviewsGene locus GK0187 in contig BA000043_GR.
KEGGgka:GK0187.
NMPDRfig|235909.3.peg.1485.
PATRIC21961457. VBIGeoKau81518_0242.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG752218.
OMATPYKHEP.
ProtClustDBPRK03137.

Enzyme and pathway databases

BioCycGKAU235909:GK0187-MONOMER.

Family and domain databases

HAMAPMF_00733. RocA.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR005932. Delta1-pyrroline-5-COlate_DH-2.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KOK00294.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR01237. D1pyr5carbox2. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameROCA_GEOKA
AccessionPrimary (citable) accession number: Q5L3K8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 1, 2005
Last modified: January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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