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Q5L3D0

- PUR5_GEOKA

UniProt

Q5L3D0 - PUR5_GEOKA

Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Geobacillus kaustophilus (strain HTA426)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Feb 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciGKAU235909:GJO7-316-MONOMER.
    UniPathwayiUPA00074; UER00129.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
    Alternative name(s):
    AIR synthaseUniRule annotation
    AIRSUniRule annotation
    Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
    Gene namesi
    Name:purMUniRule annotation
    Ordered Locus Names:GK0265
    OrganismiGeobacillus kaustophilus (strain HTA426)
    Taxonomic identifieri235909 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
    ProteomesiUP000001172: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 346346Phosphoribosylformylglycinamidine cyclo-ligasePRO_0000258356Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi235909.GK0265.

    Structurei

    Secondary structure

    1
    346
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi18 – 2912
    Helixi47 – 504
    Beta strandi53 – 6311
    Helixi67 – 748
    Helixi80 – 9314
    Turni94 – 963
    Beta strandi98 – 11013
    Helixi113 – 13018
    Beta strandi133 – 1364
    Beta strandi151 – 16212
    Helixi163 – 1653
    Beta strandi177 – 1826
    Beta strandi184 – 1863
    Helixi191 – 1999
    Helixi217 – 2226
    Helixi229 – 23810
    Beta strandi243 – 2464
    Helixi251 – 2599
    Beta strandi264 – 2696
    Helixi277 – 2859
    Helixi290 – 2967
    Beta strandi301 – 3077
    Helixi309 – 3113
    Helixi312 – 32110
    Beta strandi327 – 34115

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2Z01X-ray2.20A1-346[»]
    ProteinModelPortaliQ5L3D0.
    SMRiQ5L3D0. Positions 17-342.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ5L3D0.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AIR synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0150.
    HOGENOMiHOG000229091.
    KOiK01933.
    OMAiVIGKIEH.
    OrthoDBiEOG61CM1V.

    Family and domain databases

    Gene3Di3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPiMF_00741_B. AIRS_B.
    InterProiIPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view]
    PfamiPF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsiTIGR00878. purM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5L3D0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKAYKQAGV DIEAGYQAVA LMKEHVQKTM RPEVLGGIGG FGGLFDLSAL    50
    GYRQPVLISG TDGVGTKLKL AFLLDRHDTI GIDCVAMCVN DIIVQGAEPL 100
    FFLDYIACGK AVPEKIAAIV KGVADGCVEA GCALIGGETA EMPGMYDEDE 150
    YDLAGFAVGV AEKERLITGE TIQAGDALVG LPSSGLHSNG YSLVRRIVFE 200
    QAKLSLDEIY EPLDVPLGEE LLKPTRIYAK LLRSVRERFT IKGMAHITGG 250
    GLIENIPRML PPGIGARIQL GSWPILPIFD FLREKGSLEE EEMFSVFNMG 300
    IGLVLAVSPE TAAPLVEWLS ERGEPAYIIG EVAKGAGVSF AGGGRA 346
    Length:346
    Mass (Da):36,816
    Last modified:February 1, 2005 - v1
    Checksum:i65B292536EB228B9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000043 Genomic DNA. Translation: BAD74550.1.
    RefSeqiYP_146118.1. NC_006510.1.

    Genome annotation databases

    EnsemblBacteriaiBAD74550; BAD74550; GK0265.
    GeneIDi3183396.
    KEGGigka:GK0265.
    PATRICi21961674. VBIGeoKau81518_0333.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000043 Genomic DNA. Translation: BAD74550.1 .
    RefSeqi YP_146118.1. NC_006510.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2Z01 X-ray 2.20 A 1-346 [» ]
    ProteinModelPortali Q5L3D0.
    SMRi Q5L3D0. Positions 17-342.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 235909.GK0265.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD74550 ; BAD74550 ; GK0265 .
    GeneIDi 3183396.
    KEGGi gka:GK0265.
    PATRICi 21961674. VBIGeoKau81518_0333.

    Phylogenomic databases

    eggNOGi COG0150.
    HOGENOMi HOG000229091.
    KOi K01933.
    OMAi VIGKIEH.
    OrthoDBi EOG61CM1V.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00129 .
    BioCyci GKAU235909:GJO7-316-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q5L3D0.

    Family and domain databases

    Gene3Di 3.30.1330.10. 1 hit.
    3.90.650.10. 1 hit.
    HAMAPi MF_00741_B. AIRS_B.
    InterProi IPR010918. AIR_synth_C_dom.
    IPR000728. AIR_synth_N_dom.
    IPR004733. PurM_cligase.
    IPR016188. PurM_N-like.
    [Graphical view ]
    Pfami PF00586. AIRS. 1 hit.
    PF02769. AIRS_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55326. SSF55326. 1 hit.
    SSF56042. SSF56042. 1 hit.
    TIGRFAMsi TIGR00878. purM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Thermoadaptation trait revealed by the genome sequence of thermophilic Geobacillus kaustophilus."
      Takami H., Takaki Y., Chee G.-J., Nishi S., Shimamura S., Suzuki H., Matsui S., Uchiyama I.
      Nucleic Acids Res. 32:6292-6303(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HTA426.

    Entry informationi

    Entry nameiPUR5_GEOKA
    AccessioniPrimary (citable) accession number: Q5L3D0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3