Q5L2F6 (Q5L2F6_GEOKA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Protein ArsC 1 HAMAP MF_01624

Alternative name(s):
Arsenate reductase 1 HAMAP MF_01624
Arsenical pump modifier 1 HAMAP MF_01624
Low molecular weight protein-tyrosine-phosphatase 1 HAMAP MF_01624

Gene names

Name:	arsC1 HAMAP MF_01624
Ordered Locus Names:	GK0589

Organism

Geobacillus kaustophilus (strain HTA426) [Complete proteome] [HAMAP]

Taxonomic identifier

235909 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Geobacillus

Protein attributes

Sequence length	140 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Reduces arsenate [As(V)] to arsenite [As(III)] and dephosphorylates tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Could switch between different functions in different circumstances By similarity. HAMAP MF_01624
Catalytic activity	Arsenate + thioredoxin = arsenite + thioredoxin disulfide + H2O. HAMAP MF_01624 Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. HAMAP MF_01624
Subunit structure	Monomer By similarity. HAMAP MF_01624
Sequence similarities	Belongs to the low molecular weight phosphotyrosine protein phosphatase superfamily. ArsC family. HAMAP MF_01624

Ontologies

Keywords
Biological process	Arsenical resistance HAMAP MF_01624
Domain	Redox-active center HAMAP MF_01624
Molecular function	Hydrolase HAMAP MF_01624 SAAS SAAS023485 Oxidoreductase HAMAP MF_01624
PTM	Disulfide bond HAMAP MF_01624
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	response to arsenic-containing substance Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	arsenate reductase (thioredoxin) activity Inferred from electronic annotation. Source: HAMAP protein tyrosine phosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q5L2F6 [UniParc]. Last modified February 1, 2005. Version 1. Checksum: 153DB897E910D1FC	FASTA	140	15,573
	10 20 30 40 50 60 MKNKKIIYFL CTGNSCRSQM AEGWAKKYLG DEWEVYSAGI EAHGLNPNAV KVMKEVGIDI 70 80 90 100 110 120 SNQTSDIIDP EILNKADLVV TLCGHAADHC PVTPPNVKRV HWGFDDPAKA EGTEEEKLAV 130 140 FRRVRDEIGA RIKKFAETGE

References

[1]

"Thermoadaptation trait revealed by the genome sequence of thermophilic Geobacillus kaustophilus." Takami H., Takaki Y., Chee G.-J., Nishi S., Shimamura S., Suzuki H., Matsui S., Uchiyama I. Nucleic Acids Res. 32:6292-6303(2004) [PubMed: 15576355] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HTA426.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000043 Genomic DNA. Translation: BAD74874.1.
RefSeq	YP_146442.1. NC_006510.1.
3D structure databases
ProteinModelPortal	Q5L2F6.
SMR	Q5L2F6. Positions 5-140.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3183444.
GenomeReviews	Gene locus GK0589 in contig BA000043_GR.
KEGG	gka:GK0589.
NMPDR	fig|235909.3.peg.2260.
PATRIC	21962379. VBIGeoKau81518_0661.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG730979.
OMA	YSAGMEA.
ProtClustDB	PRK13530.
Family and domain databases
HAMAP	MF_01624. Arsenate_reduct. [Tree]
InterPro	IPR014064. Arsenate_reductase_ArsC. IPR023485. Ptyr_pPase_SF. IPR017867. Tyr_phospatase_low_mol_wt. [Graphical view]
KO	K03741.
PANTHER	PTHR11717. Low_mwt_PTPase. 1 hit.
Pfam	PF01451. LMWPc. 1 hit. [Graphical view]
SMART	SM00226. LMWPc. 1 hit. [Graphical view]
SUPFAM	SSF52788. Tyr_Pase_low_mol_wt. 1 hit.
TIGRFAMs	TIGR02691. ArsC_pI258_fam. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q5L2F6_GEOKA

Accession

Primary (citable) accession number: Q5L2F6

Entry history

Integrated into UniProtKB/TrEMBL:	February 1, 2005
Last sequence update:	February 1, 2005
Last modified:	January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)