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Protein

Ferrochelatase

Gene

hemH

Organism
Geobacillus kaustophilus (strain HTA426)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the ferrous insertion into protoporphyrin IX.UniRule annotation

Catalytic activityi

Protoheme + 2 H+ = protoporphyrin + Fe2+.UniRule annotation

Pathwayi: protoheme biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes protoheme from protoporphyrin-IX.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Ferrochelatase (hemH)
This subpathway is part of the pathway protoheme biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes protoheme from protoporphyrin-IX, the pathway protoheme biosynthesis and in Porphyrin-containing compound metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi183IronUniRule annotation1
Metal bindingi264IronUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Heme biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00252; UER00325.

Names & Taxonomyi

Protein namesi
Recommended name:
FerrochelataseUniRule annotation (EC:4.99.1.1UniRule annotation)
Alternative name(s):
Heme synthaseUniRule annotation
Protoheme ferro-lyaseUniRule annotation
Gene namesi
Name:hemHUniRule annotation
Ordered Locus Names:GK0662
OrganismiGeobacillus kaustophilus (strain HTA426)
Taxonomic identifieri235909 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
Proteomesi
  • UP000001172 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001751441 – 316FerrochelataseAdd BLAST316

Interactioni

Protein-protein interaction databases

STRINGi235909.GK0662.

Structurei

3D structure databases

ProteinModelPortaliQ5L283.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ferrochelatase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107TTW. Bacteria.
COG0276. LUCA.
HOGENOMiHOG000060729.
KOiK01772.
OMAiMHKDGIT.
OrthoDBiPOG091H041Q.

Family and domain databases

CDDicd00419. Ferrochelatase_C. 1 hit.
cd03411. Ferrochelatase_N. 1 hit.
HAMAPiMF_00323. Ferrochelatase. 1 hit.
InterProiIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
IPR033644. Ferrochelatase_C.
IPR033659. Ferrochelatase_N.
[Graphical view]
PANTHERiPTHR11108. PTHR11108. 1 hit.
PfamiPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00109. hemH. 1 hit.
PROSITEiPS00534. FERROCHELATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5L283-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKKTAGLLV MAYGTPYRED DIERYYTHIR HGRKPPQEQI EDLKARYRAI
60 70 80 90 100
GGLSPLAKIT EEQAKRLEER LNEVQDEVEF RMYLGLKHIE PFIEDAVERM
110 120 130 140 150
HDDGIKEAVG IVLAPHYSTF SIRSYNERAK AAAKKLGGPT IYTIDQWYDE
160 170 180 190 200
PKFLQYWAEQ VRAIFAAMPE RERERAVLIV SAHSLPEKII QAGDPYPTQL
210 220 230 240 250
EDTAKRIADQ AGVAHYAVGW QSAGQTPEPW LGPDVQDLTR QLYEERGYTS
260 270 280 290 300
FVYAPVGFVA DHLEVLYDND IECKQVTEEI GARYYRPEMP NTNPLFIDAL
310
ASVVLKRWAE EGDRHE
Length:316
Mass (Da):36,315
Last modified:February 1, 2005 - v1
Checksum:i7D43922471A096A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000043 Genomic DNA. Translation: BAD74947.1.
RefSeqiWP_011230165.1. NC_006510.1.

Genome annotation databases

EnsemblBacteriaiBAD74947; BAD74947; GK0662.
GeneIDi3183896.
KEGGigka:GK0662.
PATRICi21962535. VBIGeoKau81518_0739.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000043 Genomic DNA. Translation: BAD74947.1.
RefSeqiWP_011230165.1. NC_006510.1.

3D structure databases

ProteinModelPortaliQ5L283.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi235909.GK0662.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD74947; BAD74947; GK0662.
GeneIDi3183896.
KEGGigka:GK0662.
PATRICi21962535. VBIGeoKau81518_0739.

Phylogenomic databases

eggNOGiENOG4107TTW. Bacteria.
COG0276. LUCA.
HOGENOMiHOG000060729.
KOiK01772.
OMAiMHKDGIT.
OrthoDBiPOG091H041Q.

Enzyme and pathway databases

UniPathwayiUPA00252; UER00325.

Family and domain databases

CDDicd00419. Ferrochelatase_C. 1 hit.
cd03411. Ferrochelatase_N. 1 hit.
HAMAPiMF_00323. Ferrochelatase. 1 hit.
InterProiIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
IPR033644. Ferrochelatase_C.
IPR033659. Ferrochelatase_N.
[Graphical view]
PANTHERiPTHR11108. PTHR11108. 1 hit.
PfamiPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00109. hemH. 1 hit.
PROSITEiPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHEMH_GEOKA
AccessioniPrimary (citable) accession number: Q5L283
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: February 1, 2005
Last modified: November 2, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.