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Q5L1R5 (NADK1_GEOKA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NAD kinase 1

EC=2.7.1.23
Alternative name(s):
ATP-dependent NAD kinase 1
Gene names
Name:nadK1
Ordered Locus Names:GK0830
OrganismGeobacillus kaustophilus (strain HTA426) [Complete proteome] [HAMAP]
Taxonomic identifier235909 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus

Protein attributes

Sequence length271 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity. HAMAP-Rule MF_00361

Catalytic activity

ATP + NAD+ = ADP + NADP+. HAMAP-Rule MF_00361

Cofactor

Divalent metal ions By similarity. HAMAP-Rule MF_00361

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00361.

Sequence similarities

Belongs to the NAD kinase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
NAD
NADP
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processNAD metabolic process

Inferred from electronic annotation. Source: InterPro

NADP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

NAD+ kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 271271NAD kinase 1 HAMAP-Rule MF_00361
PRO_0000229637

Regions

Nucleotide binding52 – 532NAD By similarity
Nucleotide binding129 – 1302NAD By similarity

Sites

Active site521Proton acceptor By similarity
Binding site1551NAD By similarity
Binding site1571NAD By similarity
Binding site1921NAD; via carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5L1R5 [UniParc].

Last modified February 1, 2005. Version 1.
Checksum: 9E0FB427BC76662A

FASTA27130,517
        10         20         30         40         50         60 
MKRTDAPLVF AITSKGDDIS NALAQKMKTY LLDFDLRYDE EEPDLVISVG GDGTLLYAFH 

        70         80         90        100        110        120 
RYCHRLDKTA FVGVHTGHLG FYADWVPEEL EKLVIAIAKT PYQVVEYPLL EVTIRYLNGG 

       130        140        150        160        170        180 
SEAKYLALNE CTVKCVSGTL VMDVEIRGDL FERFRGDGLC ISTPTGSTAY NKALGGAILH 

       190        200        210        220        230        240 
PSLEAIQVTE MASINNRVFR TIGSPLVLPA HHTCLLKPVN HVDFQITIDH LSLLHKEVKS 

       250        260        270 
IQCRVADEKV RFARFRPFPF WRRVRDSFIA D 

« Hide

References

[1]"Thermoadaptation trait revealed by the genome sequence of thermophilic Geobacillus kaustophilus."
Takami H., Takaki Y., Chee G.-J., Nishi S., Shimamura S., Suzuki H., Matsui S., Uchiyama I.
Nucleic Acids Res. 32:6292-6303(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HTA426.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000043 Genomic DNA. Translation: BAD75115.1.
RefSeqYP_146683.1. NC_006510.1.

3D structure databases

ProteinModelPortalQ5L1R5.
SMRQ5L1R5. Positions 10-271.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING235909.GK0830.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAD75115; BAD75115; GK0830.
GeneID3183873.
KEGGgka:GK0830.
PATRIC21962886. VBIGeoKau81518_0914.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0061.
HOGENOMHOG000275803.
KOK00858.
OMAQWITIVP.
OrthoDBEOG6PZXDR.

Enzyme and pathway databases

BioCycGKAU235909:GJO7-904-MONOMER.

Family and domain databases

Gene3D2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPMF_00361. NAD_kinase.
InterProIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERPTHR20275. PTHR20275. 1 hit.
PfamPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMSSF111331. SSF111331. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADK1_GEOKA
AccessionPrimary (citable) accession number: Q5L1R5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: February 1, 2005
Last modified: July 9, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families