Reviewed, UniProtKB/Swiss-Prot Q5L1R5 (PPNK1_GEOKA)

Names and origin

Protein names

Recommended name:
    Probable inorganic polyphosphate/ATP-NAD kinase 1
      Short name=Poly(P)/ATP NAD kinase 1
    EC=2.7.1.23

Gene names

Name:	ppnK1
Ordered Locus Names:	GK0830

Organism

Geobacillus kaustophilus [Complete proteome] [HAMAP]

Taxonomic identifier

1462 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Geobacillus

Protein attributes

Sequence length	271 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus By similarity.
Catalytic activity	ATP + NAD+ = ADP + NADP+. HAMAP MF_00361
Cofactor	Divalent metal ions By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the NAD kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding NAD NADP Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW NAD+ kinase activity Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 271	271	Probable inorganic polyphosphate/ATP-NAD kinase 1 HAMAP MF_00361		PRO_0000229637

Sequences

	Sequence		Length	Mass (Da)
	Q5L1R5-1 [UniParc]. Last modified February 1, 2005. Version 1. Checksum: 9E0FB427BC76662A	FASTA	271	30,517
	10 20 30 40 50 60 MKRTDAPLVF AITSKGDDIS NALAQKMKTY LLDFDLRYDE EEPDLVISVG GDGTLLYAFH 70 80 90 100 110 120 RYCHRLDKTA FVGVHTGHLG FYADWVPEEL EKLVIAIAKT PYQVVEYPLL EVTIRYLNGG 130 140 150 160 170 180 SEAKYLALNE CTVKCVSGTL VMDVEIRGDL FERFRGDGLC ISTPTGSTAY NKALGGAILH 190 200 210 220 230 240 PSLEAIQVTE MASINNRVFR TIGSPLVLPA HHTCLLKPVN HVDFQITIDH LSLLHKEVKS 250 260 270 IQCRVADEKV RFARFRPFPF WRRVRDSFIA D

References

[1]

"Thermoadaptation trait revealed by the genome sequence of thermophilic Geobacillus kaustophilus." Takami H., Takaki Y., Chee G.-J., Nishi S., Shimamura S., Suzuki H., Matsui S., Uchiyama I. Nucleic Acids Res. 32:6292-6303(2004) [PubMed: 15576355] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HTA426.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000043 Genomic DNA. Translation: BAD75115.1.
RefSeq	YP_146683.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3183873.
GenomeReviews	Gene locus GK0830 in contig BA000043_GR.
KEGG	gka:GK0830.
NMPDR	fig|235909.3.peg.1520.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q5L1R5.
OMA	FPFWRRV.
Enzyme and pathway databases
BioCyc	GKAU235909:GK0830-MON.
BRENDA	2.7.1.23. 281547.
Family and domain databases
HAMAP	MF_00361. [Tree]
InterPro	IPR017438. ATP-NAD_kinase_PpnK-typ_a/b. IPR017437. ATP-NAD_kinase_PpnK-typ_all-b. IPR002504. ATP_NADK. [Graphical view]
Gene3D	G3DSA:2.60.200.30. ATP-NAD_kinase_PpnK-typ. 1 hit. G3DSA:3.40.50.10330. ATP-NAD_kinase_PpnK-typ_a/b. 1 hit.
PANTHER	PTHR20275. ATP_NADK. 1 hit.
Pfam	PF01513. NAD_kinase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PPNK1_GEOKA

Accession

Primary (citable) accession number: Q5L1R5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	February 1, 2005
Last modified:	November 3, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)