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Q5L172

- ODO1_GEOKA

UniProt

Q5L172 - ODO1_GEOKA

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Protein

2-oxoglutarate dehydrogenase E1 component

Gene

odhA

Organism
Geobacillus kaustophilus (strain HTA426)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).UniRule annotation

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.UniRule annotation

Cofactori

thiamine diphosphateUniRule annotation

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciGKAU235909:GJO7-1098-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 componentUniRule annotation (EC:1.2.4.2UniRule annotation)
Alternative name(s):
Alpha-ketoglutarate dehydrogenaseUniRule annotation
Gene namesi
Name:odhAUniRule annotation
Ordered Locus Names:GK1023
OrganismiGeobacillus kaustophilus (strain HTA426)
Taxonomic identifieri235909 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
ProteomesiUP000001172: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9509502-oxoglutarate dehydrogenase E1 componentPRO_0000162172Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi235909.GK1023.

Structurei

3D structure databases

ProteinModelPortaliQ5L172.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha-ketoglutarate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259588.
KOiK00164.
OMAiGHQNANL.
OrthoDBiEOG6V1M1F.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
HAMAPiMF_01169. SucA_OdhA.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5L172-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKQTNYAQP WSQFYGPNLG YVIEMYEQYL DDPNSIDPEL KQLFEQWGAP
60 70 80 90 100
VLEEPVSPAD DETAKTHQTF RLPETPTIFS KLVAAVKLAD SIRHYGHLVA
110 120 130 140 150
DTNPLVKKEK KLRRLELDEY DLTEEDLKRI PVAFLCPHAP AHVKNGWDAI
160 170 180 190 200
LHLRKIYTDK IAFEFSQVHN LEERNWLIQQ IESGAYYPSL ANKERVALLR
210 220 230 240 250
RLTEVEGFEK FIHRTYVGQK RFSIEGLDSM VPLLDELVRQ AIEHEIDAVN
260 270 280 290 300
IGMAHRGRLN VLAHVLGKPY EMIFAEFQHA ESKNFIPSEG SVAITYGWTG
310 320 330 340 350
DVKYHLGAAR RLRNQSAHTM RITLANNPSH LEVVNPVVLG YTRAAQEDRT
360 370 380 390 400
KPGVPVQNTD ASFAILIHGD AAFPGQGIVA ETLNLSQLRG YTTGGTIHII
410 420 430 440 450
ANNMIGFTTE SYDSRSTTYA SDMAKGFEVP IVHVNADDPE ACLAAACLAF
460 470 480 490 500
AYRQRFKKDF VIDLIGYRRF GHNEMDEPMA TNPTMYAIIN QHPTVRKLYA
510 520 530 540 550
QKLMEKGIIT EREVDEMEQE VAERLKIAYE RVPKNEDELD FIMDPPKPVV
560 570 580 590 600
DRLPEVKTSV AKDVLHRVNE ELLQFPDGFN VFNKLERILK RRSGVFAQNG
610 620 630 640 650
KVDWAHAEIL AFATILQDGV PIRLTGQDSQ RGTFAQRHLV LHDVKTGEEY
660 670 680 690 700
VPLHHISGAK ASFVVYNSPL TEAAVLGYEY GYNVYAPETL VLWEAQFGDF
710 720 730 740 750
ANMAQVMFDQ FISSGRAKWG QKSGLVMLLP HGYEGQGPEH SSGRVERFLQ
760 770 780 790 800
LAAENNWTVA NLSTAAQYFH ILRRQAALLT REEVRPLIIM TPKSLLRHPL
810 820 830 840 850
AASDAEVFVD GAFSPVLEQP GLGADAGKVE RIVFGTGKLM IDLAEQIGKM
860 870 880 890 900
ESLDWLHIVR IEELYPFPEE AVKDIIARYP NVKELVWVQE EPKNMGAWLY
910 920 930 940 950
MEPRLRALAP EGVDVSYIGR RRRASPAEGD PVVHRKEQER IIRCALTKHE
Length:950
Mass (Da):107,561
Last modified:February 1, 2005 - v1
Checksum:i0A9769B6BB8BC10F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000043 Genomic DNA. Translation: BAD75308.1.
RefSeqiWP_011230523.1. NC_006510.1.
YP_146876.1. NC_006510.1.

Genome annotation databases

EnsemblBacteriaiBAD75308; BAD75308; GK1023.
GeneIDi3184920.
KEGGigka:GK1023.
PATRICi21963297. VBIGeoKau81518_1118.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000043 Genomic DNA. Translation: BAD75308.1 .
RefSeqi WP_011230523.1. NC_006510.1.
YP_146876.1. NC_006510.1.

3D structure databases

ProteinModelPortali Q5L172.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 235909.GK1023.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD75308 ; BAD75308 ; GK1023 .
GeneIDi 3184920.
KEGGi gka:GK1023.
PATRICi 21963297. VBIGeoKau81518_1118.

Phylogenomic databases

eggNOGi COG0567.
HOGENOMi HOG000259588.
KOi K00164.
OMAi GHQNANL.
OrthoDBi EOG6V1M1F.

Enzyme and pathway databases

BioCyci GKAU235909:GJO7-1098-MONOMER.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
HAMAPi MF_01169. SucA_OdhA.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Thermoadaptation trait revealed by the genome sequence of thermophilic Geobacillus kaustophilus."
    Takami H., Takaki Y., Chee G.-J., Nishi S., Shimamura S., Suzuki H., Matsui S., Uchiyama I.
    Nucleic Acids Res. 32:6292-6303(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HTA426.

Entry informationi

Entry nameiODO1_GEOKA
AccessioniPrimary (citable) accession number: Q5L172
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: February 1, 2005
Last modified: November 26, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3