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Q5L172

- ODO1_GEOKA

UniProt

Q5L172 - ODO1_GEOKA

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Protein
2-oxoglutarate dehydrogenase E1 component
Gene
odhA, GK1023
Organism
Geobacillus kaustophilus (strain HTA426)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.UniRule annotation

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.UniRule annotation

Cofactori

Thiamine pyrophosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciGKAU235909:GJO7-1098-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 component (EC:1.2.4.2)
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene namesi
Name:odhA
Ordered Locus Names:GK1023
OrganismiGeobacillus kaustophilus (strain HTA426)
Taxonomic identifieri235909 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
ProteomesiUP000001172: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9509502-oxoglutarate dehydrogenase E1 componentUniRule annotation
PRO_0000162172Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi235909.GK1023.

Structurei

3D structure databases

ProteinModelPortaliQ5L172.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259588.
KOiK00164.
OMAiGHQNANL.
OrthoDBiEOG6V1M1F.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
HAMAPiMF_01169. SucA_OdhA.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5L172-1 [UniParc]FASTAAdd to Basket

« Hide

MAKQTNYAQP WSQFYGPNLG YVIEMYEQYL DDPNSIDPEL KQLFEQWGAP    50
VLEEPVSPAD DETAKTHQTF RLPETPTIFS KLVAAVKLAD SIRHYGHLVA 100
DTNPLVKKEK KLRRLELDEY DLTEEDLKRI PVAFLCPHAP AHVKNGWDAI 150
LHLRKIYTDK IAFEFSQVHN LEERNWLIQQ IESGAYYPSL ANKERVALLR 200
RLTEVEGFEK FIHRTYVGQK RFSIEGLDSM VPLLDELVRQ AIEHEIDAVN 250
IGMAHRGRLN VLAHVLGKPY EMIFAEFQHA ESKNFIPSEG SVAITYGWTG 300
DVKYHLGAAR RLRNQSAHTM RITLANNPSH LEVVNPVVLG YTRAAQEDRT 350
KPGVPVQNTD ASFAILIHGD AAFPGQGIVA ETLNLSQLRG YTTGGTIHII 400
ANNMIGFTTE SYDSRSTTYA SDMAKGFEVP IVHVNADDPE ACLAAACLAF 450
AYRQRFKKDF VIDLIGYRRF GHNEMDEPMA TNPTMYAIIN QHPTVRKLYA 500
QKLMEKGIIT EREVDEMEQE VAERLKIAYE RVPKNEDELD FIMDPPKPVV 550
DRLPEVKTSV AKDVLHRVNE ELLQFPDGFN VFNKLERILK RRSGVFAQNG 600
KVDWAHAEIL AFATILQDGV PIRLTGQDSQ RGTFAQRHLV LHDVKTGEEY 650
VPLHHISGAK ASFVVYNSPL TEAAVLGYEY GYNVYAPETL VLWEAQFGDF 700
ANMAQVMFDQ FISSGRAKWG QKSGLVMLLP HGYEGQGPEH SSGRVERFLQ 750
LAAENNWTVA NLSTAAQYFH ILRRQAALLT REEVRPLIIM TPKSLLRHPL 800
AASDAEVFVD GAFSPVLEQP GLGADAGKVE RIVFGTGKLM IDLAEQIGKM 850
ESLDWLHIVR IEELYPFPEE AVKDIIARYP NVKELVWVQE EPKNMGAWLY 900
MEPRLRALAP EGVDVSYIGR RRRASPAEGD PVVHRKEQER IIRCALTKHE 950
Length:950
Mass (Da):107,561
Last modified:February 1, 2005 - v1
Checksum:i0A9769B6BB8BC10F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000043 Genomic DNA. Translation: BAD75308.1.
RefSeqiWP_011230523.1. NC_006510.1.
YP_146876.1. NC_006510.1.

Genome annotation databases

EnsemblBacteriaiBAD75308; BAD75308; GK1023.
GeneIDi3184920.
KEGGigka:GK1023.
PATRICi21963297. VBIGeoKau81518_1118.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000043 Genomic DNA. Translation: BAD75308.1 .
RefSeqi WP_011230523.1. NC_006510.1.
YP_146876.1. NC_006510.1.

3D structure databases

ProteinModelPortali Q5L172.
ModBasei Search...

Protein-protein interaction databases

STRINGi 235909.GK1023.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD75308 ; BAD75308 ; GK1023 .
GeneIDi 3184920.
KEGGi gka:GK1023.
PATRICi 21963297. VBIGeoKau81518_1118.

Phylogenomic databases

eggNOGi COG0567.
HOGENOMi HOG000259588.
KOi K00164.
OMAi GHQNANL.
OrthoDBi EOG6V1M1F.

Enzyme and pathway databases

BioCyci GKAU235909:GJO7-1098-MONOMER.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
HAMAPi MF_01169. SucA_OdhA.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Thermoadaptation trait revealed by the genome sequence of thermophilic Geobacillus kaustophilus."
    Takami H., Takaki Y., Chee G.-J., Nishi S., Shimamura S., Suzuki H., Matsui S., Uchiyama I.
    Nucleic Acids Res. 32:6292-6303(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HTA426.

Entry informationi

Entry nameiODO1_GEOKA
AccessioniPrimary (citable) accession number: Q5L172
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: February 1, 2005
Last modified: September 3, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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