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Q5L172 (ODO1_GEOKA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
2-oxoglutarate dehydrogenase E1 component

EC=1.2.4.2
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene names
Name:odhA
Ordered Locus Names:GK1023
OrganismGeobacillus kaustophilus (strain HTA426) [Complete proteome] [HAMAP]
Taxonomic identifier235909 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus

Protein attributes

Sequence length950 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity. HAMAP-Rule MF_01169

Catalytic activity

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2. HAMAP-Rule MF_01169

Cofactor

Thiamine pyrophosphate By similarity. HAMAP-Rule MF_01169

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01169

Sequence similarities

Belongs to the alpha-ketoglutarate dehydrogenase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 9509502-oxoglutarate dehydrogenase E1 component HAMAP-Rule MF_01169
PRO_0000162172

Sequences

Sequence LengthMass (Da)Tools
Q5L172 [UniParc].

Last modified February 1, 2005. Version 1.
Checksum: 0A9769B6BB8BC10F

FASTA950107,561
        10         20         30         40         50         60 
MAKQTNYAQP WSQFYGPNLG YVIEMYEQYL DDPNSIDPEL KQLFEQWGAP VLEEPVSPAD 

        70         80         90        100        110        120 
DETAKTHQTF RLPETPTIFS KLVAAVKLAD SIRHYGHLVA DTNPLVKKEK KLRRLELDEY 

       130        140        150        160        170        180 
DLTEEDLKRI PVAFLCPHAP AHVKNGWDAI LHLRKIYTDK IAFEFSQVHN LEERNWLIQQ 

       190        200        210        220        230        240 
IESGAYYPSL ANKERVALLR RLTEVEGFEK FIHRTYVGQK RFSIEGLDSM VPLLDELVRQ 

       250        260        270        280        290        300 
AIEHEIDAVN IGMAHRGRLN VLAHVLGKPY EMIFAEFQHA ESKNFIPSEG SVAITYGWTG 

       310        320        330        340        350        360 
DVKYHLGAAR RLRNQSAHTM RITLANNPSH LEVVNPVVLG YTRAAQEDRT KPGVPVQNTD 

       370        380        390        400        410        420 
ASFAILIHGD AAFPGQGIVA ETLNLSQLRG YTTGGTIHII ANNMIGFTTE SYDSRSTTYA 

       430        440        450        460        470        480 
SDMAKGFEVP IVHVNADDPE ACLAAACLAF AYRQRFKKDF VIDLIGYRRF GHNEMDEPMA 

       490        500        510        520        530        540 
TNPTMYAIIN QHPTVRKLYA QKLMEKGIIT EREVDEMEQE VAERLKIAYE RVPKNEDELD 

       550        560        570        580        590        600 
FIMDPPKPVV DRLPEVKTSV AKDVLHRVNE ELLQFPDGFN VFNKLERILK RRSGVFAQNG 

       610        620        630        640        650        660 
KVDWAHAEIL AFATILQDGV PIRLTGQDSQ RGTFAQRHLV LHDVKTGEEY VPLHHISGAK 

       670        680        690        700        710        720 
ASFVVYNSPL TEAAVLGYEY GYNVYAPETL VLWEAQFGDF ANMAQVMFDQ FISSGRAKWG 

       730        740        750        760        770        780 
QKSGLVMLLP HGYEGQGPEH SSGRVERFLQ LAAENNWTVA NLSTAAQYFH ILRRQAALLT 

       790        800        810        820        830        840 
REEVRPLIIM TPKSLLRHPL AASDAEVFVD GAFSPVLEQP GLGADAGKVE RIVFGTGKLM 

       850        860        870        880        890        900 
IDLAEQIGKM ESLDWLHIVR IEELYPFPEE AVKDIIARYP NVKELVWVQE EPKNMGAWLY 

       910        920        930        940        950 
MEPRLRALAP EGVDVSYIGR RRRASPAEGD PVVHRKEQER IIRCALTKHE 

« Hide

References

[1]"Thermoadaptation trait revealed by the genome sequence of thermophilic Geobacillus kaustophilus."
Takami H., Takaki Y., Chee G.-J., Nishi S., Shimamura S., Suzuki H., Matsui S., Uchiyama I.
Nucleic Acids Res. 32:6292-6303(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HTA426.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000043 Genomic DNA. Translation: BAD75308.1.
RefSeqYP_146876.1. NC_006510.1.

3D structure databases

ProteinModelPortalQ5L172.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING235909.GK1023.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAD75308; BAD75308; GK1023.
GeneID3184920.
KEGGgka:GK1023.
PATRIC21963297. VBIGeoKau81518_1118.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0567.
HOGENOMHOG000259588.
KOK00164.
OMAGHQNANL.
OrthoDBEOG6V1M1F.

Enzyme and pathway databases

BioCycGKAU235909:GJO7-1098-MONOMER.

Family and domain databases

Gene3D3.40.50.970. 2 hits.
HAMAPMF_01169. SucA_OdhA.
InterProIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERPTHR23152. PTHR23152. 1 hit.
PfamPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMSSF52518. SSF52518. 2 hits.
TIGRFAMsTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetSearch...

Entry information

Entry nameODO1_GEOKA
AccessionPrimary (citable) accession number: Q5L172
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: February 1, 2005
Last modified: June 11, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families