Q5L081 (MSCL_GEOKA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Large-conductance mechanosensitive channel

Gene names

Name:	mscL
Ordered Locus Names:	GK1370

Organism

Geobacillus kaustophilus (strain HTA426) [Complete proteome] [HAMAP]

Taxonomic identifier

235909 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Geobacillus

Protein attributes

Sequence length	131 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell By similarity. HAMAP MF_00115
Subunit structure	Homopentamer By similarity. HAMAP MF_00115
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_00115.
Sequence similarities	Belongs to the MscL family.

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Ionic channel
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ion channel activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 131	131	Large-conductance mechanosensitive channel HAMAP MF_00115		PRO_0000238001
Regions
	Transmembrane	8 – 28	21	Helical; Potential
	Transmembrane	30 – 50	21	Helical; Potential
	Transmembrane	67 – 87	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5L081 [UniParc]. Last modified February 1, 2005. Version 1. Checksum: B271529BB708A2BB	FASTA	131	14,735
	10 20 30 40 50 60 MWNEFKKFAI RGNVIDLAVG VIIGGAFGKI VSSLVNDIIM PLVGLILGGI NFSDLSWKVG 70 80 90 100 110 120 KAEVKYGAFI QTVVDFLIIA FSIFLFVKLI NTLYERVKKQ EEVKETAPTL TKEEELLTEI 130 RDLLKQQRET T

References

[1]

"Thermoadaptation trait revealed by the genome sequence of thermophilic Geobacillus kaustophilus." Takami H., Takaki Y., Chee G.-J., Nishi S., Shimamura S., Suzuki H., Matsui S., Uchiyama I. Nucleic Acids Res. 32:6292-6303(2004) [PubMed: 15576355] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HTA426.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000043 Genomic DNA. Translation: BAD75655.1.
RefSeq	YP_147223.1. NC_006510.1.
3D structure databases
ProteinModelPortal	Q5L081.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3183970.
GenomeReviews	Gene locus GK1370 in contig BA000043_GR.
KEGG	gka:GK1370.
NMPDR	fig|235909.3.peg.219.
PATRIC	21964025. VBIGeoKau81518_1481.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG727604.
OMA	VIDFVIV.
ProtClustDB	PRK13953.
Enzyme and pathway databases
BioCyc	GKAU235909:GK1370-MONOMER.
Family and domain databases
HAMAP	MF_00115. MscL. [Tree]
InterPro	IPR019823. Mechanosensitive_channel_CS. IPR001185. MS_channel. [Graphical view]
KO	K03282.
Pfam	PF01741. MscL. 1 hit. [Graphical view]
PRINTS	PR01264. MECHCHANNEL.
SUPFAM	SSF81330. MS_channel. 1 hit.
TIGRFAMs	TIGR00220. MscL. 1 hit.
PROSITE	PS01327. MSCL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MSCL_GEOKA

Accession

Primary (citable) accession number: Q5L081

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	February 1, 2005
Last modified:	January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program