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Protein

Probable malate:quinone oxidoreductase

Gene

mqo

Organism
Geobacillus kaustophilus (strain HTA426)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-malate + a quinone = oxaloacetate + reduced quinone.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable malate:quinone oxidoreductase (mqo)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciGKAU235909:GJO7-1472-MONOMER.
UniPathwayiUPA00223; UER01008.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable malate:quinone oxidoreductaseUniRule annotation (EC:1.1.5.4UniRule annotation)
Alternative name(s):
MQOUniRule annotation
Malate dehydrogenase [quinone]UniRule annotation
Gene namesi
Name:mqoUniRule annotation
Ordered Locus Names:GK1396
OrganismiGeobacillus kaustophilus (strain HTA426)
Taxonomic identifieri235909 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
Proteomesi
  • UP000001172 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 501501Probable malate:quinone oxidoreductasePRO_1000023801Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi235909.GK1396.

Structurei

3D structure databases

ProteinModelPortaliQ5L055.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MQO family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DWT. Bacteria.
COG0579. LUCA.
HOGENOMiHOG000109379.
KOiK00116.
OMAiEPIAATK.
OrthoDBiEOG6X6R8Z.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
HAMAPiMF_00212. MQO.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR006231. MQO.
[Graphical view]
PfamiPF06039. Mqo. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR01320. mal_quin_oxido. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5L055-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNKQGKMDV ILIGAGIMSA TLGTLLKELA PEWDIVVFER LEEAGAESSN
60 70 80 90 100
EWNNAGTGHA ALCELNYTVE KADGSIDIGK AIKINEQFYV SLQFWAYLVN
110 120 130 140 150
SGILRDPKDF VRPLPHMSFV QGEDNVAFLK KRHETMAANP LFKGMEFTDD
160 170 180 190 200
PKKLAEWVPL MMEGRVVDEP IAATRIESGT DVNFGALTRQ LFEHLKRKNV
210 220 230 240 250
EIRYRHHVED IKRTSDGLWE LKVRNLDTGT VELHAAKFVF IGAGGGSLHL
260 270 280 290 300
LQKSGIPEGK GIGGFPVSGL FMVCNNPEVV EQHHAKVYGK AKVGAPPMSV
310 320 330 340 350
PHLDTRFIDN QKMLLFGPFA GFSPKFLKNG SMLDLFTSIK PHNVLTILAA
360 370 380 390 400
GVKNMSLTNY LIQQVLLSKE QRMQELREFV PTAKSDEWDI VVAGQRVQVI
410 420 430 440 450
KDTESGGKGT LQFGTEVVHA ADGSIAALLG ASPGASTAVH VMLEVMEKCF
460 470 480 490 500
PERMNEWRAK VKEMIPSYGE SLMKNEALLR QVQASTAEAL GLNGHFAMQL

A
Length:501
Mass (Da):55,200
Last modified:February 1, 2005 - v1
Checksum:iC58460F1D2AC4831
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000043 Genomic DNA. Translation: BAD75681.1.
RefSeqiWP_011230892.1. NC_006510.1.

Genome annotation databases

EnsemblBacteriaiBAD75681; BAD75681; GK1396.
GeneIDi3183755.
KEGGigka:GK1396.
PATRICi21964081. VBIGeoKau81518_1508.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000043 Genomic DNA. Translation: BAD75681.1.
RefSeqiWP_011230892.1. NC_006510.1.

3D structure databases

ProteinModelPortaliQ5L055.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi235909.GK1396.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD75681; BAD75681; GK1396.
GeneIDi3183755.
KEGGigka:GK1396.
PATRICi21964081. VBIGeoKau81518_1508.

Phylogenomic databases

eggNOGiENOG4105DWT. Bacteria.
COG0579. LUCA.
HOGENOMiHOG000109379.
KOiK00116.
OMAiEPIAATK.
OrthoDBiEOG6X6R8Z.

Enzyme and pathway databases

UniPathwayiUPA00223; UER01008.
BioCyciGKAU235909:GJO7-1472-MONOMER.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
HAMAPiMF_00212. MQO.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR006231. MQO.
[Graphical view]
PfamiPF06039. Mqo. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR01320. mal_quin_oxido. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Thermoadaptation trait revealed by the genome sequence of thermophilic Geobacillus kaustophilus."
    Takami H., Takaki Y., Chee G.-J., Nishi S., Shimamura S., Suzuki H., Matsui S., Uchiyama I.
    Nucleic Acids Res. 32:6292-6303(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HTA426.

Entry informationi

Entry nameiMQO_GEOKA
AccessioniPrimary (citable) accession number: Q5L055
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 1, 2005
Last modified: November 11, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.