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Protein

Catalase-peroxidase

Gene

katG

Organism
Geobacillus kaustophilus (strain HTA426)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei97Transition state stabilizerUniRule annotation1
Active sitei101Proton acceptorUniRule annotation1
Metal bindingi264Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Protein family/group databases

PeroxiBasei2370. GkaCP01_HTA426.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:GK1710
OrganismiGeobacillus kaustophilus (strain HTA426)
Taxonomic identifieri235909 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
Proteomesi
  • UP000001172 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003547991 – 736Catalase-peroxidaseAdd BLAST736

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki100 ↔ 223Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-249)UniRule annotation
Cross-linki223 ↔ 249Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-100)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi235909.GK1710.

Structurei

3D structure databases

ProteinModelPortaliQ5KZ91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5KZ91-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNQNQHNTS KCPYHGSVTS YNSNRTTNKD WWPNQLNLSI LHQHDRKTNP
60 70 80 90 100
HDEEFNYAEE FQKLDYWALK EDLRKLMTES QDWWPADYGH YGPLFIRMAW
110 120 130 140 150
HSAGTYRIGD GRGGGSTGTQ RFAPLNSWPD NANLDKARRL LWPIKKKYGN
160 170 180 190 200
KISWADLMIL AGNVAIESMG GKTIGFGGGR EDVWHPEEDI YWGAEKEWLA
210 220 230 240 250
SERYSGDREL ENPLAAVQMG LIYVNPEGPD GKPDPVAAAR DIRETFRRMG
260 270 280 290 300
MNDEETVALI AGGHTFGKAH GAGPASHVGP EPEAAPIEAQ GLGWISSYGK
310 320 330 340 350
GKGRDTITSG IEGAWTPTPT QWDNSYFRLL FEYEWKLTKS PAGAYQWEAV
360 370 380 390 400
NLREEDLAPD AEDPNVKVPP MMMTTDLALR FDPEYEKIAR RFYENPEEFA
410 420 430 440 450
DAFARAWFKL THRDMGPKTR YLGPEVPKED FIWQDPIPTV DYELSDAEIE
460 470 480 490 500
EIKAKILNSG LTVSELVKTA WASASTFRNS DKRGGANGAR IRLAPQKDWE
510 520 530 540 550
VNEPERLAKV LSVYEDIQRE LPKKVSIADL IVLGGSAAVE KAARDAGFDV
560 570 580 590 600
KVPFIPGRGD ATQEQTDVES FSVLEPFADG FRNYQKKEYS VGPEELLIDK
610 620 630 640 650
AQLLGLTAPE MTVLVGGLRV LGANYRDLPH GVFTDRIGVL TNDFFVNLVD
660 670 680 690 700
MNYEWVPTEG GIYEIRDRQT GEVRWTATRV DLIFGANSIL RSYAEFYAQD
710 720 730
DNREKFVRDF INAWVKVMNA DRFDIHLKQA KESVTV
Length:736
Mass (Da):83,226
Last modified:February 1, 2005 - v1
Checksum:i1ED9B5D025BFAE8C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000043 Genomic DNA. Translation: BAD75995.1.
RefSeqiWP_011231203.1. NC_006510.1.

Genome annotation databases

EnsemblBacteriaiBAD75995; BAD75995; GK1710.
GeneIDi3183999.
KEGGigka:GK1710.
PATRICi21964741. VBIGeoKau81518_1835.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000043 Genomic DNA. Translation: BAD75995.1.
RefSeqiWP_011231203.1. NC_006510.1.

3D structure databases

ProteinModelPortaliQ5KZ91.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi235909.GK1710.

Protein family/group databases

PeroxiBasei2370. GkaCP01_HTA426.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD75995; BAD75995; GK1710.
GeneIDi3183999.
KEGGigka:GK1710.
PATRICi21964741. VBIGeoKau81518_1835.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_GEOKA
AccessioniPrimary (citable) accession number: Q5KZ91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: February 1, 2005
Last modified: November 2, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.