Dihydrofolate reductase - Geobacillus kaustophilus (strain HTA426)

Contribute

Read comments (?) or add your own

Q5KZ26 (Q5KZ26_GEOKA) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 47. History...

Clusters with 100%, 90%, 50% identity |

Third-party data

text xml rdf/xml gff fasta

to top of page

Names·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info Customize order

to top of page

Names·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info Customize order

Names and origin

Protein names

Submitted name:
Dihydrofolate reductase EMBL BAD76060.1
EC=1.5.1.3 EMBL BAD76060.1

Gene names

Ordered Locus Names:

GK1775

Organism

Geobacillus kaustophilus (strain HTA426) [Complete proteome] [HAMAP]

Taxonomic identifier

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Geobacillus

Protein attributes

Sequence length	164 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the dihydrofolate reductase family. RuleBase RU004474

Ontologies

Keywords
Molecular function	Oxidoreductase EMBL BAD76060.1
Technical term	3D-structure PDB 1ZDR Complete proteome
Gene Ontology (GO)
Biological process	glycine biosynthetic process Inferred from electronic annotation. Source: InterPro nucleotide biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro dihydrofolate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

Sequence

Length

Mass (Da)

Tools

Q5KZ26 [UniParc].

Last modified February 1, 2005. Version 1.
Checksum: FA842EAF2A24706E
Show »

164

18,794

        10         20         30         40         50         60 
MISHIVAMDE NRVIGKDNRL PWHLPADLAY FKRVTMGHAI VMGRKTFEAI GRPLPGRDNV 

        70         80         90        100        110        120 
VVTRNRSFRP EGCLVLHSLE EVKQWIASRA DEVFIIGGAE LFRATMPIVD RLYVTKIFAS 

       130        140        150        160 
FPGDTFYPPI SDDEWEIVSY TPGGKDEKNP YEHAFIIYER KKAK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Thermoadaptation trait revealed by the genome sequence of thermophilic Geobacillus kaustophilus." Takami H., Takaki Y., Chee G.-J., Nishi S., Shimamura S., Suzuki H., Matsui S., Uchiyama I. Nucleic Acids Res. 32:6292-6303(2004) [PubMed: 15576355] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HTA426.
[2]	"Structure and hydride transfer mechanism of a moderate thermophilic dihydrofolate reductase from Bacillus stearothermophilus and comparison to its mesophilic and hyperthermophilic homologues." Kim H.S., Damo S.M., Lee S.Y., Wemmer D., Klinman J.P. Biochemistry 44:11428-11439(2005) [PubMed: 16114879] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

BA000043 Genomic DNA. Translation: BAD76060.1.

RefSeq

YP_147628.1. NC_006510.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1ZDR	X-ray	2.00	A/B	1-164	[»]

ProteinModelPortal

SMR

Q5KZ26. Positions 1-161.

ModBase

Protocols and materials databases

StructuralBiologyKnowledgebase

Genome annotation databases

GeneID

GenomeReviews

Gene locus GK1775 in contig BA000043_GR.

KEGG

NMPDR

fig|235909.3.peg.624.

PATRIC

21964889. VBIGeoKau81518_1901.

Organism-specific databases

CMR

Phylogenomic databases

HOGENOM

OMA

ProtClustDB

Family and domain databases

InterPro

IPR012259. DHFR.
IPR024072. DHFR-like_dom.
IPR017925. DHFR_CS.
IPR001796. DHFR_dom.
[Graphical view]

Gene3D

G3DSA:3.40.430.10. G3DSA:3.40.430.10. 1 hit.

KO

PANTHER

PTHR11549:SF1. DHFR. 1 hit.

Pfam

PF00186. DHFR_1. 1 hit.
[Graphical view]

PIRSF

PIRSF000194. DHFR. 1 hit.

PRINTS

PR00070. DHFR.

SUPFAM

SSF53597. SSF53597. 1 hit.

PROSITE

PS00075. DHFR_1. 1 hit.
PS51330. DHFR_2. 1 hit.
[Graphical view]

ProtoNet

Entry information

Entry name

Q5KZ26_GEOKA

Accession

Primary (citable) accession number: Q5KZ26

Entry history

Integrated into UniProtKB/TrEMBL:	February 1, 2005
Last sequence update:	February 1, 2005
Last modified:	January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

to top of page

Names·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info