Q5KYP7 (ARAA_GEOKA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
L-arabinose isomerase
EC=5.3.1.4

Gene names

Name:	araA
Ordered Locus Names:	GK1904

Organism

Geobacillus kaustophilus (strain HTA426) [Complete proteome] [HAMAP]

Taxonomic identifier

235909 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Geobacillus

Protein attributes

Sequence length	496 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of L-arabinose to L-ribulose By similarity. HAMAP MF_00519
Catalytic activity	L-arabinose = L-ribulose. HAMAP MF_00519
Cofactor	Binds 1 manganese ion per subunit By similarity. HAMAP MF_00519
Pathway	Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 1/3. HAMAP MF_00519
Sequence similarities	Belongs to the arabinose isomerase family.
Sequence caution	The sequence BAD76189.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Arabinose catabolism Carbohydrate metabolism
Ligand	Manganese Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arabinose catabolic process Inferred from electronic annotation. Source: UniProtKB-KW fucose metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	L-arabinose isomerase activity Inferred from electronic annotation. Source: EC L-fucose isomerase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 496	496	L-arabinose isomerase HAMAP MF_00519		PRO_0000259339
Sites
	Metal binding	306	1	Manganese By similarity
	Metal binding	331	1	Manganese By similarity
	Metal binding	348	1	Manganese By similarity
	Metal binding	447	1	Manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5KYP7 [UniParc]. Last modified October 31, 2006. Version 2. Checksum: DE7429FB763DFDF9	FASTA	496	56,105
	10 20 30 40 50 60 MLSLRPYEFW FVTGSQHLYG EEALKQVEEH SRIMVNEWNR DSVFPFPFVF KSVVTTPEEI 70 80 90 100 110 120 RRVCLEANAS EQCAGVVTWM HTFSPAKMWI GGLLELRKPL LHLHTQFNRD IPWDSIDMDF 130 140 150 160 170 180 MNLNQSAHGD REYGFIGARM GVARKVVVGH WEDPEVRERL AKWMRTAVAF AESRNLKVAR 190 200 210 220 230 240 FGDNMREVAV TEGDKVGAQI QFGWSVNGYG IGDLVQYIRD VSEQKVNELL DEYEELYDIV 250 260 270 280 290 300 PAGRQEGPVR ESIREQARIE LGLKAFLQDG NFTAFTTTFE DLHGMKQLPG LAVQRLMAEG 310 320 330 340 350 360 YGFGGEGDWK TAALVRLMKV MADGKGTSFM EDYTYHFEPG NELILGAHML EVCPTIAATR 370 380 390 400 410 420 PRVEVHPLSI GGKEDPARLV FDGGEGAAVN ASLIDLGHRF RLIVNEVDAV KPEHDMPKLP 430 440 450 460 470 480 VARILWKPRP SLRDSAEAWI LAGGAHHTCF SFAVTTEQLQ DFAEMAGIEC VVINEHTSVS 490 SFKNELKWNE VFWRGR

References

[1]

"Thermoadaptation trait revealed by the genome sequence of thermophilic Geobacillus kaustophilus." Takami H., Takaki Y., Chee G.-J., Nishi S., Shimamura S., Suzuki H., Matsui S., Uchiyama I. Nucleic Acids Res. 32:6292-6303(2004) [PubMed: 15576355] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HTA426.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000043 Genomic DNA. Translation: BAD76189.1. Different initiation.
RefSeq	YP_147757.1. NC_006510.1.
3D structure databases
HSSP	HSSP built from PDB template 2AJT based on UniProtKB P08202.
ProteinModelPortal	Q5KYP7.
SMR	Q5KYP7. Positions 7-493.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3185813.
GenomeReviews	Gene locus GK1904 in contig BA000043_GR.
KEGG	gka:GK1904.
NMPDR	fig|235909.3.peg.753.
PATRIC	21965173. VBIGeoKau81518_2042.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG297198.
OMA	EVCPTIA.
ProtClustDB	PRK02929.
Enzyme and pathway databases
BioCyc	GKAU235909:GK1904-MONOMER.
Family and domain databases
HAMAP	MF_00519. Arabinose_Isome. [Tree]
InterPro	IPR024664. Ara_Isoase_C. IPR004216. Fuc/Ara_isomerase_C. IPR009015. Fucose_isomerase_N/cen. IPR003762. Lara_isomerase. [Graphical view]
KO	K01804.
Pfam	PF11762. Arabinose_Iso_C. 1 hit. PF02610. Arabinose_Isome. 1 hit. [Graphical view]
PIRSF	PIRSF001478. L-ara_isomerase. 1 hit.
ProDom	PD018364. Lara_isomerase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF50443. Fuc_isomerase_C. 1 hit. SSF53743. Fuc_isomerase_N. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARAA_GEOKA

Accession

Primary (citable) accession number: Q5KYP7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	October 31, 2006
Last modified:	January 25, 2012
This is version 43 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program