Reviewed, UniProtKB/Swiss-Prot Q5KYK6 (MTLD_GEOKA)

Names and origin

Protein names

Recommended name:
    Mannitol-1-phosphate 5-dehydrogenase
    EC=1.1.1.17

Gene names

Name:	mtlD
Ordered Locus Names:	GK1945

Organism

Geobacillus kaustophilus [Complete proteome] [HAMAP]

Taxonomic identifier

1462 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Geobacillus

Protein attributes

Sequence length	387 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. HAMAP MF_00196
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 387	387	Mannitol-1-phosphate 5-dehydrogenase HAMAP MF_00196		PRO_1000011799
Regions
	Nucleotide binding	3 – 14	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5KYK6-1 [UniParc]. Last modified February 1, 2005. Version 1. Checksum: 513DC6F6976DE6C0	FASTA	387	42,363
	10 20 30 40 50 60 MRAVHFGAGN IGRGFIGSLL AASGYDVVFV DVNEQIVRLL KERGEYRVIV AGEQREEQWV 70 80 90 100 110 120 RGVSALNSQT EREKVIEVIA DADLVTTAVG PPILPAIAPV VAAGLQRRFA IQQKPLHVIA 130 140 150 160 170 180 CENMIAGTEA LKQHVLAHLS EAEQQLASEH VGFLNCAVDR IVPNQTNDDP LAVTVEPFFE 190 200 210 220 230 240 WAIEARNVIG TVPPIQGAHF VADLGPYIER KLFTVNTGHA LAAYLGYLRN YKTVQEAMND 250 260 270 280 290 300 EGIRLNVEQA LSESGAVLVK KHGWSEKEHH AYIDTTIGRF MNPSLSDDIL RVARSPIRKL 310 320 330 340 350 360 GPNDRLVAPA VQYCALFGKV PHGLAKGIAA LLRFDDSRDA EAAALQQTIA QHGIEGALRQ 370 380 YAGLESAHPL VAAVREEYDQ MDENKRL

References

[1]

"Thermoadaptation trait revealed by the genome sequence of thermophilic Geobacillus kaustophilus." Takami H., Takaki Y., Chee G.-J., Nishi S., Shimamura S., Suzuki H., Matsui S., Uchiyama I. Nucleic Acids Res. 32:6292-6303(2004) [PubMed: 15576355] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HTA426.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000043 Genomic DNA. Translation: BAD76230.1.
RefSeq	YP_147798.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3185506.
GenomeReviews	Gene locus GK1945 in contig BA000043_GR.
KEGG	gka:GK1945.
NMPDR	fig|235909.3.peg.794.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q5KYK6.
OMA	Q5KYK6. VDRIVPN.
Enzyme and pathway databases
BioCyc	GKAU235909:GK1945-MON.
BRENDA	1.1.1.17. 281547.
Family and domain databases
HAMAP	MF_00196. [Tree]
InterPro	IPR013328. DH_multihelical. IPR013118. Mannitol_DH_C. IPR000669. Mannitol_DH_core. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
PROSITE	PS00974. MANNITOL_DHGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_GEOKA

Accession

Primary (citable) accession number: Q5KYK6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 1, 2005
Last modified:	June 16, 2009
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)