ID   Q5KYI5_GEOKA            Unreviewed;       488 AA.
AC   Q5KYI5;
DT   01-FEB-2005, integrated into UniProtKB/TrEMBL.
DT   01-FEB-2005, sequence version 1.
DT   27-MAR-2024, entry version 97.
DE   SubName: Full=Aldehyde dehydrogenase {ECO:0000313|EMBL:BAD76251.1};
GN   OrderedLocusNames=GK1966 {ECO:0000313|EMBL:BAD76251.1};
OS   Geobacillus kaustophilus (strain HTA426).
OC   Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Geobacillus;
OC   Geobacillus thermoleovorans group.
OX   NCBI_TaxID=235909 {ECO:0000313|EMBL:BAD76251.1, ECO:0000313|Proteomes:UP000001172};
RN   [1] {ECO:0000313|EMBL:BAD76251.1, ECO:0000313|Proteomes:UP000001172}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HTA426 {ECO:0000313|EMBL:BAD76251.1,
RC   ECO:0000313|Proteomes:UP000001172};
RX   PubMed=15576355; DOI=10.1093/nar/gkh970;
RA   Takami H., Takaki Y., Chee G.J., Nishi S., Shimamura S., Suzuki H.,
RA   Matsui S., Uchiyama I.;
RT   "Thermoadaptation trait revealed by the genome sequence of thermophilic
RT   Geobacillus kaustophilus.";
RL   Nucleic Acids Res. 32:6292-6303(2004).
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU003345}.
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DR   EMBL; BA000043; BAD76251.1; -; Genomic_DNA.
DR   RefSeq; WP_011231452.1; NC_006510.1.
DR   AlphaFoldDB; Q5KYI5; -.
DR   STRING; 235909.GK1966; -.
DR   KEGG; gka:GK1966; -.
DR   PATRIC; fig|235909.7.peg.2106; -.
DR   eggNOG; COG1012; Bacteria.
DR   HOGENOM; CLU_005391_1_0_9; -.
DR   Proteomes; UP000001172; Chromosome.
DR   GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   CDD; cd07097; ALDH_KGSADH-YcbD; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   PANTHER; PTHR11699:SF211; ALDEHYDE DEHYDROGENASE FAMILY 16 MEMBER A1; 1.
DR   PANTHER; PTHR11699; ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU003345};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001172}.
FT   DOMAIN          18..484
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   ACT_SITE        255
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ   SEQUENCE   488 AA;  52747 MW;  ABEE0A290A5AD9C3 CRC64;
     MAVQTEIKTY LNYIDGSWVG SVSKNVEPSI NPANRNDIVG YVPRSTLEDL NAAVAAAKQA
     QKSWWKRSGI ERGEYLYKAA LLLEQRLEDI AETMTREMGK TLAEAKAETM RGVHILRYYA
     GEGARKIGDV IPSSDSGGLM FTTRVPLGVV GVISPWNFPV AIPIWKMAPA LVYGNTVVLK
     PASETAVTAA KVIECFHEAG FPKGVVNMVC GSGSVIGQGI ANHPDVDGVT FTGSNTVGKQ
     VGRAAFERGA KYQLEMGGKN PVIVAKDADL DLAVEGTISG GLRSTGQKCT ATSRVFIERE
     VYEPFKEKLL ERVKQLKIGN GMDAETWMGP CASESQLNTV LSYIEKGKAE GAKLIYGGNR
     CTEGELANGF YVEPTIFEEV DLQMTIAREE IFGPVLVLIP VDSIEEAIEL ANDTEYGLSA
     SIYTKNIGNI LDFIKDIEAG LVKVNAETAG VEYQAPFGGM KQSSSHSREQ GQAAIEFFTT
     IKTVFVKA
//