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Q5KYA2

- PROA_GEOKA

UniProt

Q5KYA2 - PROA_GEOKA

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Protein
Gamma-glutamyl phosphate reductase
Gene
proA, GK2049
Organism
Geobacillus kaustophilus (strain HTA426)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate By similarity.

Catalytic activityi

L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. NADP binding Source: InterPro
  2. glutamate-5-semialdehyde dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-proline biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Proline biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciGKAU235909:GJO7-2137-MONOMER.
UniPathwayiUPA00098; UER00360.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-glutamyl phosphate reductase (EC:1.2.1.41)
Short name:
GPR
Alternative name(s):
Glutamate-5-semialdehyde dehydrogenase
Glutamyl-gamma-semialdehyde dehydrogenase
Short name:
GSA dehydrogenase
Gene namesi
Name:proA
Ordered Locus Names:GK2049
OrganismiGeobacillus kaustophilus (strain HTA426)
Taxonomic identifieri235909 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
ProteomesiUP000001172: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 414414Gamma-glutamyl phosphate reductaseUniRule annotation
PRO_0000189728Add
BLAST

Proteomic databases

PRIDEiQ5KYA2.

Interactioni

Protein-protein interaction databases

STRINGi235909.GK2049.

Structurei

3D structure databases

ProteinModelPortaliQ5KYA2.
SMRiQ5KYA2. Positions 3-413.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0014.
HOGENOMiHOG000246356.
KOiK00147.
OMAiALTSYKW.
OrthoDBiEOG6FFSCX.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 2 hits.
HAMAPiMF_00412. ProA.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR000965. G-glutamylP_reductase.
IPR020593. G-glutamylP_reductase_CS.
IPR012134. Glu-5-SA_DH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFiPIRSF000151. GPR. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00407. proA. 1 hit.
PROSITEiPS01223. PROA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5KYA2-1 [UniParc]FASTAAdd to Basket

« Hide

MSELLEKAER LKTASQTLAM LSAEEKNEAL EQIAQTLDRE RAFILQENEK    50
DMAQGREQGL SPALLDRLQL TNERLDQIID GVRQVASLPD PVGEIIAEWT 100
RPNGLRIQTV RVPLGVIGMV YEARPNVTVD AASLCLKTGN AVLLRGSTSA 150
LHSNKALVAV MKEALRTTAI PETAIELLED TSRETAQRMF RLNNYLDVLI 200
PRGGAGLIRS VVENATVPVL ETGVGNCHIF VDESAERQMA IEIVLNAKLQ 250
RPSVCNAVET VLIHERWPYA ADLLETLHAR GVELRGDQRL ASAYPFISEA 300
TEDDWYTEYL APILAVKLVA DVDEAIGHIR RYGTKHSEAI ITENEVNVRR 350
FFQAVDAAVL YHNASTRFTD GEQFGYGAEI GISTQKLHAR GPMGLVAITT 400
TKSLVYGTGQ IRTV 414
Length:414
Mass (Da):45,650
Last modified:February 1, 2005 - v1
Checksum:iD57558B51B02E565
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000043 Genomic DNA. Translation: BAD76334.1.
RefSeqiYP_147902.1. NC_006510.1.

Genome annotation databases

EnsemblBacteriaiBAD76334; BAD76334; GK2049.
GeneIDi3186428.
KEGGigka:GK2049.
PATRICi21965487. VBIGeoKau81518_2199.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000043 Genomic DNA. Translation: BAD76334.1 .
RefSeqi YP_147902.1. NC_006510.1.

3D structure databases

ProteinModelPortali Q5KYA2.
SMRi Q5KYA2. Positions 3-413.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 235909.GK2049.

Proteomic databases

PRIDEi Q5KYA2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD76334 ; BAD76334 ; GK2049 .
GeneIDi 3186428.
KEGGi gka:GK2049.
PATRICi 21965487. VBIGeoKau81518_2199.

Phylogenomic databases

eggNOGi COG0014.
HOGENOMi HOG000246356.
KOi K00147.
OMAi ALTSYKW.
OrthoDBi EOG6FFSCX.

Enzyme and pathway databases

UniPathwayi UPA00098 ; UER00360 .
BioCyci GKAU235909:GJO7-2137-MONOMER.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 2 hits.
HAMAPi MF_00412. ProA.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR000965. G-glutamylP_reductase.
IPR020593. G-glutamylP_reductase_CS.
IPR012134. Glu-5-SA_DH.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000151. GPR. 1 hit.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00407. proA. 1 hit.
PROSITEi PS01223. PROA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Thermoadaptation trait revealed by the genome sequence of thermophilic Geobacillus kaustophilus."
    Takami H., Takaki Y., Chee G.-J., Nishi S., Shimamura S., Suzuki H., Matsui S., Uchiyama I.
    Nucleic Acids Res. 32:6292-6303(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HTA426.

Entry informationi

Entry nameiPROA_GEOKA
AccessioniPrimary (citable) accession number: Q5KYA2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: February 1, 2005
Last modified: September 3, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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