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Q5KYA2

- PROA_GEOKA

UniProt

Q5KYA2 - PROA_GEOKA

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Protein

Gamma-glutamyl phosphate reductase

Gene

proA

Organism
Geobacillus kaustophilus (strain HTA426)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.UniRule annotation

Catalytic activityi

L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-5-semialdehyde dehydrogenase activity Source: UniProtKB-HAMAP
  2. NADP binding Source: InterPro

GO - Biological processi

  1. L-proline biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Proline biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciGKAU235909:GJO7-2137-MONOMER.
UniPathwayiUPA00098; UER00360.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-glutamyl phosphate reductaseUniRule annotation (EC:1.2.1.41UniRule annotation)
Short name:
GPRUniRule annotation
Alternative name(s):
Glutamate-5-semialdehyde dehydrogenaseUniRule annotation
Glutamyl-gamma-semialdehyde dehydrogenaseUniRule annotation
Short name:
GSA dehydrogenaseUniRule annotation
Gene namesi
Name:proAUniRule annotation
Ordered Locus Names:GK2049
OrganismiGeobacillus kaustophilus (strain HTA426)
Taxonomic identifieri235909 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
ProteomesiUP000001172: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 414414Gamma-glutamyl phosphate reductasePRO_0000189728Add
BLAST

Proteomic databases

PRIDEiQ5KYA2.

Interactioni

Protein-protein interaction databases

STRINGi235909.GK2049.

Structurei

3D structure databases

ProteinModelPortaliQ5KYA2.
SMRiQ5KYA2. Positions 3-413.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the gamma-glutamyl phosphate reductase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0014.
HOGENOMiHOG000246356.
KOiK00147.
OMAiALTSYKW.
OrthoDBiEOG6FFSCX.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 2 hits.
HAMAPiMF_00412. ProA.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR000965. G-glutamylP_reductase.
IPR020593. G-glutamylP_reductase_CS.
IPR012134. Glu-5-SA_DH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFiPIRSF000151. GPR. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00407. proA. 1 hit.
PROSITEiPS01223. PROA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5KYA2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSELLEKAER LKTASQTLAM LSAEEKNEAL EQIAQTLDRE RAFILQENEK
60 70 80 90 100
DMAQGREQGL SPALLDRLQL TNERLDQIID GVRQVASLPD PVGEIIAEWT
110 120 130 140 150
RPNGLRIQTV RVPLGVIGMV YEARPNVTVD AASLCLKTGN AVLLRGSTSA
160 170 180 190 200
LHSNKALVAV MKEALRTTAI PETAIELLED TSRETAQRMF RLNNYLDVLI
210 220 230 240 250
PRGGAGLIRS VVENATVPVL ETGVGNCHIF VDESAERQMA IEIVLNAKLQ
260 270 280 290 300
RPSVCNAVET VLIHERWPYA ADLLETLHAR GVELRGDQRL ASAYPFISEA
310 320 330 340 350
TEDDWYTEYL APILAVKLVA DVDEAIGHIR RYGTKHSEAI ITENEVNVRR
360 370 380 390 400
FFQAVDAAVL YHNASTRFTD GEQFGYGAEI GISTQKLHAR GPMGLVAITT
410
TKSLVYGTGQ IRTV
Length:414
Mass (Da):45,650
Last modified:February 1, 2005 - v1
Checksum:iD57558B51B02E565
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000043 Genomic DNA. Translation: BAD76334.1.
RefSeqiYP_147902.1. NC_006510.1.

Genome annotation databases

EnsemblBacteriaiBAD76334; BAD76334; GK2049.
GeneIDi3186428.
KEGGigka:GK2049.
PATRICi21965487. VBIGeoKau81518_2199.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000043 Genomic DNA. Translation: BAD76334.1 .
RefSeqi YP_147902.1. NC_006510.1.

3D structure databases

ProteinModelPortali Q5KYA2.
SMRi Q5KYA2. Positions 3-413.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 235909.GK2049.

Proteomic databases

PRIDEi Q5KYA2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD76334 ; BAD76334 ; GK2049 .
GeneIDi 3186428.
KEGGi gka:GK2049.
PATRICi 21965487. VBIGeoKau81518_2199.

Phylogenomic databases

eggNOGi COG0014.
HOGENOMi HOG000246356.
KOi K00147.
OMAi ALTSYKW.
OrthoDBi EOG6FFSCX.

Enzyme and pathway databases

UniPathwayi UPA00098 ; UER00360 .
BioCyci GKAU235909:GJO7-2137-MONOMER.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 2 hits.
HAMAPi MF_00412. ProA.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR000965. G-glutamylP_reductase.
IPR020593. G-glutamylP_reductase_CS.
IPR012134. Glu-5-SA_DH.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000151. GPR. 1 hit.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00407. proA. 1 hit.
PROSITEi PS01223. PROA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Thermoadaptation trait revealed by the genome sequence of thermophilic Geobacillus kaustophilus."
    Takami H., Takaki Y., Chee G.-J., Nishi S., Shimamura S., Suzuki H., Matsui S., Uchiyama I.
    Nucleic Acids Res. 32:6292-6303(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HTA426.

Entry informationi

Entry nameiPROA_GEOKA
AccessioniPrimary (citable) accession number: Q5KYA2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: February 1, 2005
Last modified: October 29, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3