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Q5KY26

- GLSA_GEOKA

UniProt

Q5KY26 - GLSA_GEOKA

Protein

Glutaminase

Gene

glsA

Organism
Geobacillus kaustophilus (strain HTA426)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (01 Feb 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei65 – 651SubstrateUniRule annotation
    Binding sitei116 – 1161SubstrateUniRule annotation
    Binding sitei161 – 1611SubstrateUniRule annotation
    Binding sitei168 – 1681SubstrateUniRule annotation
    Binding sitei192 – 1921SubstrateUniRule annotation
    Binding sitei244 – 2441SubstrateUniRule annotation
    Binding sitei262 – 2621Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. glutaminase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glutamine metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciGKAU235909:GJO7-2213-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GlutaminaseUniRule annotation (EC:3.5.1.2UniRule annotation)
    Gene namesi
    Name:glsAUniRule annotation
    Ordered Locus Names:GK2125
    OrganismiGeobacillus kaustophilus (strain HTA426)
    Taxonomic identifieri235909 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
    ProteomesiUP000001172: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 308308GlutaminasePRO_1000048336Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi235909.GK2125.

    Structurei

    Secondary structure

    1
    308
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi6 – 1712
    Helixi18 – 225
    Helixi30 – 345
    Beta strandi41 – 466
    Turni47 – 493
    Beta strandi50 – 567
    Helixi66 – 8722
    Helixi116 – 1238
    Beta strandi128 – 1303
    Helixi131 – 14616
    Helixi155 – 16410
    Helixi166 – 17712
    Helixi185 – 19612
    Beta strandi198 – 2003
    Helixi202 – 21312
    Turni214 – 2163
    Turni219 – 2213
    Beta strandi224 – 2263
    Helixi228 – 24013
    Beta strandi241 – 2433
    Helixi247 – 2537
    Beta strandi258 – 2603
    Beta strandi264 – 2707
    Turni271 – 2733
    Beta strandi274 – 2796
    Beta strandi287 – 2893
    Helixi290 – 30314

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2PBYX-ray2.07A/B/C/D1-308[»]
    ProteinModelPortaliQ5KY26.
    SMRiQ5KY26. Positions 2-308.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ5KY26.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glutaminase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2066.
    HOGENOMiHOG000216890.
    KOiK01425.
    OMAiQRARRIN.
    OrthoDBiEOG6N94BK.

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    HAMAPiMF_00313. Glutaminase.
    InterProiIPR012338. Beta-lactam/transpept-like.
    IPR015868. Glutaminase.
    [Graphical view]
    PANTHERiPTHR12544. PTHR12544. 1 hit.
    PfamiPF04960. Glutaminase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56601. SSF56601. 1 hit.
    TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5KY26-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLVYNQEELV RFVEEAKQYA RYGKVADYIP ALGKANPNEL SIAIYTPDDE    50
    VVSAGDVTVK VTLQSISKII ALALVLIDRG EDEVFHKVGM EPTDYPFHSI 100
    AKLEEKPAKP LNPMINAGAL VVTSMIQGGS VSERLERLLA FVRRLAGNER 150
    ISYSDEVARS EFETAFLNRS LCYFLKQHRI IDEDVEELME LYTKQCAIEM 200
    TCIDLARIGL VLALDGRDPH SSEPLMPLDV ARICKTFMVT CGMYNSSGEF 250
    AIKVGIPAKS GVSGGILAAV PGRCGIGVFG PALDDKGNSL TGVKLLERLS 300
    KTYSLSIF 308
    Length:308
    Mass (Da):33,773
    Last modified:February 1, 2005 - v1
    Checksum:i9D8954EFFC212BB9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000043 Genomic DNA. Translation: BAD76410.1.
    RefSeqiWP_011231610.1. NC_006510.1.
    YP_147978.1. NC_006510.1.

    Genome annotation databases

    EnsemblBacteriaiBAD76410; BAD76410; GK2125.
    GeneIDi3186387.
    KEGGigka:GK2125.
    PATRICi21965645. VBIGeoKau81518_2278.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000043 Genomic DNA. Translation: BAD76410.1 .
    RefSeqi WP_011231610.1. NC_006510.1.
    YP_147978.1. NC_006510.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2PBY X-ray 2.07 A/B/C/D 1-308 [» ]
    ProteinModelPortali Q5KY26.
    SMRi Q5KY26. Positions 2-308.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 235909.GK2125.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD76410 ; BAD76410 ; GK2125 .
    GeneIDi 3186387.
    KEGGi gka:GK2125.
    PATRICi 21965645. VBIGeoKau81518_2278.

    Phylogenomic databases

    eggNOGi COG2066.
    HOGENOMi HOG000216890.
    KOi K01425.
    OMAi QRARRIN.
    OrthoDBi EOG6N94BK.

    Enzyme and pathway databases

    BioCyci GKAU235909:GJO7-2213-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q5KY26.

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    HAMAPi MF_00313. Glutaminase.
    InterProi IPR012338. Beta-lactam/transpept-like.
    IPR015868. Glutaminase.
    [Graphical view ]
    PANTHERi PTHR12544. PTHR12544. 1 hit.
    Pfami PF04960. Glutaminase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56601. SSF56601. 1 hit.
    TIGRFAMsi TIGR03814. Gln_ase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Thermoadaptation trait revealed by the genome sequence of thermophilic Geobacillus kaustophilus."
      Takami H., Takaki Y., Chee G.-J., Nishi S., Shimamura S., Suzuki H., Matsui S., Uchiyama I.
      Nucleic Acids Res. 32:6292-6303(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HTA426.

    Entry informationi

    Entry nameiGLSA_GEOKA
    AccessioniPrimary (citable) accession number: Q5KY26
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3