Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glutaminase

Gene

glsA

Organism
Geobacillus kaustophilus (strain HTA426)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei65SubstrateUniRule annotation1
Binding sitei116SubstrateUniRule annotation1
Binding sitei161SubstrateUniRule annotation1
Binding sitei168SubstrateUniRule annotation1
Binding sitei192SubstrateUniRule annotation1
Binding sitei244SubstrateUniRule annotation1
Binding sitei262Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
GlutaminaseUniRule annotation (EC:3.5.1.2UniRule annotation)
Gene namesi
Name:glsAUniRule annotation
Ordered Locus Names:GK2125
OrganismiGeobacillus kaustophilus (strain HTA426)
Taxonomic identifieri235909 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
Proteomesi
  • UP000001172 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000483361 – 308GlutaminaseAdd BLAST308

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi235909.GK2125.

Structurei

Secondary structure

1308
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 17Combined sources12
Helixi18 – 22Combined sources5
Helixi30 – 34Combined sources5
Beta strandi41 – 46Combined sources6
Turni47 – 49Combined sources3
Beta strandi50 – 56Combined sources7
Helixi66 – 87Combined sources22
Helixi116 – 123Combined sources8
Beta strandi128 – 130Combined sources3
Helixi131 – 146Combined sources16
Helixi155 – 164Combined sources10
Helixi166 – 177Combined sources12
Helixi185 – 196Combined sources12
Beta strandi198 – 200Combined sources3
Helixi202 – 213Combined sources12
Turni214 – 216Combined sources3
Turni219 – 221Combined sources3
Beta strandi224 – 226Combined sources3
Helixi228 – 240Combined sources13
Beta strandi241 – 243Combined sources3
Helixi247 – 253Combined sources7
Beta strandi258 – 260Combined sources3
Beta strandi264 – 270Combined sources7
Turni271 – 273Combined sources3
Beta strandi274 – 279Combined sources6
Beta strandi287 – 289Combined sources3
Helixi290 – 303Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PBYX-ray2.07A/B/C/D1-308[»]
ProteinModelPortaliQ5KY26.
SMRiQ5KY26.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5KY26.

Family & Domainsi

Sequence similaritiesi

Belongs to the glutaminase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CSV. Bacteria.
COG2066. LUCA.
HOGENOMiHOG000216890.
KOiK01425.
OMAiANYMKSF.
OrthoDBiPOG091H02PU.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5KY26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVYNQEELV RFVEEAKQYA RYGKVADYIP ALGKANPNEL SIAIYTPDDE
60 70 80 90 100
VVSAGDVTVK VTLQSISKII ALALVLIDRG EDEVFHKVGM EPTDYPFHSI
110 120 130 140 150
AKLEEKPAKP LNPMINAGAL VVTSMIQGGS VSERLERLLA FVRRLAGNER
160 170 180 190 200
ISYSDEVARS EFETAFLNRS LCYFLKQHRI IDEDVEELME LYTKQCAIEM
210 220 230 240 250
TCIDLARIGL VLALDGRDPH SSEPLMPLDV ARICKTFMVT CGMYNSSGEF
260 270 280 290 300
AIKVGIPAKS GVSGGILAAV PGRCGIGVFG PALDDKGNSL TGVKLLERLS

KTYSLSIF
Length:308
Mass (Da):33,773
Last modified:February 1, 2005 - v1
Checksum:i9D8954EFFC212BB9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000043 Genomic DNA. Translation: BAD76410.1.
RefSeqiWP_011231610.1. NC_006510.1.

Genome annotation databases

EnsemblBacteriaiBAD76410; BAD76410; GK2125.
GeneIDi3186387.
KEGGigka:GK2125.
PATRICi21965645. VBIGeoKau81518_2278.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000043 Genomic DNA. Translation: BAD76410.1.
RefSeqiWP_011231610.1. NC_006510.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PBYX-ray2.07A/B/C/D1-308[»]
ProteinModelPortaliQ5KY26.
SMRiQ5KY26.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi235909.GK2125.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD76410; BAD76410; GK2125.
GeneIDi3186387.
KEGGigka:GK2125.
PATRICi21965645. VBIGeoKau81518_2278.

Phylogenomic databases

eggNOGiENOG4105CSV. Bacteria.
COG2066. LUCA.
HOGENOMiHOG000216890.
KOiK01425.
OMAiANYMKSF.
OrthoDBiPOG091H02PU.

Miscellaneous databases

EvolutionaryTraceiQ5KY26.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGLSA_GEOKA
AccessioniPrimary (citable) accession number: Q5KY26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 1, 2005
Last modified: November 2, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.