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Q5KY26

- GLSA_GEOKA

UniProt

Q5KY26 - GLSA_GEOKA

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Protein

Glutaminase

Gene

glsA

Organism
Geobacillus kaustophilus (strain HTA426)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei65 – 651SubstrateUniRule annotation
Binding sitei116 – 1161SubstrateUniRule annotation
Binding sitei161 – 1611SubstrateUniRule annotation
Binding sitei168 – 1681SubstrateUniRule annotation
Binding sitei192 – 1921SubstrateUniRule annotation
Binding sitei244 – 2441SubstrateUniRule annotation
Binding sitei262 – 2621Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. glutaminase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glutamine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciGKAU235909:GJO7-2213-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
GlutaminaseUniRule annotation (EC:3.5.1.2UniRule annotation)
Gene namesi
Name:glsAUniRule annotation
Ordered Locus Names:GK2125
OrganismiGeobacillus kaustophilus (strain HTA426)
Taxonomic identifieri235909 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
ProteomesiUP000001172: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 308308GlutaminasePRO_1000048336Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi235909.GK2125.

Structurei

Secondary structure

1
308
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 1712Combined sources
Helixi18 – 225Combined sources
Helixi30 – 345Combined sources
Beta strandi41 – 466Combined sources
Turni47 – 493Combined sources
Beta strandi50 – 567Combined sources
Helixi66 – 8722Combined sources
Helixi116 – 1238Combined sources
Beta strandi128 – 1303Combined sources
Helixi131 – 14616Combined sources
Helixi155 – 16410Combined sources
Helixi166 – 17712Combined sources
Helixi185 – 19612Combined sources
Beta strandi198 – 2003Combined sources
Helixi202 – 21312Combined sources
Turni214 – 2163Combined sources
Turni219 – 2213Combined sources
Beta strandi224 – 2263Combined sources
Helixi228 – 24013Combined sources
Beta strandi241 – 2433Combined sources
Helixi247 – 2537Combined sources
Beta strandi258 – 2603Combined sources
Beta strandi264 – 2707Combined sources
Turni271 – 2733Combined sources
Beta strandi274 – 2796Combined sources
Beta strandi287 – 2893Combined sources
Helixi290 – 30314Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PBYX-ray2.07A/B/C/D1-308[»]
ProteinModelPortaliQ5KY26.
SMRiQ5KY26. Positions 2-308.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5KY26.

Family & Domainsi

Sequence similaritiesi

Belongs to the glutaminase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OMAiQRARRIN.
OrthoDBiEOG6N94BK.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5KY26-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLVYNQEELV RFVEEAKQYA RYGKVADYIP ALGKANPNEL SIAIYTPDDE
60 70 80 90 100
VVSAGDVTVK VTLQSISKII ALALVLIDRG EDEVFHKVGM EPTDYPFHSI
110 120 130 140 150
AKLEEKPAKP LNPMINAGAL VVTSMIQGGS VSERLERLLA FVRRLAGNER
160 170 180 190 200
ISYSDEVARS EFETAFLNRS LCYFLKQHRI IDEDVEELME LYTKQCAIEM
210 220 230 240 250
TCIDLARIGL VLALDGRDPH SSEPLMPLDV ARICKTFMVT CGMYNSSGEF
260 270 280 290 300
AIKVGIPAKS GVSGGILAAV PGRCGIGVFG PALDDKGNSL TGVKLLERLS

KTYSLSIF
Length:308
Mass (Da):33,773
Last modified:February 1, 2005 - v1
Checksum:i9D8954EFFC212BB9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000043 Genomic DNA. Translation: BAD76410.1.
RefSeqiYP_147978.1. NC_006510.1.

Genome annotation databases

EnsemblBacteriaiBAD76410; BAD76410; GK2125.
GeneIDi3186387.
KEGGigka:GK2125.
PATRICi21965645. VBIGeoKau81518_2278.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000043 Genomic DNA. Translation: BAD76410.1 .
RefSeqi YP_147978.1. NC_006510.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2PBY X-ray 2.07 A/B/C/D 1-308 [» ]
ProteinModelPortali Q5KY26.
SMRi Q5KY26. Positions 2-308.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 235909.GK2125.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD76410 ; BAD76410 ; GK2125 .
GeneIDi 3186387.
KEGGi gka:GK2125.
PATRICi 21965645. VBIGeoKau81518_2278.

Phylogenomic databases

eggNOGi COG2066.
HOGENOMi HOG000216890.
KOi K01425.
OMAi QRARRIN.
OrthoDBi EOG6N94BK.

Enzyme and pathway databases

BioCyci GKAU235909:GJO7-2213-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q5KY26.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
HAMAPi MF_00313. Glutaminase.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view ]
PANTHERi PTHR12544. PTHR12544. 1 hit.
Pfami PF04960. Glutaminase. 1 hit.
[Graphical view ]
SUPFAMi SSF56601. SSF56601. 1 hit.
TIGRFAMsi TIGR03814. Gln_ase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Thermoadaptation trait revealed by the genome sequence of thermophilic Geobacillus kaustophilus."
    Takami H., Takaki Y., Chee G.-J., Nishi S., Shimamura S., Suzuki H., Matsui S., Uchiyama I.
    Nucleic Acids Res. 32:6292-6303(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HTA426.

Entry informationi

Entry nameiGLSA_GEOKA
AccessioniPrimary (citable) accession number: Q5KY26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 1, 2005
Last modified: November 26, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3