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Q5KY26

- GLSA_GEOKA

UniProt

Q5KY26 - GLSA_GEOKA

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Protein

Glutaminase

Gene
glsA, GK2125
Organism
Geobacillus kaustophilus (strain HTA426)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei65 – 651Substrate By similarity
Binding sitei116 – 1161Substrate By similarity
Binding sitei161 – 1611Substrate By similarity
Binding sitei168 – 1681Substrate By similarity
Binding sitei192 – 1921Substrate By similarity
Binding sitei244 – 2441Substrate By similarity
Binding sitei262 – 2621Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. glutaminase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glutamine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciGKAU235909:GJO7-2213-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaminase (EC:3.5.1.2)
Gene namesi
Name:glsA
Ordered Locus Names:GK2125
OrganismiGeobacillus kaustophilus (strain HTA426)
Taxonomic identifieri235909 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
ProteomesiUP000001172: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 308308GlutaminaseUniRule annotationPRO_1000048336Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi235909.GK2125.

Structurei

Secondary structure

1
308
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 1712
Helixi18 – 225
Helixi30 – 345
Beta strandi41 – 466
Turni47 – 493
Beta strandi50 – 567
Helixi66 – 8722
Helixi116 – 1238
Beta strandi128 – 1303
Helixi131 – 14616
Helixi155 – 16410
Helixi166 – 17712
Helixi185 – 19612
Beta strandi198 – 2003
Helixi202 – 21312
Turni214 – 2163
Turni219 – 2213
Beta strandi224 – 2263
Helixi228 – 24013
Beta strandi241 – 2433
Helixi247 – 2537
Beta strandi258 – 2603
Beta strandi264 – 2707
Turni271 – 2733
Beta strandi274 – 2796
Beta strandi287 – 2893
Helixi290 – 30314

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PBYX-ray2.07A/B/C/D1-308[»]
ProteinModelPortaliQ5KY26.
SMRiQ5KY26. Positions 2-308.

Miscellaneous databases

EvolutionaryTraceiQ5KY26.

Family & Domainsi

Sequence similaritiesi

Belongs to the glutaminase family.

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OMAiQRARRIN.
OrthoDBiEOG6N94BK.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5KY26-1 [UniParc]FASTAAdd to Basket

« Hide

MLVYNQEELV RFVEEAKQYA RYGKVADYIP ALGKANPNEL SIAIYTPDDE    50
VVSAGDVTVK VTLQSISKII ALALVLIDRG EDEVFHKVGM EPTDYPFHSI 100
AKLEEKPAKP LNPMINAGAL VVTSMIQGGS VSERLERLLA FVRRLAGNER 150
ISYSDEVARS EFETAFLNRS LCYFLKQHRI IDEDVEELME LYTKQCAIEM 200
TCIDLARIGL VLALDGRDPH SSEPLMPLDV ARICKTFMVT CGMYNSSGEF 250
AIKVGIPAKS GVSGGILAAV PGRCGIGVFG PALDDKGNSL TGVKLLERLS 300
KTYSLSIF 308
Length:308
Mass (Da):33,773
Last modified:February 1, 2005 - v1
Checksum:i9D8954EFFC212BB9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000043 Genomic DNA. Translation: BAD76410.1.
RefSeqiWP_011231610.1. NC_006510.1.
YP_147978.1. NC_006510.1.

Genome annotation databases

EnsemblBacteriaiBAD76410; BAD76410; GK2125.
GeneIDi3186387.
KEGGigka:GK2125.
PATRICi21965645. VBIGeoKau81518_2278.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000043 Genomic DNA. Translation: BAD76410.1 .
RefSeqi WP_011231610.1. NC_006510.1.
YP_147978.1. NC_006510.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2PBY X-ray 2.07 A/B/C/D 1-308 [» ]
ProteinModelPortali Q5KY26.
SMRi Q5KY26. Positions 2-308.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 235909.GK2125.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD76410 ; BAD76410 ; GK2125 .
GeneIDi 3186387.
KEGGi gka:GK2125.
PATRICi 21965645. VBIGeoKau81518_2278.

Phylogenomic databases

eggNOGi COG2066.
HOGENOMi HOG000216890.
KOi K01425.
OMAi QRARRIN.
OrthoDBi EOG6N94BK.

Enzyme and pathway databases

BioCyci GKAU235909:GJO7-2213-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q5KY26.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
HAMAPi MF_00313. Glutaminase.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view ]
PANTHERi PTHR12544. PTHR12544. 1 hit.
Pfami PF04960. Glutaminase. 1 hit.
[Graphical view ]
SUPFAMi SSF56601. SSF56601. 1 hit.
TIGRFAMsi TIGR03814. Gln_ase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Thermoadaptation trait revealed by the genome sequence of thermophilic Geobacillus kaustophilus."
    Takami H., Takaki Y., Chee G.-J., Nishi S., Shimamura S., Suzuki H., Matsui S., Uchiyama I.
    Nucleic Acids Res. 32:6292-6303(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HTA426.

Entry informationi

Entry nameiGLSA_GEOKA
AccessioniPrimary (citable) accession number: Q5KY26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 1, 2005
Last modified: September 3, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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