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Protein

Ribonuclease Z

Gene

rnz

Organism
Geobacillus kaustophilus (strain HTA426)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi63Zinc 1; catalyticUniRule annotation1
Metal bindingi65Zinc 1; catalyticUniRule annotation1
Active sitei67Proton acceptorUniRule annotation1
Metal bindingi67Zinc 2; catalyticUniRule annotation1
Metal bindingi68Zinc 2; catalyticUniRule annotation1
Metal bindingi140Zinc 1; catalyticUniRule annotation1
Metal bindingi211Zinc 1; catalyticUniRule annotation1
Metal bindingi211Zinc 2; catalyticUniRule annotation1
Metal bindingi269Zinc 2; catalyticUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
Biological processtRNA processing
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease ZUniRule annotation (EC:3.1.26.11UniRule annotation)
Short name:
RNase ZUniRule annotation
Alternative name(s):
tRNA 3 endonucleaseUniRule annotation
tRNase ZUniRule annotation
Gene namesi
Name:rnzUniRule annotation
Ordered Locus Names:GK2333
OrganismiGeobacillus kaustophilus (strain HTA426)
Taxonomic identifieri235909 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillusGeobacillus thermoleovorans group
Proteomesi
  • UP000001172 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001558671 – 307Ribonuclease ZAdd BLAST307

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi235909.GK2333.

Structurei

3D structure databases

ProteinModelPortaliQ5KXG8.
SMRiQ5KXG8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase Z family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105IES. Bacteria.
COG1234. LUCA.
HOGENOMiHOG000272419.
KOiK00784.
OMAiGTQRQMM.
OrthoDBiPOG091H07TH.

Family and domain databases

CDDicd07717. RNaseZ_ZiPD-like_MBL-fold. 1 hit.
Gene3Di3.60.15.10. 1 hit.
HAMAPiMF_01818. RNase_Z_BN. 1 hit.
InterProiView protein in InterPro
IPR001279. Metallo-B-lactamas.
IPR036866. Metallo-hydrolase/OxRdtase.
IPR013471. RNase_Z/BN.
PfamiView protein in Pfam
PF00753. Lactamase_B. 1 hit.
PF12706. Lactamase_B_2. 1 hit.
SUPFAMiSSF56281. SSF56281. 1 hit.
TIGRFAMsiTIGR02651. RNase_Z. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5KXG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELLFLGTGA GVPAKERNVS SVALQLLGER GATWLFDCGE ATQHQILHTA
60 70 80 90 100
IRPRRIEHIF ITHLHGDHLF GLPGLLGSRS FQSGETPLTV FGPKGIRSFV
110 120 130 140 150
ETALAVSGTK LRYELNIVEI DEGVIFDDER FSVIAKRLDH GMPSYGFRVV
160 170 180 190 200
EKDLPGPLLV ERLQALGVRP GPIYQEIKQG KTVVLDDGTV IDGREFVGPP
210 220 230 240 250
QKGRIVAVLG DTRFCEAAIE LARDADVVVH EATFAAAEQR LAHDYFHSTT
260 270 280 290 300
TDAAEVARRA GAKRLILTHI SSRYQGEAAL QLVAEARSVF PNTELAVDFA

SFSIPRG
Length:307
Mass (Da):33,543
Last modified:February 1, 2005 - v1
Checksum:iFD908ACB3ECD82C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000043 Genomic DNA. Translation: BAD76618.1.
RefSeqiWP_011231815.1. NC_006510.1.

Genome annotation databases

EnsemblBacteriaiBAD76618; BAD76618; GK2333.
KEGGigka:GK2333.

Similar proteinsi

Entry informationi

Entry nameiRNZ_GEOKA
AccessioniPrimary (citable) accession number: Q5KXG8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: February 1, 2005
Last modified: October 25, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families