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Q5KX77 (GCSPA_GEOKA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene names
Name:gcvPA
Ordered Locus Names:GK2424
OrganismGeobacillus kaustophilus (strain HTA426) [Complete proteome] [HAMAP]
Taxonomic identifier235909 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus

Protein attributes

Sequence length448 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00712

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 448448Probable glycine dehydrogenase (decarboxylating) subunit 1 HAMAP-Rule MF_00712
PRO_1000045656

Sequences

Sequence LengthMass (Da)Tools
Q5KX77 [UniParc].

Last modified February 1, 2005. Version 1.
Checksum: 3D24D4C13A99B2FF

FASTA44849,099
        10         20         30         40         50         60 
MLHRYLPMTE EDKQEMLKTI GVASIDDLFA DIPEQVRFRG ELKVKPAKSE PELWKELAAL 

        70         80         90        100        110        120 
AEKNASVKQY VSFLGAGVYD HYIPAVVDHV LSRSEFYTAY TPYQPEISQG ELQAIFEFQT 

       130        140        150        160        170        180 
MVCELTGMDV ANSSMYDGGT ALAEAVLLSA AHTKRKKVLI STAVHPQYRE VVRTYAKGQK 

       190        200        210        220        230        240 
LEVKEIPYDG GITDLKALEA EMGDDVACVV VQYPNFFGQI EPLKAIAPLA HEKKSLFVVA 

       250        260        270        280        290        300 
SNPLALGVLT PPGAFGADIV VGDMQPFGIP TQFGGPHCGY FAVKAPLMRK IPGRLVGQTT 

       310        320        330        340        350        360 
DEDGRRGFVL TLQAREQHIR RDKATSNICS NQALNALAAS VALSALGKRG VKEMAAMNIQ 

       370        380        390        400        410        420 
KAHYAKVELE KRGLSSPFAG PFFNEFVIRL GRPVSDVNDR LLEKGIIGGY DLGADYPELA 

       430        440 
GHMLVAVTEL RTKEEIDRFV NELGDGHA 

« Hide

References

[1]"Thermoadaptation trait revealed by the genome sequence of thermophilic Geobacillus kaustophilus."
Takami H., Takaki Y., Chee G.-J., Nishi S., Shimamura S., Suzuki H., Matsui S., Uchiyama I.
Nucleic Acids Res. 32:6292-6303(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HTA426.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000043 Genomic DNA. Translation: BAD76709.1.
RefSeqYP_148277.1. NC_006510.1.

3D structure databases

ProteinModelPortalQ5KX77.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING235909.GK2424.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAD76709; BAD76709; GK2424.
GeneID3185761.
KEGGgka:GK2424.
PATRIC21966297. VBIGeoKau81518_2597.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0403.
HOGENOMHOG000132025.
KOK00282.
OMARLVGQTE.
OrthoDBEOG6XWV3B.

Enzyme and pathway databases

BioCycGKAU235909:GJO7-2519-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00712. GcvPA.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFPIRSF006815. GcvPA. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPA_GEOKA
AccessionPrimary (citable) accession number: Q5KX77
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 1, 2005
Last modified: May 14, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families