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Protein

Deoxyribose-phosphate aldolase

Gene

deoC

Organism
Geobacillus kaustophilus (strain HTA426)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.UniRule annotation

Catalytic activityi

2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.UniRule annotation

Pathwayi: 2-deoxy-D-ribose 1-phosphate degradation

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Deoxyribose-phosphate aldolase (deoC)
This subpathway is part of the pathway 2-deoxy-D-ribose 1-phosphate degradation, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate, the pathway 2-deoxy-D-ribose 1-phosphate degradation and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei91Proton donor/acceptorUniRule annotation1
Active sitei154Schiff-base intermediate with acetaldehydeUniRule annotation1
Active sitei183Proton donor/acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
LigandSchiff base

Enzyme and pathway databases

UniPathwayiUPA00002; UER00468

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyribose-phosphate aldolaseUniRule annotation (EC:4.1.2.4UniRule annotation)
Short name:
DERAUniRule annotation
Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolaseUniRule annotation
PhosphodeoxyriboaldolaseUniRule annotation
Short name:
DeoxyriboaldolaseUniRule annotation
Gene namesi
Name:deoCUniRule annotation
Ordered Locus Names:GK2499
OrganismiGeobacillus kaustophilus (strain HTA426)
Taxonomic identifieri235909 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillusGeobacillus thermoleovorans group
Proteomesi
  • UP000001172 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002315411 – 223Deoxyribose-phosphate aldolaseAdd BLAST223

Proteomic databases

PRIDEiQ5KX02

Interactioni

Protein-protein interaction databases

STRINGi235909.GK2499

Structurei

3D structure databases

ProteinModelPortaliQ5KX02
SMRiQ5KX02
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105FCI Bacteria
COG0274 LUCA
HOGENOMiHOG000241645
KOiK01619
OrthoDBiPOG091H00TV

Family and domain databases

CDDicd00959 DeoC, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00114 DeoC_type1, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR011343 DeoC
IPR002915 DeoC/FbaB/lacD_aldolase
IPR028581 DeoC_typeI
PANTHERiPTHR10889 PTHR10889, 1 hit
PTHR10889:SF1 PTHR10889:SF1, 1 hit
PfamiView protein in Pfam
PF01791 DeoC, 1 hit
PIRSFiPIRSF001357 DeoC, 1 hit
SMARTiView protein in SMART
SM01133 DeoC, 1 hit
TIGRFAMsiTIGR00126 deoC, 1 hit

Sequencei

Sequence statusi: Complete.

Q5KX02-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMNIAKMID HTLLKPEATE QQIVQLCTEA KQYGFASVCV NPTWVKTAAR
60 70 80 90 100
ELSGTDVRVC TVIGFPLGAT TPETKAFETT NAIENGAREV DMVINIGALK
110 120 130 140 150
SGQDELVERD IRAVVEAAAG RALVKVIVET ALLTDEEKVR ACQLAVKAGA
160 170 180 190 200
DYVKTSTGFS GGGATVEDVA LMRKTVGDRA GVKASGGVRD WKTAEAMINA
210 220
GATRIGTSSG VAIVTGGTGR ADY
Length:223
Mass (Da):23,353
Last modified:April 4, 2006 - v2
Checksum:i0E25F62A88D0AB78
GO

Sequence cautioni

The sequence BAD76784 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000043 Genomic DNA Translation: BAD76784.1 Different initiation.
RefSeqiWP_014196373.1, NC_006510.1

Genome annotation databases

EnsemblBacteriaiBAD76784; BAD76784; GK2499
KEGGigka:GK2499

Similar proteinsi

Entry informationi

Entry nameiDEOC_GEOKA
AccessioniPrimary (citable) accession number: Q5KX02
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: May 23, 2018
This is version 77 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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