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Protein

Chaperone protein DnaK

Gene

dnaK

Organism
Geobacillus kaustophilus (strain HTA426)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a chaperone.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciGKAU235909:GJO7-2599-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperone protein DnaKUniRule annotation
Alternative name(s):
HSP70UniRule annotation
Heat shock 70 kDa proteinUniRule annotation
Heat shock protein 70UniRule annotation
Gene namesi
Name:dnaKUniRule annotation
Ordered Locus Names:GK2504
OrganismiGeobacillus kaustophilus (strain HTA426)
Taxonomic identifieri235909 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
Proteomesi
  • UP000001172 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 607607Chaperone protein DnaKPRO_0000225966Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei172 – 1721Phosphothreonine; by autocatalysisUniRule annotation

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ5KWZ7.

Expressioni

Inductioni

By stress conditions e.g. heat shock.UniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi235909.GK2504.

Structurei

Secondary structure

1
607
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 96Combined sources
Beta strandi11 – 2010Combined sources
Beta strandi23 – 264Combined sources
Beta strandi34 – 374Combined sources
Beta strandi39 – 5012Combined sources
Helixi51 – 544Combined sources
Turni55 – 595Combined sources
Beta strandi61 – 655Combined sources
Helixi67 – 693Combined sources
Turni70 – 723Combined sources
Beta strandi77 – 793Combined sources
Beta strandi82 – 843Combined sources
Helixi86 – 10520Combined sources
Beta strandi111 – 1166Combined sources
Helixi122 – 13413Combined sources
Beta strandi138 – 1447Combined sources
Helixi145 – 1528Combined sources
Helixi155 – 1573Combined sources
Beta strandi160 – 1689Combined sources
Beta strandi173 – 1819Combined sources
Beta strandi184 – 19310Combined sources
Helixi198 – 21720Combined sources
Helixi221 – 2233Combined sources
Helixi225 – 24117Combined sources
Turni242 – 2443Combined sources
Beta strandi246 – 25813Combined sources
Beta strandi261 – 27010Combined sources
Helixi271 – 2777Combined sources
Helixi279 – 2835Combined sources
Helixi286 – 29611Combined sources
Helixi300 – 3023Combined sources
Beta strandi304 – 3107Combined sources
Helixi311 – 3144Combined sources
Helixi316 – 32611Combined sources
Turni336 – 3383Combined sources
Helixi339 – 35214Combined sources
Beta strandi365 – 3728Combined sources
Turni373 – 3753Combined sources
Beta strandi376 – 3816Combined sources
Beta strandi386 – 39510Combined sources
Beta strandi404 – 41613Combined sources
Helixi417 – 4193Combined sources
Beta strandi420 – 42910Combined sources
Beta strandi441 – 4477Combined sources
Beta strandi453 – 4597Combined sources
Turni460 – 4623Combined sources
Beta strandi465 – 4706Combined sources
Helixi479 – 49012Combined sources
Helixi493 – 5008Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2V7YX-ray2.37A1-509[»]
4ANIX-ray4.09C/D/G/H1-509[»]
ProteinModelPortaliQ5KWZ7.
SMRiQ5KWZ7. Positions 1-567.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5KWZ7.

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CFG. Bacteria.
COG0443. LUCA.
HOGENOMiHOG000228137.
KOiK04043.
OMAiEKMAPPQ.
OrthoDBiEOG6JMMSV.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5KWZ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKIIGIDLG TTNSCVAVLE GGEVKVIPNP EGNRTTPSVV AFKNGERLVG
60 70 80 90 100
EVAKRQAITN PNTIISIKRH MGTDYKVEIE GKQYTPQEIS AIILQYLKSY
110 120 130 140 150
AEDYLGEPVT RAVITVPAYF NDAQRQATKD AGRIAGLEVE RIINEPTAAA
160 170 180 190 200
LAYGLDKEED QTILVYDLGG GTFDVSILEL GDGVFEVKAT AGDNHLGGDD
210 220 230 240 250
FDQVIIDYLV NQFKQEHGID LSKDKMALQR LKDAAEKAKK ELSGVTQTQI
260 270 280 290 300
SLPFISANEN GPLHLEMTLT RAKFEELSAH LVERTMGPVR QALQDAGLTP
310 320 330 340 350
ADIDKVILVG GSTRIPAVQE AIKRELGKEP HKGVNPDEVV AIGAAIQGGV
360 370 380 390 400
IAGEVKDVVL LDVTPLSLGI ETMGGVFTKL IERNTTIPTS KSQVFTTAAD
410 420 430 440 450
NQTTVDIHVL QGERPMAADN KSLGRFQLTG IPPAPRGVPQ IEVTFDIDAN
460 470 480 490 500
GIVHVRAKDL GTNKEQSITI KSSSGLSEEE IQRMIKEAEE NAEADRKRKE
510 520 530 540 550
AAELRNEADQ LIFMTDKTLK EVEGKVSADE IKKAQDAKEA LKAALEKNDI
560 570 580 590 600
DDIRKKKDAL QEAVQQLSIK LYEQAAKQAQ SAGSQGGAAN HKDNVVDAEF

EEVNDDK
Length:607
Mass (Da):65,830
Last modified:February 1, 2005 - v1
Checksum:iD42D2168CEE358A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000043 Genomic DNA. Translation: BAD76789.1.
RefSeqiWP_011231983.1. NC_006510.1.

Genome annotation databases

EnsemblBacteriaiBAD76789; BAD76789; GK2504.
GeneIDi3183874.
KEGGigka:GK2504.
PATRICi21966465. VBIGeoKau81518_2681.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000043 Genomic DNA. Translation: BAD76789.1.
RefSeqiWP_011231983.1. NC_006510.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2V7YX-ray2.37A1-509[»]
4ANIX-ray4.09C/D/G/H1-509[»]
ProteinModelPortaliQ5KWZ7.
SMRiQ5KWZ7. Positions 1-567.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi235909.GK2504.

Proteomic databases

PRIDEiQ5KWZ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD76789; BAD76789; GK2504.
GeneIDi3183874.
KEGGigka:GK2504.
PATRICi21966465. VBIGeoKau81518_2681.

Phylogenomic databases

eggNOGiENOG4105CFG. Bacteria.
COG0443. LUCA.
HOGENOMiHOG000228137.
KOiK04043.
OMAiEKMAPPQ.
OrthoDBiEOG6JMMSV.

Enzyme and pathway databases

BioCyciGKAU235909:GJO7-2599-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ5KWZ7.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Thermoadaptation trait revealed by the genome sequence of thermophilic Geobacillus kaustophilus."
    Takami H., Takaki Y., Chee G.-J., Nishi S., Shimamura S., Suzuki H., Matsui S., Uchiyama I.
    Nucleic Acids Res. 32:6292-6303(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HTA426.

Entry informationi

Entry nameiDNAK_GEOKA
AccessioniPrimary (citable) accession number: Q5KWZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: February 1, 2005
Last modified: November 11, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.