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Protein

Chaperone protein DnaK

Gene

dnaK

Organism
Geobacillus kaustophilus (strain HTA426)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a chaperone.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperone protein DnaKUniRule annotation
Alternative name(s):
HSP70UniRule annotation
Heat shock 70 kDa proteinUniRule annotation
Heat shock protein 70UniRule annotation
Gene namesi
Name:dnaKUniRule annotation
Ordered Locus Names:GK2504
OrganismiGeobacillus kaustophilus (strain HTA426)
Taxonomic identifieri235909 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
Proteomesi
  • UP000001172 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002259661 – 607Chaperone protein DnaKAdd BLAST607

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei172Phosphothreonine; by autocatalysisUniRule annotation1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ5KWZ7.

Expressioni

Inductioni

By stress conditions e.g. heat shock.UniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi235909.GK2504.

Structurei

Secondary structure

1607
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 9Combined sources6
Beta strandi11 – 20Combined sources10
Beta strandi23 – 26Combined sources4
Beta strandi34 – 37Combined sources4
Beta strandi39 – 50Combined sources12
Helixi51 – 54Combined sources4
Turni55 – 59Combined sources5
Beta strandi61 – 65Combined sources5
Helixi67 – 69Combined sources3
Turni70 – 72Combined sources3
Beta strandi77 – 79Combined sources3
Beta strandi82 – 84Combined sources3
Helixi86 – 105Combined sources20
Beta strandi111 – 116Combined sources6
Helixi122 – 134Combined sources13
Beta strandi138 – 144Combined sources7
Helixi145 – 152Combined sources8
Helixi155 – 157Combined sources3
Beta strandi160 – 168Combined sources9
Beta strandi173 – 181Combined sources9
Beta strandi184 – 193Combined sources10
Helixi198 – 217Combined sources20
Helixi221 – 223Combined sources3
Helixi225 – 241Combined sources17
Turni242 – 244Combined sources3
Beta strandi246 – 258Combined sources13
Beta strandi261 – 270Combined sources10
Helixi271 – 277Combined sources7
Helixi279 – 283Combined sources5
Helixi286 – 296Combined sources11
Helixi300 – 302Combined sources3
Beta strandi304 – 310Combined sources7
Helixi311 – 314Combined sources4
Helixi316 – 326Combined sources11
Turni336 – 338Combined sources3
Helixi339 – 352Combined sources14
Beta strandi365 – 372Combined sources8
Turni373 – 375Combined sources3
Beta strandi376 – 381Combined sources6
Beta strandi386 – 395Combined sources10
Beta strandi404 – 416Combined sources13
Helixi417 – 419Combined sources3
Beta strandi420 – 429Combined sources10
Beta strandi441 – 447Combined sources7
Beta strandi453 – 459Combined sources7
Turni460 – 462Combined sources3
Beta strandi465 – 470Combined sources6
Helixi479 – 490Combined sources12
Helixi493 – 500Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2V7YX-ray2.37A1-509[»]
4ANIX-ray4.09C/D/G/H1-509[»]
ProteinModelPortaliQ5KWZ7.
SMRiQ5KWZ7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5KWZ7.

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CFG. Bacteria.
COG0443. LUCA.
HOGENOMiHOG000228137.
KOiK04043.
OMAiEKMAPPQ.
OrthoDBiPOG091H01UE.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK. 1 hit.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5KWZ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKIIGIDLG TTNSCVAVLE GGEVKVIPNP EGNRTTPSVV AFKNGERLVG
60 70 80 90 100
EVAKRQAITN PNTIISIKRH MGTDYKVEIE GKQYTPQEIS AIILQYLKSY
110 120 130 140 150
AEDYLGEPVT RAVITVPAYF NDAQRQATKD AGRIAGLEVE RIINEPTAAA
160 170 180 190 200
LAYGLDKEED QTILVYDLGG GTFDVSILEL GDGVFEVKAT AGDNHLGGDD
210 220 230 240 250
FDQVIIDYLV NQFKQEHGID LSKDKMALQR LKDAAEKAKK ELSGVTQTQI
260 270 280 290 300
SLPFISANEN GPLHLEMTLT RAKFEELSAH LVERTMGPVR QALQDAGLTP
310 320 330 340 350
ADIDKVILVG GSTRIPAVQE AIKRELGKEP HKGVNPDEVV AIGAAIQGGV
360 370 380 390 400
IAGEVKDVVL LDVTPLSLGI ETMGGVFTKL IERNTTIPTS KSQVFTTAAD
410 420 430 440 450
NQTTVDIHVL QGERPMAADN KSLGRFQLTG IPPAPRGVPQ IEVTFDIDAN
460 470 480 490 500
GIVHVRAKDL GTNKEQSITI KSSSGLSEEE IQRMIKEAEE NAEADRKRKE
510 520 530 540 550
AAELRNEADQ LIFMTDKTLK EVEGKVSADE IKKAQDAKEA LKAALEKNDI
560 570 580 590 600
DDIRKKKDAL QEAVQQLSIK LYEQAAKQAQ SAGSQGGAAN HKDNVVDAEF

EEVNDDK
Length:607
Mass (Da):65,830
Last modified:February 1, 2005 - v1
Checksum:iD42D2168CEE358A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000043 Genomic DNA. Translation: BAD76789.1.
RefSeqiWP_011231983.1. NC_006510.1.

Genome annotation databases

EnsemblBacteriaiBAD76789; BAD76789; GK2504.
GeneIDi3183874.
KEGGigka:GK2504.
PATRICi21966465. VBIGeoKau81518_2681.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000043 Genomic DNA. Translation: BAD76789.1.
RefSeqiWP_011231983.1. NC_006510.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2V7YX-ray2.37A1-509[»]
4ANIX-ray4.09C/D/G/H1-509[»]
ProteinModelPortaliQ5KWZ7.
SMRiQ5KWZ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi235909.GK2504.

Proteomic databases

PRIDEiQ5KWZ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD76789; BAD76789; GK2504.
GeneIDi3183874.
KEGGigka:GK2504.
PATRICi21966465. VBIGeoKau81518_2681.

Phylogenomic databases

eggNOGiENOG4105CFG. Bacteria.
COG0443. LUCA.
HOGENOMiHOG000228137.
KOiK04043.
OMAiEKMAPPQ.
OrthoDBiPOG091H01UE.

Miscellaneous databases

EvolutionaryTraceiQ5KWZ7.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK. 1 hit.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDNAK_GEOKA
AccessioniPrimary (citable) accession number: Q5KWZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: February 1, 2005
Last modified: November 2, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.