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Protein

DNA polymerase

Gene

polA

Organism
Geobacillus kaustophilus (strain HTA426)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei617CTPCombined sources1
Binding sitei631CTPCombined sources1
Metal bindingi655MagnesiumCombined sources1
Metal bindingi655ManganeseCombined sources1
Metal bindingi656Magnesium; via carbonyl oxygenCombined sources1
Metal bindingi656Manganese; via carbonyl oxygenCombined sources1
Binding sitei658CTPCombined sources1
Binding sitei684CTPCombined sources1
Binding sitei704CTPCombined sources1
Binding sitei708CTPCombined sources1
Binding sitei712CTPCombined sources1
Binding sitei716CTPCombined sources1
Metal bindingi832MagnesiumCombined sources1
Metal bindingi832ManganeseCombined sources1
Binding sitei832CTPCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi471 – 475CTPCombined sources5
Nucleotide bindingi769 – 770CTPCombined sources2

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymeraseImported, Hydrolase, NucleaseSAAS annotation, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA replicationUniRule annotation

Keywords - Ligandi

DNA-bindingUniRule annotation, MagnesiumCombined sources, ManganeseCombined sources, Metal-bindingCombined sources, Nucleotide-bindingCombined sources

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymeraseUniRule annotation (EC:2.7.7.7UniRule annotation)
Gene namesi
Name:polAImported
Ordered Locus Names:GK2730Imported
OrganismiGeobacillus kaustophilus (strain HTA426)Imported
Taxonomic identifieri235909 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
Proteomesi
  • UP000001172 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi235909.GK2730.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NJWX-ray1.90A299-878[»]
1UA0X-ray2.10A299-878[»]
2HHUX-ray1.80A300-878[»]
2HHVX-ray1.55A300-878[»]
2HHWX-ray1.88A/D299-878[»]
2HHXX-ray2.26A300-878[»]
2HVIX-ray1.98A/D300-878[»]
3HP6X-ray1.81A/D299-878[»]
3PV8X-ray1.52A/D287-878[»]
3PX0X-ray1.73A/D287-878[»]
3PX4X-ray1.58A/D287-878[»]
3PX6X-ray1.59A/D287-878[»]
4DQIX-ray1.69A/D287-878[»]
4DQPX-ray1.74A/D287-878[»]
4DQQX-ray1.59A/D287-878[»]
4DQRX-ray1.95A/D287-878[»]
4DQSX-ray1.66A287-878[»]
4DS4X-ray1.68A/D287-878[»]
4DS5X-ray1.68A/D287-878[»]
4DSEX-ray1.67A/D287-878[»]
4DSFX-ray1.66A/D287-878[»]
4E0DX-ray1.58A287-878[»]
4EZ6X-ray1.64A/D287-878[»]
4EZ9X-ray1.64A/D287-878[»]
4F2RX-ray1.63A/D287-878[»]
4F2SX-ray1.65A/D287-878[»]
4F3OX-ray1.57A/D287-878[»]
4F4KX-ray1.60A/D287-878[»]
4F8RX-ray1.64A/D287-878[»]
ProteinModelPortaliQ5KWC1.
SMRiQ5KWC1.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5KWC1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 26453EXOcInterPro annotationAdd BLAST260
Domaini302 – 4683'-5' exonucleaseInterPro annotationAdd BLAST167
Domaini635 – 842POLAcInterPro annotationAdd BLAST208

Sequence similaritiesi

Belongs to the DNA polymerase type-A family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C2M. Bacteria.
COG0258. LUCA.
COG0749. LUCA.
HOGENOMiHOG000020998.
KOiK02335.
OMAiCFDTETT.
OrthoDBiPOG091H00PR.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
3.40.50.1010. 1 hit.
InterProiIPR002562. 3'-5'_exonuclease_dom.
IPR020046. 5-3_exonucl_a-hlix_arch_N.
IPR020045. 5-3_exonuclease_C.
IPR002421. 5-3_exonuclease_N.
IPR019760. DNA-dir_DNA_pol_A_CS.
IPR001098. DNA-dir_DNA_pol_A_palm_dom.
IPR018320. DNA_polymerase_1.
IPR002298. DNA_polymerase_A.
IPR008918. HhH2.
IPR029060. PIN_domain-like.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF01367. 5_3_exonuc. 1 hit.
PF02739. 5_3_exonuc_N. 1 hit.
PF00476. DNA_pol_A. 1 hit.
[Graphical view]
PRINTSiPR00868. DNAPOLI.
SMARTiSM00474. 35EXOc. 1 hit.
SM00475. 53EXOc. 1 hit.
SM00279. HhH2. 1 hit.
SM00482. POLAc. 1 hit.
[Graphical view]
SUPFAMiSSF47807. SSF47807. 1 hit.
SSF53098. SSF53098. 1 hit.
SSF88723. SSF88723. 1 hit.
TIGRFAMsiTIGR00593. pola. 1 hit.
PROSITEiPS00447. DNA_POLYMERASE_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5KWC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLKKKLVLI DGSSVAYRAF FALPLLHNDK GIHTNAVYGF TMMLNKILAE
60 70 80 90 100
EEPTHMLVAF DAGKTTFRHE AFQEYKGGRQ QTPPELSEQF PLLRELLRAY
110 120 130 140 150
RIPAYELENY EADDIIGTLA ARAEQEGFEV KVISGDRDLT QLASPHVTVD
160 170 180 190 200
ITKKGITDIE PYTPETVREK YGLTPEQIVD LKGLMGDKSD NIPGVPGIGE
210 220 230 240 250
KTAVKLLRQF GTVENVLASI DEIKGEKLKE TLRQHREMAL LSKKLAAIRR
260 270 280 290 300
DAPVELSLDD IVYQGEDREK VVALFKELGF QSFLEKMESP SSEEEKPLAK
310 320 330 340 350
MAFTLADRVT EEMLADKAAL VVEVVEENYH DAPIVGIAVV NEHGRFFLRP
360 370 380 390 400
ETALADPQFV AWLGDETKKK SMFDSKRAAV ALKWKGIELC GVSFDLLLAA
410 420 430 440 450
YLLDPAQGVD DVAAAAKMKQ YEAVRPDEAV YGKGAKRAVP DEPVLAEHLV
460 470 480 490 500
RKAAAIWELE RPFLDELRRN EQDRLLVELE QPLSSILAEM EFAGVKVDTK
510 520 530 540 550
RLEQMGKELA EQLGTVEQRI YELAGQEFNI NSPKQLGVIL FEKLQLPVLK
560 570 580 590 600
KTKTGYSTSA DVLEKLAPYH EIVENILHYR QLGKLQSTYI EGLLKVVRPD
610 620 630 640 650
TKKVHTIFNQ ALTQTGRLSS TEPNLQNIPI RLEEGRKIRQ AFVPSESDWL
660 670 680 690 700
IFAADYSQIE LRVLAHIAED DNLMEAFRRD LDIHTKTAMD IFQVSEDEVT
710 720 730 740 750
PNMRRQAKAV NFGIVYGISD YGLAQNLNIS RKEAAEFIER YFESFPGVKR
760 770 780 790 800
YMENIVQEAK QKGYVTTLLH RRRYLPDITS RNFNVRSFAE RMAMNTPIQG
810 820 830 840 850
SAADIIKKAM IDLNARLKEE RLQARLLLQV HDELILEAPK EEMERLCRLV
860 870
PEVMEQAVTL RVPLKVDYHY GSTWYDAK
Length:878
Mass (Da):99,646
Last modified:February 1, 2005 - v1
Checksum:iD50E58940CE21B01
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000043 Genomic DNA. Translation: BAD77015.1.
RefSeqiWP_011232204.1. NC_006510.1.

Genome annotation databases

EnsemblBacteriaiBAD77015; BAD77015; GK2730.
GeneIDi3184068.
KEGGigka:GK2730.
PATRICi21966931. VBIGeoKau81518_2914.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000043 Genomic DNA. Translation: BAD77015.1.
RefSeqiWP_011232204.1. NC_006510.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NJWX-ray1.90A299-878[»]
1UA0X-ray2.10A299-878[»]
2HHUX-ray1.80A300-878[»]
2HHVX-ray1.55A300-878[»]
2HHWX-ray1.88A/D299-878[»]
2HHXX-ray2.26A300-878[»]
2HVIX-ray1.98A/D300-878[»]
3HP6X-ray1.81A/D299-878[»]
3PV8X-ray1.52A/D287-878[»]
3PX0X-ray1.73A/D287-878[»]
3PX4X-ray1.58A/D287-878[»]
3PX6X-ray1.59A/D287-878[»]
4DQIX-ray1.69A/D287-878[»]
4DQPX-ray1.74A/D287-878[»]
4DQQX-ray1.59A/D287-878[»]
4DQRX-ray1.95A/D287-878[»]
4DQSX-ray1.66A287-878[»]
4DS4X-ray1.68A/D287-878[»]
4DS5X-ray1.68A/D287-878[»]
4DSEX-ray1.67A/D287-878[»]
4DSFX-ray1.66A/D287-878[»]
4E0DX-ray1.58A287-878[»]
4EZ6X-ray1.64A/D287-878[»]
4EZ9X-ray1.64A/D287-878[»]
4F2RX-ray1.63A/D287-878[»]
4F2SX-ray1.65A/D287-878[»]
4F3OX-ray1.57A/D287-878[»]
4F4KX-ray1.60A/D287-878[»]
4F8RX-ray1.64A/D287-878[»]
ProteinModelPortaliQ5KWC1.
SMRiQ5KWC1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi235909.GK2730.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD77015; BAD77015; GK2730.
GeneIDi3184068.
KEGGigka:GK2730.
PATRICi21966931. VBIGeoKau81518_2914.

Phylogenomic databases

eggNOGiENOG4105C2M. Bacteria.
COG0258. LUCA.
COG0749. LUCA.
HOGENOMiHOG000020998.
KOiK02335.
OMAiCFDTETT.
OrthoDBiPOG091H00PR.

Miscellaneous databases

EvolutionaryTraceiQ5KWC1.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
3.40.50.1010. 1 hit.
InterProiIPR002562. 3'-5'_exonuclease_dom.
IPR020046. 5-3_exonucl_a-hlix_arch_N.
IPR020045. 5-3_exonuclease_C.
IPR002421. 5-3_exonuclease_N.
IPR019760. DNA-dir_DNA_pol_A_CS.
IPR001098. DNA-dir_DNA_pol_A_palm_dom.
IPR018320. DNA_polymerase_1.
IPR002298. DNA_polymerase_A.
IPR008918. HhH2.
IPR029060. PIN_domain-like.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF01367. 5_3_exonuc. 1 hit.
PF02739. 5_3_exonuc_N. 1 hit.
PF00476. DNA_pol_A. 1 hit.
[Graphical view]
PRINTSiPR00868. DNAPOLI.
SMARTiSM00474. 35EXOc. 1 hit.
SM00475. 53EXOc. 1 hit.
SM00279. HhH2. 1 hit.
SM00482. POLAc. 1 hit.
[Graphical view]
SUPFAMiSSF47807. SSF47807. 1 hit.
SSF53098. SSF53098. 1 hit.
SSF88723. SSF88723. 1 hit.
TIGRFAMsiTIGR00593. pola. 1 hit.
PROSITEiPS00447. DNA_POLYMERASE_A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ5KWC1_GEOKA
AccessioniPrimary (citable) accession number: Q5KWC1
Entry historyi
Integrated into UniProtKB/TrEMBL: February 1, 2005
Last sequence update: February 1, 2005
Last modified: November 30, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.