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Q5KW99 (Q5KW99_GEOKA) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Alanine dehydrogenase PIRNR PIRNR000183
EC=1.4.1.1 PIRNR PIRNR000183
Gene names
Ordered Locus Names:GK2752
OrganismGeobacillus kaustophilus (strain HTA426) [Complete proteome] [HAMAP]
Taxonomic identifier235909 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Geobacillus

Protein attributes

Sequence length372 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-alanine + H2O + NAD+ = pyruvate + NH3 + NADH. PIRNR PIRNR000183

Pathway

Amino-acid degradation; L-alanine degradation via dehydrogenase pathway; NH(3) and pyruvate from L-alanine: step 1/1. PIRNR PIRNR000183

Sequence similarities

Belongs to the AlaDH/PNT family. PIRNR PIRNR000183

Ontologies

Keywords
   LigandNAD PIRNR PIRNR000183
   Molecular functionOxidoreductase PIRNR PIRNR000183 EMBL BAD77037.1
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functionalanine dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q5KW99 [UniParc].

Last modified February 1, 2005. Version 1.
Checksum: BDFE6AC2A2CCB931

FASTA37239,369
        10         20         30         40         50         60 
MKIGIPKEIK NNENRVAITP AGVMTLVKAG HDVYVETEAG AGSGFSDSEY EKAGAVIVTK 

        70         80         90        100        110        120 
AEDAWAAEMV LKVKEPLAEE FRYFRPGLIL FTYLHLAAAE ALTKALVEQK VVGIAYETVQ 

       130        140        150        160        170        180 
LANGSLPLLT PMSEVAGRMS VQVGAQFLEK PHGGKGILLG GVPGVRRGKV TIIGGGTAGT 

       190        200        210        220        230        240 
NAAKIAVGLG ADVTILDINA ERLRELDDLF GDQVTTLMSN SYHIAECVRE SDLVVGAVLI 

       250        260        270        280        290        300 
PGAKAPKLVT EEMVRSMTPG SVLVDVAIDQ GGIFETTDRV TTHDDPTYVK HGVVHYAVAN 

       310        320        330        340        350        360 
MPGAVPRTST FALTNVTIPY ALQIANKGYR AACLDNPALL KGINTLDGHI VYEAVAAAHN 

       370 
MPYTDVHSLL QG

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References

[1]"Thermoadaptation trait revealed by the genome sequence of thermophilic Geobacillus kaustophilus."
Takami H., Takaki Y., Chee G.-J., Nishi S., Shimamura S., Suzuki H., Matsui S., Uchiyama I.
Nucleic Acids Res. 32:6292-6303(2004) [PubMed: 15576355] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HTA426.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000043 Genomic DNA. Translation: BAD77037.1.
RefSeqYP_148605.1. NC_006510.1.

3D structure databases

ProteinModelPortalQ5KW99.
SMRQ5KW99. Positions 1-372.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3185051.
GenomeReviewsGene locus GK2752 in contig BA000043_GR.
KEGGgka:GK2752.
NMPDRfig|235909.3.peg.2938.
PATRIC21966975. VBIGeoKau81518_2936.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG289735.
OMAQKVVGIA.
ProtClustDBCLSK2459131.

Family and domain databases

InterProIPR008142. Ala_DH/PNT_CS1.
IPR008143. Ala_DH/PNT_CS2.
IPR008141. Ala_DH/Pyr_transHydgase.
IPR007886. AlaDH/PNT_N.
IPR007698. AlaDH/PNT_NAD(H)-bd.
[Graphical view]
KOK00259.
PANTHERPTHR10160:SF3. PTHR10160:SF3. 1 hit.
PfamPF01262. AlaDh_PNT_C. 1 hit.
PF05222. AlaDh_PNT_N. 1 hit.
[Graphical view]
PIRSFPIRSF000183. Alanine_dh. 1 hit.
SMARTSM01002. AlaDh_PNT_C. 1 hit.
SM01003. AlaDh_PNT_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR00518. AlaDH. 1 hit.
PROSITEPS00836. ALADH_PNT_1. 1 hit.
PS00837. ALADH_PNT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ5KW99_GEOKA
AccessionPrimary (citable) accession number: Q5KW99
Entry history
Integrated into UniProtKB/TrEMBL: February 1, 2005
Last sequence update: February 1, 2005
Last modified: January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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