Q5KW59 (PPNK2_GEOKA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable inorganic polyphosphate/ATP-NAD kinase 2
Short name=Poly(P)/ATP NAD kinase 2
EC=2.7.1.23

Gene names

Name:	ppnK2
Ordered Locus Names:	GK2792

Organism

Geobacillus kaustophilus (strain HTA426) [Complete proteome] [HAMAP]

Taxonomic identifier

235909 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Geobacillus

Protein attributes

Sequence length	267 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus By similarity. HAMAP MF_00361
Catalytic activity	ATP + NAD+ = ADP + NADP+. HAMAP MF_00361
Cofactor	Divalent metal ions By similarity. HAMAP MF_00361
Subcellular location	Cytoplasm By similarity HAMAP MF_00361.
Sequence similarities	Belongs to the NAD kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding NAD NADP Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW NAD+ kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 267	267	Probable inorganic polyphosphate/ATP-NAD kinase 2 HAMAP MF_00361		PRO_0000229638

Sequences

	Sequence		Length	Mass (Da)
	Q5KW59 [UniParc]. Last modified February 1, 2005. Version 1. Checksum: 87FB161D79FEEB2F	FASTA	267	30,489
	10 20 30 40 50 60 MDMERNRLYF FYKRDDKLIE RVKPLIELAE RGPFVVVDDY REANIIVSIG DDGAFLQAVR 70 80 90 100 110 120 QTGFLPDRLY VGVSVLPARG FYCDFHIDDI DHMVEAAKNW KLEVRRYPII EVTIDGAASF 130 140 150 160 170 180 FCLNECSIRS QIIKTMAIDV FIDDLHFETF RGDGIIVSTP TGSTGYNKSV HGAVVDPLLP 190 200 210 220 230 240 CFQVSELASL NSNRYRTLGS PFILSGSRTL TLKMSEETSH FPIIGLDNEA LSIQHIERID 250 260 IRLSDRVVKT VRLKDNSFWD KVKRVFL

References

[1]

"Thermoadaptation trait revealed by the genome sequence of thermophilic Geobacillus kaustophilus." Takami H., Takaki Y., Chee G.-J., Nishi S., Shimamura S., Suzuki H., Matsui S., Uchiyama I. Nucleic Acids Res. 32:6292-6303(2004) [PubMed: 15576355] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HTA426.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000043 Genomic DNA. Translation: BAD77077.1.
RefSeq	YP_148645.1. NC_006510.1.
3D structure databases
ProteinModelPortal	Q5KW59.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3186439.
GenomeReviews	Gene locus GK2792 in contig BA000043_GR.
KEGG	gka:GK2792.
NMPDR	fig|235909.3.peg.3056.
PATRIC	21967061. VBIGeoKau81518_2979.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG314020.
OMA	DDLHFET.
ProtClustDB	PRK03501.
Enzyme and pathway databases
BioCyc	GKAU235909:GK2792-MONOMER.
Family and domain databases
HAMAP	MF_00361. NAD_kinase. [Tree]
InterPro	IPR016064. ATP-NAD_kinase_PpnK-typ. IPR017438. ATP-NAD_kinase_PpnK-typ_a/b. IPR017437. ATP-NAD_kinase_PpnK-typ_all-b. IPR002504. polyP/ATP_NADK_prd. [Graphical view]
Gene3D	G3DSA:2.60.200.30. ATP-NAD_kinase_PpnK-typ. 1 hit. G3DSA:3.40.50.10330. ATP-NAD_kinase_PpnK-typ_a/b. 1 hit.
KO	K00858.
PANTHER	PTHR20275. ATP_NADK. 1 hit.
Pfam	PF01513. NAD_kinase. 1 hit. [Graphical view]
SUPFAM	SSF111331. ATP-NAD_kinase_PpnK-typ. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PPNK2_GEOKA

Accession

Primary (citable) accession number: Q5KW59

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	February 1, 2005
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program