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Protein

Tyrosine--tRNA ligase

Gene

tyrS

Organism
Geobacillus kaustophilus (strain HTA426)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).UniRule annotation

Catalytic activityi

ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei34TyrosineUniRule annotation1
Binding sitei169TyrosineUniRule annotation1
Binding sitei173TyrosineUniRule annotation1
Binding sitei233ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase, RNA-binding
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine--tRNA ligaseUniRule annotation (EC:6.1.1.1UniRule annotation)
Alternative name(s):
Tyrosyl-tRNA synthetaseUniRule annotation
Short name:
TyrRSUniRule annotation
Gene namesi
Name:tyrSUniRule annotation
Ordered Locus Names:GK2803
OrganismiGeobacillus kaustophilus (strain HTA426)
Taxonomic identifieri235909 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillusGeobacillus thermoleovorans group
Proteomesi
  • UP000001172 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002347131 – 419Tyrosine--tRNA ligaseAdd BLAST419

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi235909.GK2803

Structurei

3D structure databases

ProteinModelPortaliQ5KW48
SMRiQ5KW48
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini352 – 419S4 RNA-bindingUniRule annotationAdd BLAST68

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi39 – 48"HIGH" region10
Motifi230 – 234"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DA0 Bacteria
COG0162 LUCA
HOGENOMiHOG000242790
KOiK01866
OMAiVNYMMAK
OrthoDBiPOG091H00WT

Family and domain databases

CDDicd00165 S4, 1 hit
Gene3Di3.10.290.10, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_02006 Tyr_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002942 S4_RNA-bd
IPR036986 S4_RNA-bd_sf
IPR002307 Tyr-tRNA-ligase
IPR024088 Tyr-tRNA-ligase_bac-type
IPR024107 Tyr-tRNA-ligase_bac_1
PANTHERiPTHR11766 PTHR11766, 1 hit
PfamiView protein in Pfam
PF01479 S4, 1 hit
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01040 TRNASYNTHTYR
SMARTiView protein in SMART
SM00363 S4, 1 hit
TIGRFAMsiTIGR00234 tyrS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit
PS50889 S4, 1 hit

Sequencei

Sequence statusi: Complete.

Q5KW48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLLAELQWR GLVNQTTDED GLRKLLNEER VTLYCGFDPT ADSLHIGNLA
60 70 80 90 100
AILTLRRFQQ AGHRPIALVG GATGLIGDPS GKKSERTLNA KETVEAWSAR
110 120 130 140 150
IKEQLGRFLD FEADGNPAKI KNNYDWIGPL DVITFLRDVG KHFSVNYMMA
160 170 180 190 200
KESVQSRIET GISFTEFSYM MLQAYDFLRL YETEGCRLQI GGSDQWGNIT
210 220 230 240 250
AGLELIRKTK GEARAFGLTI PLVTKADGTK FGKTESGTIW LDKEKTSPYE
260 270 280 290 300
FYQFWINTDD RDVIRYLKYF TFLSKEEIEA LEQELREAPE KRAAQKALAE
310 320 330 340 350
EVTKLVHGEE ALRQAIRISE ALFSGDIANL TAAEIEQGFK DVPSFVHEGG
360 370 380 390 400
DVPLVELLVS AGISPSKRQA REDIQSGAIY VNGERLQDVG AILTAEHRLE
410
GRFTVIRRGK KKYYLIRYA
Length:419
Mass (Da):47,175
Last modified:February 1, 2005 - v1
Checksum:i13785CDF71D60E42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000043 Genomic DNA Translation: BAD77088.1
RefSeqiWP_011232277.1, NC_006510.1

Genome annotation databases

EnsemblBacteriaiBAD77088; BAD77088; GK2803
KEGGigka:GK2803
PATRICifig|235909.7.peg.2989

Similar proteinsi

Entry informationi

Entry nameiSYY_GEOKA
AccessioniPrimary (citable) accession number: Q5KW48
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: February 1, 2005
Last modified: March 28, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health