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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Geobacillus kaustophilus (strain HTA426)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei579ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:GK2842
OrganismiGeobacillus kaustophilus (strain HTA426)
Taxonomic identifieri235909 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillusGeobacillus thermoleovorans group
Proteomesi
  • UP000001172 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001520191 – 805Leucine--tRNA ligaseAdd BLAST805

Proteomic databases

PRIDEiQ5KW09

Interactioni

Protein-protein interaction databases

STRINGi235909.GK2842

Structurei

3D structure databases

ProteinModelPortaliQ5KW09
SMRiQ5KW09
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi40 – 51"HIGH" regionAdd BLAST12
Motifi576 – 580"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200748
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q5KW09-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFNHREIEQ KWQDYWEKNK TFRTPDDDDK PKFYVLDMFP YPSGAGLHVG
60 70 80 90 100
HPEGYTATDI LARMKRMQGY NVLHPMGWDA FGLPAEQYAL DTGNDPAEFT
110 120 130 140 150
QKNIDNFRRQ IKSLGFSYDW DREINTTDPN YYKWTQWIFL KLYEKGLAYM
160 170 180 190 200
DEVPVNWCPA LGTVLANEEV INGRSERGGH PVIRKPMRQW MLKITAYADR
210 220 230 240 250
LLEDLEELDW PESIKEMQRN WIGRSEGAEI EFAVHGHDET FTVFTTRPDT
260 270 280 290 300
LFGATYTVLA PEHPLVEKIT TPEQKPAVDA YLKEIQSKSD LERTDLAKEK
310 320 330 340 350
TGVFTGAYAI HPVTGDRLPI WIADYVLMSY GTGAIMAVPA HDERDYEFAK
360 370 380 390 400
KFHLPMKEVV AGGDIEKEPY TGDGEHINSE FLNGLNKQEA IDKMIAWLEE
410 420 430 440 450
HGKGRKKVSY RLRDWLFSRQ RYWGEPIPII HWEDGTMTPV PEEELPLVLP
460 470 480 490 500
KTDEIRPSGT GESPLANIEE WVNVVDPKTG KKGRRETNTM PQWAGSCWYY
510 520 530 540 550
LRYIDPHNDK QLADPEKLKK WLPVDVYIGG AEHAVLHLLY ARFWHKFLYD
560 570 580 590 600
LGIVPTKEPF QKLFNQGMIL GENNEKMSKS KGNVVNPDDI IESHGADTLR
610 620 630 640 650
LYEMFMGPLE ASIAWSTKGL DGARRFLDRV WRLFVTENGE LNPNIVDEPA
660 670 680 690 700
NDTLERIYHQ TVKKVTEDYE SLRFNTAISQ LMVFINEAYK AEQMKKEYME
710 720 730 740 750
GFVKLLSPVC PHIGEELWQK LGHTDTIAYE PWPTYDETKL VEDVVEIVVQ
760 770 780 790 800
INGKVRSRLH VPVDLPKEAL EERALADEKI KEQLEGKTVR KVIAVPGKLV

NIVAN
Length:805
Mass (Da):92,875
Last modified:February 1, 2005 - v1
Checksum:iC5D51D58D9C78270
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000043 Genomic DNA Translation: BAD77127.1
RefSeqiWP_011232314.1, NC_006510.1

Genome annotation databases

EnsemblBacteriaiBAD77127; BAD77127; GK2842
KEGGigka:GK2842

Similar proteinsi

Entry informationi

Entry nameiSYL_GEOKA
AccessioniPrimary (citable) accession number: Q5KW09
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: February 1, 2005
Last modified: May 23, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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