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Q5KW09

- SYL_GEOKA

UniProt

Q5KW09 - SYL_GEOKA

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Protein
Leucine--tRNA ligase
Gene
leuS, GK2842
Organism
Geobacillus kaustophilus (strain HTA426)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei579 – 5791ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciGKAU235909:GJO7-2937-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:GK2842
OrganismiGeobacillus kaustophilus (strain HTA426)
Taxonomic identifieri235909 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
ProteomesiUP000001172: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 805805Leucine--tRNA ligaseUniRule annotation
PRO_0000152019Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi235909.GK2842.

Structurei

3D structure databases

ProteinModelPortaliQ5KW09.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionUniRule annotation
Add
BLAST
Motifi576 – 5805"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5KW09-1 [UniParc]FASTAAdd to Basket

« Hide

MSFNHREIEQ KWQDYWEKNK TFRTPDDDDK PKFYVLDMFP YPSGAGLHVG    50
HPEGYTATDI LARMKRMQGY NVLHPMGWDA FGLPAEQYAL DTGNDPAEFT 100
QKNIDNFRRQ IKSLGFSYDW DREINTTDPN YYKWTQWIFL KLYEKGLAYM 150
DEVPVNWCPA LGTVLANEEV INGRSERGGH PVIRKPMRQW MLKITAYADR 200
LLEDLEELDW PESIKEMQRN WIGRSEGAEI EFAVHGHDET FTVFTTRPDT 250
LFGATYTVLA PEHPLVEKIT TPEQKPAVDA YLKEIQSKSD LERTDLAKEK 300
TGVFTGAYAI HPVTGDRLPI WIADYVLMSY GTGAIMAVPA HDERDYEFAK 350
KFHLPMKEVV AGGDIEKEPY TGDGEHINSE FLNGLNKQEA IDKMIAWLEE 400
HGKGRKKVSY RLRDWLFSRQ RYWGEPIPII HWEDGTMTPV PEEELPLVLP 450
KTDEIRPSGT GESPLANIEE WVNVVDPKTG KKGRRETNTM PQWAGSCWYY 500
LRYIDPHNDK QLADPEKLKK WLPVDVYIGG AEHAVLHLLY ARFWHKFLYD 550
LGIVPTKEPF QKLFNQGMIL GENNEKMSKS KGNVVNPDDI IESHGADTLR 600
LYEMFMGPLE ASIAWSTKGL DGARRFLDRV WRLFVTENGE LNPNIVDEPA 650
NDTLERIYHQ TVKKVTEDYE SLRFNTAISQ LMVFINEAYK AEQMKKEYME 700
GFVKLLSPVC PHIGEELWQK LGHTDTIAYE PWPTYDETKL VEDVVEIVVQ 750
INGKVRSRLH VPVDLPKEAL EERALADEKI KEQLEGKTVR KVIAVPGKLV 800
NIVAN 805
Length:805
Mass (Da):92,875
Last modified:February 1, 2005 - v1
Checksum:iC5D51D58D9C78270
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000043 Genomic DNA. Translation: BAD77127.1.
RefSeqiYP_148695.1. NC_006510.1.

Genome annotation databases

EnsemblBacteriaiBAD77127; BAD77127; GK2842.
GeneIDi3185286.
KEGGigka:GK2842.
PATRICi21967171. VBIGeoKau81518_3034.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000043 Genomic DNA. Translation: BAD77127.1 .
RefSeqi YP_148695.1. NC_006510.1.

3D structure databases

ProteinModelPortali Q5KW09.
ModBasei Search...

Protein-protein interaction databases

STRINGi 235909.GK2842.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD77127 ; BAD77127 ; GK2842 .
GeneIDi 3185286.
KEGGi gka:GK2842.
PATRICi 21967171. VBIGeoKau81518_3034.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci GKAU235909:GJO7-2937-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Thermoadaptation trait revealed by the genome sequence of thermophilic Geobacillus kaustophilus."
    Takami H., Takaki Y., Chee G.-J., Nishi S., Shimamura S., Suzuki H., Matsui S., Uchiyama I.
    Nucleic Acids Res. 32:6292-6303(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HTA426.

Entry informationi

Entry nameiSYL_GEOKA
AccessioniPrimary (citable) accession number: Q5KW09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: February 1, 2005
Last modified: June 11, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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