Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q5KVS7 (G6PI_GEOKA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi
Ordered Locus Names:GK2924
OrganismGeobacillus kaustophilus (strain HTA426) [Complete proteome] [HAMAP]
Taxonomic identifier235909 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Geobacillus

Protein attributes

Sequence length449 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473

Subcellular location

Cytoplasm By similarity HAMAP MF_00473.

Sequence similarities

Belongs to the GPI family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   PTMPhosphoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

glycolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 449449Glucose-6-phosphate isomerase HAMAP MF_00473
PRO_0000180646

Sites

Active site2901Proton donor By similarity
Active site3111 By similarity
Active site4251 By similarity

Amino acid modifications

Modified residue381Phosphothreonine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5KVS7 [UniParc].

Last modified February 1, 2005. Version 1.
Checksum: 64D34EFB96DF91F6

FASTA44950,572
        10         20         30         40         50         60 
MTHIRFDYSK ALAFFGEHEL TYLRDAVKVA HHSLHEKTGV GSDFLGWLDW PVDYDKEEFA 

        70         80         90        100        110        120 
RIKEAAKKIQ SDSDVLVVIG IGGSYLGARA AIEMLHHSFY NALPKEKRKT PQIIFVGNNI 

       130        140        150        160        170        180 
SSTYMKDVID FLEGKDFSIN VISKSGTTTE PAIAFRIFRK LLEEKYGKEE ARRRIYATTD 

       190        200        210        220        230        240 
SKRGALRTLA NEEGYETFVI PDDIGGRYSV LTAVGLLPIA ASGADINAMM EGAAKARDDF 

       250        260        270        280        290        300 
SSSELEENAA YQYAAIRNIL YNKGKTIELL VNYEPALHYF AEWWKQLFGE SEGKDQKGIY 

       310        320        330        340        350        360 
PASADFSTDL HSLGQYIQEG RRDLFETVLK LEEPRHELII EAEENDLDGL NYLAGKTVDF 

       370        380        390        400        410        420 
VNTKAFEGTL LAHTDGGVPN LVITLPKLDE YTFGYLVYFF EKACAMSGYL LGVNPFDQPG 

       430        440 
VEAYKKNMFA LLGKPGYEQL KEELEKRLK

« Hide

References

[1]"Thermoadaptation trait revealed by the genome sequence of thermophilic Geobacillus kaustophilus."
Takami H., Takaki Y., Chee G.-J., Nishi S., Shimamura S., Suzuki H., Matsui S., Uchiyama I.
Nucleic Acids Res. 32:6292-6303(2004) [PubMed: 15576355] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HTA426.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000043 Genomic DNA. Translation: BAD77209.1.
RefSeqYP_148777.1. NC_006510.1.

3D structure databases

ProteinModelPortalQ5KVS7.
SMRQ5KVS7. Positions 4-448.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3184086.
GenomeReviewsGene locus GK2924 in contig BA000043_GR.
KEGGgka:GK2924.
NMPDRfig|235909.3.peg.2546.
PATRIC21967375. VBIGeoKau81518_3119.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG615843.
OMADNLDGLN.
ProtClustDBPRK14097.

Enzyme and pathway databases

BioCycGKAU235909:GK2924-MONOMER.

Family and domain databases

HAMAPMF_00473. G6P_isomerase.
[Tree]
InterProIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
KOK01810.
PANTHERPTHR11469. G6P_Isomerase. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_GEOKA
AccessionPrimary (citable) accession number: Q5KVS7
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: February 1, 2005
Last modified: January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents