true2008-01-152024-03-2795DAPF_GEOKAThermoadaptation trait revealed by the genome sequence of thermophilic Geobacillus kaustophilus.Takami H.Takaki Y.Chee G.-J.Nishi S.Shimamura S.Suzuki H.Matsui S.Uchiyama I.doi:10.1093/nar/gkh9702004Nucleic Acids Res.326292-6303NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]HTA426BacteriaDAP_epimeraseDAP_epimerase_ASDAP_epimerase_DapFDapFDIAMINOPIMELATE EPIMERASEDIAMINOPIMELATE EPIMERASE, CHLOROPLASTICDAP_epimeraseDiaminopimelate epimerase-likeDAP_EPIMERASEDiaminopimelate epimeraseDAP epimerase5.1.1.7PLP-independent amino acid racemasedapFGK2957Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.Homodimer.Belongs to the diaminopimelate epimerase family.Diaminopimelate epimerase311931290Proton donor76Proton acceptor22614677778166199217218227228Could be important to modulate the pK values of the two catalytic cysteine residues168Could be important to modulate the pK values of the two catalytic cysteine residuessubstrate2005-02-01131193ed66a9e0c9d84500c62d827d10508217MRSFSFTKMHGLGNSYIYVDLFRETLPEEELPAIARSVADVHTGIGSDGLILICPSEKAPVKMRIFNSDGSEGKNCGNGLRCVAKYAYEHGIVSDRTFLIETLSGLVEARVAVADGEVTSVTVDMGEPRLERSAIPMLGPEAERVVAEPFAIAGGEYEITAVSMGNPHVIFYVDDIQKAPVTTLGPLVEKDPRFPEGVNVEFVEVVNERELHFRVWERGSGVTQACGTGACAAVVASVLNGKTARGEETVVHLAGGDLTIVWGHDGRVRMTGPAETVCTGVYYYRGGRNGtrue