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Q5KVC6

- HISX_GEOKA

UniProt

Q5KVC6 - HISX_GEOKA

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Geobacillus kaustophilus (strain HTA426)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (01 Feb 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei121 – 1211NADUniRule annotation
    Binding sitei183 – 1831NADUniRule annotation
    Binding sitei206 – 2061NADUniRule annotation
    Binding sitei229 – 2291SubstrateUniRule annotation
    Metal bindingi251 – 2511ZincUniRule annotation
    Binding sitei251 – 2511SubstrateUniRule annotation
    Metal bindingi254 – 2541ZincUniRule annotation
    Binding sitei254 – 2541SubstrateUniRule annotation
    Active sitei319 – 3191Proton acceptorUniRule annotation
    Active sitei320 – 3201Proton acceptorUniRule annotation
    Binding sitei320 – 3201SubstrateUniRule annotation
    Metal bindingi353 – 3531ZincUniRule annotation
    Binding sitei353 – 3531SubstrateUniRule annotation
    Binding sitei407 – 4071SubstrateUniRule annotation
    Metal bindingi412 – 4121ZincUniRule annotation
    Binding sitei412 – 4121SubstrateUniRule annotation

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyciGKAU235909:GJO7-3188-MONOMER.
    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
    Short name:
    HDHUniRule annotation
    Gene namesi
    Name:hisDUniRule annotation
    Ordered Locus Names:GK3075
    OrganismiGeobacillus kaustophilus (strain HTA426)
    Taxonomic identifieri235909 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
    ProteomesiUP000001172: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 424424Histidinol dehydrogenasePRO_0000135773Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi235909.GK3075.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5KVC6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiYAAKLCG.
    OrthoDBiEOG6CVVCR.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5KVC6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKIERIRGGV SLRRTIESGT EEQRRAVLDI IANVRDRGDA ALKEYTERFD    50
    GVKLDSLKVT EEEMKRAHAA MDAEMLEIIR QAAANIRDYH KRQKRESWWM 100
    TKEDGTILGQ KVTPLDAVGL YVPGGTAAYP SSVLMNVIPA QVAGVKRIVI 150
    TSPPNKDGTL PAGVLAAAYE LGVTEIYKVG GAQAIAALAY GTETIRPVDK 200
    IFGPGNIYVA LAKREVFGHV AIDMIAGPSE IVVLADETAR PDEIAADLLS 250
    QAEHDVRASA ILVTPSMKLA LAVASEVERQ LETLPRRDIA QAALENYGAI 300
    YVTETLEEAV DVVNELAPEH LEVMTAEPLA LFGRLRHAGA MFFGRFSSEP 350
    VGDYFAGPNH VLPTNGTARF SSGLSVDEFV KKSSVIVYSE TALKQHGDKI 400
    AAFARLEGLE AHARAIEVRL EKGE 424
    Length:424
    Mass (Da):46,055
    Last modified:February 1, 2005 - v1
    Checksum:iDDD2807E49EB959D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000043 Genomic DNA. Translation: BAD77360.1.
    RefSeqiYP_148928.1. NC_006510.1.

    Genome annotation databases

    EnsemblBacteriaiBAD77360; BAD77360; GK3075.
    GeneIDi3184204.
    KEGGigka:GK3075.
    PATRICi21967704. VBIGeoKau81518_3282.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000043 Genomic DNA. Translation: BAD77360.1 .
    RefSeqi YP_148928.1. NC_006510.1.

    3D structure databases

    ProteinModelPortali Q5KVC6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 235909.GK3075.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD77360 ; BAD77360 ; GK3075 .
    GeneIDi 3184204.
    KEGGi gka:GK3075.
    PATRICi 21967704. VBIGeoKau81518_3282.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi YAAKLCG.
    OrthoDBi EOG6CVVCR.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .
    BioCyci GKAU235909:GJO7-3188-MONOMER.

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Thermoadaptation trait revealed by the genome sequence of thermophilic Geobacillus kaustophilus."
      Takami H., Takaki Y., Chee G.-J., Nishi S., Shimamura S., Suzuki H., Matsui S., Uchiyama I.
      Nucleic Acids Res. 32:6292-6303(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HTA426.

    Entry informationi

    Entry nameiHISX_GEOKA
    AccessioniPrimary (citable) accession number: Q5KVC6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3