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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Geobacillus kaustophilus (strain HTA426)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 9 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase regulatory subunit (hisZ), ATP phosphoribosyltransferase (hisG)
  2. Histidine biosynthesis bifunctional protein HisIE (hisI)
  3. Histidine biosynthesis bifunctional protein HisIE (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisH (hisH), Imidazole glycerol phosphate synthase subunit HisF (hisF)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei121NADUniRule annotation1
Binding sitei183NADUniRule annotation1
Binding sitei206NADUniRule annotation1
Binding sitei229SubstrateUniRule annotation1
Metal bindingi251ZincUniRule annotation1
Binding sitei251SubstrateUniRule annotation1
Metal bindingi254ZincUniRule annotation1
Binding sitei254SubstrateUniRule annotation1
Active sitei319Proton acceptorUniRule annotation1
Active sitei320Proton acceptorUniRule annotation1
Binding sitei320SubstrateUniRule annotation1
Metal bindingi353ZincUniRule annotation1
Binding sitei353SubstrateUniRule annotation1
Binding sitei407SubstrateUniRule annotation1
Metal bindingi412ZincUniRule annotation1
Binding sitei412SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAmino-acid biosynthesis, Histidine biosynthesis
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:GK3075
OrganismiGeobacillus kaustophilus (strain HTA426)
Taxonomic identifieri235909 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillusGeobacillus thermoleovorans group
Proteomesi
  • UP000001172 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001357731 – 424Histidinol dehydrogenaseAdd BLAST424

Proteomic databases

PRIDEiQ5KVC6

Interactioni

Protein-protein interaction databases

STRINGi235909.GK3075

Structurei

3D structure databases

ProteinModelPortaliQ5KVC6
SMRiQ5KVC6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CEK Bacteria
COG0141 LUCA
HOGENOMiHOG000243914
KOiK00013
OMAiQAEHDPM
OrthoDBiPOG091H03YX

Family and domain databases

CDDicd06572 Histidinol_dh, 1 hit
HAMAPiMF_01024 HisD, 1 hit
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR001692 Histidinol_DH_CS
IPR022695 Histidinol_DH_monofunct
IPR012131 Hstdl_DH
PANTHERiPTHR21256 PTHR21256, 1 hit
PfamiView protein in Pfam
PF00815 Histidinol_dh, 1 hit
PIRSFiPIRSF000099 Histidinol_dh, 1 hit
PRINTSiPR00083 HOLDHDRGNASE
SUPFAMiSSF53720 SSF53720, 1 hit
TIGRFAMsiTIGR00069 hisD, 1 hit
PROSITEiView protein in PROSITE
PS00611 HISOL_DEHYDROGENASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q5KVC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIERIRGGV SLRRTIESGT EEQRRAVLDI IANVRDRGDA ALKEYTERFD
60 70 80 90 100
GVKLDSLKVT EEEMKRAHAA MDAEMLEIIR QAAANIRDYH KRQKRESWWM
110 120 130 140 150
TKEDGTILGQ KVTPLDAVGL YVPGGTAAYP SSVLMNVIPA QVAGVKRIVI
160 170 180 190 200
TSPPNKDGTL PAGVLAAAYE LGVTEIYKVG GAQAIAALAY GTETIRPVDK
210 220 230 240 250
IFGPGNIYVA LAKREVFGHV AIDMIAGPSE IVVLADETAR PDEIAADLLS
260 270 280 290 300
QAEHDVRASA ILVTPSMKLA LAVASEVERQ LETLPRRDIA QAALENYGAI
310 320 330 340 350
YVTETLEEAV DVVNELAPEH LEVMTAEPLA LFGRLRHAGA MFFGRFSSEP
360 370 380 390 400
VGDYFAGPNH VLPTNGTARF SSGLSVDEFV KKSSVIVYSE TALKQHGDKI
410 420
AAFARLEGLE AHARAIEVRL EKGE
Length:424
Mass (Da):46,055
Last modified:February 1, 2005 - v1
Checksum:iDDD2807E49EB959D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000043 Genomic DNA Translation: BAD77360.1
RefSeqiWP_011232545.1, NC_006510.1

Genome annotation databases

EnsemblBacteriaiBAD77360; BAD77360; GK3075
KEGGigka:GK3075

Similar proteinsi

Entry informationi

Entry nameiHISX_GEOKA
AccessioniPrimary (citable) accession number: Q5KVC6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: February 1, 2005
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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