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Q5KVC6

- HISX_GEOKA

UniProt

Q5KVC6 - HISX_GEOKA

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Protein
Histidinol dehydrogenase
Gene
hisD, GK3075
Organism
Geobacillus kaustophilus (strain HTA426)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei121 – 1211NAD By similarity
Binding sitei183 – 1831NAD By similarity
Binding sitei206 – 2061NAD By similarity
Binding sitei229 – 2291Substrate By similarity
Metal bindingi251 – 2511Zinc By similarity
Binding sitei251 – 2511Substrate By similarity
Metal bindingi254 – 2541Zinc By similarity
Binding sitei254 – 2541Substrate By similarity
Active sitei319 – 3191Proton acceptor By similarity
Active sitei320 – 3201Proton acceptor By similarity
Binding sitei320 – 3201Substrate By similarity
Metal bindingi353 – 3531Zinc By similarity
Binding sitei353 – 3531Substrate By similarity
Binding sitei407 – 4071Substrate By similarity
Metal bindingi412 – 4121Zinc By similarity
Binding sitei412 – 4121Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciGKAU235909:GJO7-3188-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:GK3075
OrganismiGeobacillus kaustophilus (strain HTA426)
Taxonomic identifieri235909 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
ProteomesiUP000001172: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 424424Histidinol dehydrogenaseUniRule annotation
PRO_0000135773Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi235909.GK3075.

Structurei

3D structure databases

ProteinModelPortaliQ5KVC6.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5KVC6-1 [UniParc]FASTAAdd to Basket

« Hide

MKIERIRGGV SLRRTIESGT EEQRRAVLDI IANVRDRGDA ALKEYTERFD    50
GVKLDSLKVT EEEMKRAHAA MDAEMLEIIR QAAANIRDYH KRQKRESWWM 100
TKEDGTILGQ KVTPLDAVGL YVPGGTAAYP SSVLMNVIPA QVAGVKRIVI 150
TSPPNKDGTL PAGVLAAAYE LGVTEIYKVG GAQAIAALAY GTETIRPVDK 200
IFGPGNIYVA LAKREVFGHV AIDMIAGPSE IVVLADETAR PDEIAADLLS 250
QAEHDVRASA ILVTPSMKLA LAVASEVERQ LETLPRRDIA QAALENYGAI 300
YVTETLEEAV DVVNELAPEH LEVMTAEPLA LFGRLRHAGA MFFGRFSSEP 350
VGDYFAGPNH VLPTNGTARF SSGLSVDEFV KKSSVIVYSE TALKQHGDKI 400
AAFARLEGLE AHARAIEVRL EKGE 424
Length:424
Mass (Da):46,055
Last modified:February 1, 2005 - v1
Checksum:iDDD2807E49EB959D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000043 Genomic DNA. Translation: BAD77360.1.
RefSeqiYP_148928.1. NC_006510.1.

Genome annotation databases

EnsemblBacteriaiBAD77360; BAD77360; GK3075.
GeneIDi3184204.
KEGGigka:GK3075.
PATRICi21967704. VBIGeoKau81518_3282.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000043 Genomic DNA. Translation: BAD77360.1 .
RefSeqi YP_148928.1. NC_006510.1.

3D structure databases

ProteinModelPortali Q5KVC6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 235909.GK3075.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD77360 ; BAD77360 ; GK3075 .
GeneIDi 3184204.
KEGGi gka:GK3075.
PATRICi 21967704. VBIGeoKau81518_3282.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci GKAU235909:GJO7-3188-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Thermoadaptation trait revealed by the genome sequence of thermophilic Geobacillus kaustophilus."
    Takami H., Takaki Y., Chee G.-J., Nishi S., Shimamura S., Suzuki H., Matsui S., Uchiyama I.
    Nucleic Acids Res. 32:6292-6303(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HTA426.

Entry informationi

Entry nameiHISX_GEOKA
AccessioniPrimary (citable) accession number: Q5KVC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: February 1, 2005
Last modified: May 14, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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